Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2025
|
| Sujets: | |
| Accès en ligne: | https://onlinelibrary.wiley.com/doi/10.1002/ptr.8490 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Table des matières:
- Plant‐Derived Natural Products for Dietary Intervention in Overweight and Obese Individuals: A Systematic Review and Network Meta‐Analysis Elvan Wiyarta Refael Alfa Budiman Devina Ravelia Tiffany Subroto Moon Nyeo Park Nelly Mayulu Nurpudji Astuti Taslim Raymond Rubianto Tjandrawinata Trina Ekawati Tallei Hardinsyah Hardinsyah Fahrul Nurkolis Bonglee Kim Phytotherapy Research ABSTRACTGrowing rates of overweight and obesity worldwide call for novel approaches to treatment, and plant‐derived natural products present a promising therapeutic option. Evaluate the efficacy of plant‐derived natural products as dietary interventions for overweight and obesity through a systematic review and network meta‐analysis. We conduct a systematic review and network meta‐analysis following PRISMA (Preferred Reporting Items for Systematic reviews and Meta‐Analyses) guidelines. We searched from five databases and registries up to March 2024, selecting randomized controlled trials examining dietary interventions with plant‐derived natural products for adults with obesity or overweight. The frequentist approach was used for the network meta‐analysis, assessing 13 metabolic and obesity‐related outcomes. Our review included 39 studies with 2513 participants with PROSPERO registration ID CRD42024520305. African Mango emerged as the most effective intervention, reducing body weight (MD: −10.00 kg, 95% CI: −16.74 to −3.26), waist circumference (MD: −11.70 cm, 95% CI: −17.15 to −6.25), total cholesterol (MD: −44.01 mg/dL, 95% CI: −58.95 to −29.08), triglycerides (MD: −42.65 mg/dL, 95% CI: −79.70 to −5.60), and random blood glucose (MD: −14.95 mg/dL, 95% CI: −18.60 to −11.30). Green coffee led to the largest reduction in body fat percentage (MD: −2.90%, 95% CI: −4.88 to −0.92) and BMI (MD: −3.08 kg/m2, 95% CI: −6.35 to 0.19). Ephedra was most effective in reducing fasting blood glucose (MD: −4.60 mg/dL, 95% CI: −5.49 to −3.71) and HOMA‐IR (MD: −16.20, 95% CI: −18.66 to −13.74). There were too few direct comparisons between various metabolites; thus, most of the comparisons were indirect comparisons through placebo. Plant‐derived natural products significantly impact obesity management, notably in body weight, waist circumference, and lipid profile reduction; however, further high‐quality and rigorous studies were needed to establish the clinical efficacy of the plant‐derived natural products. 10.1002/ptr.8490 http://onlinelibrary.wiley.com/termsAndConditions#vor