The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives
Fuente:
Wiley Open Access
Salvato in:
| Autori principali: | , , , , , , , |
|---|---|
| Natura: | Artículo Open Access |
| Pubblicazione: |
Wiley
2024
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1867013712043311104 |
|---|---|
| author | Xirui He Xufei Chen Yan Yang Jingyi Gu Yulu Xie Yujie Liu Man Hao Michael Heinrich |
| author_facet | Xirui He Xufei Chen Yan Yang Jingyi Gu Yulu Xie Yujie Liu Man Hao Michael Heinrich Xirui He Xufei Chen Yan Yang Jingyi Gu Yulu Xie Yujie Liu Man Hao Michael Heinrich |
| collection | Wiley Open Access |
| contents | The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives Xirui He Xufei Chen Yan Yang Jingyi Gu Yulu Xie Yujie Liu Man Hao Michael Heinrich Phytotherapy Research AbstractCentral nervous system (CNS)‐related diseases have a high mortality rate, are a serious threat to physical and mental health, and have always been an important area of research. Gastrodin, the main active metabolite of Gastrodia elata Blume, used in Chinese medicine and food, has a wide range of pharmacological effects, mostly related to CNS disorders. This review aims to systematically summarize and discuss the effects and underlying mechanisms of gastrodin in the treatment of CNS diseases, and to assess its potential for further development as a lead drug in both biomedicine and traditional Chinese medicine. Studies on the pharmacological effects of gastrodin on the CNS indicate that it may exert anti‐neurodegenerative, cerebrovascular protective, and ameliorative effects on diabetic encephalopathy, perioperative neurocognitive dysfunction, epilepsy, Tourette's syndrome, depression and anxiety, and sleep disorders through various mechanisms. To date, 110 gastrodin products have been approved for clinical use, but further multicenter clinical case–control studies are relatively scarce. Preclinical studies have confirmed that gastrodin can be used to treat CNS‐related disorders. However, important concerns need to be addressed in the context of likely non‐specific, assay interfering effects when gastrodin is studied using in vitro and in silico approaches, calling for a systematic assessment of the evidence to date. High‐quality clinical trials should have priority to evaluate the therapeutic safety and clinical efficacy of gastrodin. Further experimental research using appropriate in vivo models is also needed, focusing on neurodegenerative diseases, cerebral ischemic and hypoxic diseases, brain damage caused by methamphetamine or heavy metals, and epilepsy. 10.1002/ptr.8314 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1002/ptr.8314 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_ptr_8314 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives Xirui He Xufei Chen Yan Yang Jingyi Gu Yulu Xie Yujie Liu Man Hao Michael Heinrich Phytotherapy Research The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives Xirui He Xufei Chen Yan Yang Jingyi Gu Yulu Xie Yujie Liu Man Hao Michael Heinrich Phytotherapy Research AbstractCentral nervous system (CNS)‐related diseases have a high mortality rate, are a serious threat to physical and mental health, and have always been an important area of research. Gastrodin, the main active metabolite of Gastrodia elata Blume, used in Chinese medicine and food, has a wide range of pharmacological effects, mostly related to CNS disorders. This review aims to systematically summarize and discuss the effects and underlying mechanisms of gastrodin in the treatment of CNS diseases, and to assess its potential for further development as a lead drug in both biomedicine and traditional Chinese medicine. Studies on the pharmacological effects of gastrodin on the CNS indicate that it may exert anti‐neurodegenerative, cerebrovascular protective, and ameliorative effects on diabetic encephalopathy, perioperative neurocognitive dysfunction, epilepsy, Tourette's syndrome, depression and anxiety, and sleep disorders through various mechanisms. To date, 110 gastrodin products have been approved for clinical use, but further multicenter clinical case–control studies are relatively scarce. Preclinical studies have confirmed that gastrodin can be used to treat CNS‐related disorders. However, important concerns need to be addressed in the context of likely non‐specific, assay interfering effects when gastrodin is studied using in vitro and in silico approaches, calling for a systematic assessment of the evidence to date. High‐quality clinical trials should have priority to evaluate the therapeutic safety and clinical efficacy of gastrodin. Further experimental research using appropriate in vivo models is also needed, focusing on neurodegenerative diseases, cerebral ischemic and hypoxic diseases, brain damage caused by methamphetamine or heavy metals, and epilepsy. 10.1002/ptr.8314 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives |
| topic | Phytotherapy Research |
| url | https://onlinelibrary.wiley.com/doi/10.1002/ptr.8314 |