Optimisation of Heated Electrospray Ionisation Parameters to Minimise In‐Source Generated Impurities in the Analysis of Oligonucleotide Therapeutics
Fuente:
Wiley Open Access
Saved in:
| Main Authors: | Mollie A. Glenister, Ulrik Mistarz, Ken Cook, James L. Stephenson, Mark J. Dickman |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
Microcolumn Liquid Chromatography—Atmospheric Pressure Chemical Ionisation Tandem Mass Spectrometric Determination of Nitrosamine Impurities From Pharmaceutical Products
by: Sanjay K. Shendage, et al.
Published: (2026)
by: Sanjay K. Shendage, et al.
Published: (2026)
Analysis of Oligonucleotide Stability and Fragmentation: Impact of 2′‐Modifications, Base Composition, and Charge‐States
by: Christopher Gawlig, et al.
Published: (2026)
by: Christopher Gawlig, et al.
Published: (2026)
Professor Jean‐Francois Muller (1940–2024) Mass Spectrometry and Laser Desorption/Ionisation
by: Lionel Vernex‐Loset, et al.
Published: (2025)
by: Lionel Vernex‐Loset, et al.
Published: (2025)
Direct Probe Ionisation Mass Spectrometry for Rapid and Accurate Determination of Perfluoroalkyl and Polyfluoroalkyl Substance Concentrations
by: Tim P. Sidnell, et al.
Published: (2025)
by: Tim P. Sidnell, et al.
Published: (2025)
Wavelength Dependence of fs Laser Ablation Ionisation Mass Spectrometry: a Dedicated Study on NIST SRM 664
by: Valentine Grimaudo, et al.
Published: (2025)
by: Valentine Grimaudo, et al.
Published: (2025)
Establishment of a Mass Spectrometric Fingerprint of the Most Common Phytocannabinoids in Electrospray Ionization in Positive Ion Mode
by: Radwa Mahmoud, et al.
Published: (2024)
by: Radwa Mahmoud, et al.
Published: (2024)
Impurity Profiling and Mechanistic Investigation of the Photochemical Degradation of Tetrandrine
by: Jinmei Tan, et al.
Published: (2025)
by: Jinmei Tan, et al.
Published: (2025)
Alkali Halides as Matrices for the Detection of Saccharides and PEG600 by Electrospray Droplet Impact/Secondary Ion Mass Spectrometry (EDI/SIMS)
by: Rio Takaishi, et al.
Published: (2025)
by: Rio Takaishi, et al.
Published: (2025)
Identification and Characterization of Impurities in Fipronil Insecticide by LC–MS/MS and NMR
by: Sandhya Bobbali, et al.
Published: (2025)
by: Sandhya Bobbali, et al.
Published: (2025)
Rapid Determination of Isotopic Purity of Stable Isotope (D, 15 N, or 13 C)‐Labeled Organic Compounds by Electrospray Ionization‐High‐Resolution Mass Spectrometry
by: Chenlong Liang, et al.
Published: (2025)
by: Chenlong Liang, et al.
Published: (2025)
A Sustainable UHPLC‐PDA/QTOF‐MS Approach for Comprehensive Profiling of Amoxicillin Degradation Impurities
by: Vo Thi Kim Khuyen, et al.
Published: (2026)
by: Vo Thi Kim Khuyen, et al.
Published: (2026)
Identification and Quantification of Structurally Related Peptide Impurity in Linaclotide by Liquid Chromatography–High Resolution Mass Spectrometry
by: Jinlan Cheng, et al.
Published: (2026)
by: Jinlan Cheng, et al.
Published: (2026)
Unveiling Impurity Profiling of Synthetic Pathways of Organophosphorus Chlorpyrifos Through LC‐HRMS Metabolomics‐Based Approaches
by: C. Orlandi, et al.
Published: (2025)
by: C. Orlandi, et al.
Published: (2025)
Assessment of Nitrosamine Impurities in Lurasidone Hydrochloride Using APCI‐LC–MS/MS in MRM Mode for Regulatory Compliance and Stability Evaluation
by: Anant D. Yadav, et al.
Published: (2025)
by: Anant D. Yadav, et al.
Published: (2025)
Identification and Characterisation of UV Inactive Acid Degradation Impurities of Rebaudioside A Using LC‐HRMS/MS, Greenness Evaluation and In Silico Toxicity Studies
by: Muhammad Naheel, et al.
Published: (2025)
by: Muhammad Naheel, et al.
Published: (2025)
δ 13 C and δ 15 N Values of Residues Provide Insights Into Identification of the Explosive Source
by: James R. Ehleringer, et al.
Published: (2026)
by: James R. Ehleringer, et al.
Published: (2026)
Molecular Structure and Mass Spectral Data Quality–Driven Processing of High‐Resolution Mass Spectrometry for Quantitative Analysis
by: Fabien Fontaine, et al.
Published: (2025)
by: Fabien Fontaine, et al.
Published: (2025)
Critical Considerations for TOF‐SIMS Sample Preparation and Parameter Optimization
by: Chuqi Shi, et al.
Published: (2025)
by: Chuqi Shi, et al.
Published: (2025)
Online Study on the Smoke Aerosol of the Heat‐Not‐Burn Cigarette by Photoionization Mass Spectrometry
by: Chenjie Lei, et al.
Published: (2026)
by: Chenjie Lei, et al.
Published: (2026)
Cupressus torulosa , a Source of Antioxidant Polyphenols: An Analytical and Pharmacological Study
by: Radhika Khanna, et al.
Published: (2024)
by: Radhika Khanna, et al.
Published: (2024)
UHPLC–MS/MS Quantification of Human Cytosolic Aldehyde Oxidase: Heat‐Assisted In‐Solution Protein Denaturation and Digestion
by: Shiyan Chen, et al.
Published: (2026)
by: Shiyan Chen, et al.
Published: (2026)
Open‐Source System Suitability: Mass Spectrometry Query Language Lab (MassQLab)
by: Heather L. Winter, et al.
Published: (2025)
by: Heather L. Winter, et al.
Published: (2025)
Exploring the Bioactive Constituents and Therapeutic Mechanisms of Sanhuang Xiexin Decoction in Hypercholesterolemia Treatment Using UHPLC‐Q‐Orbitrap‐MS/MS Integrated With Metabolomics and Network Pharmacology
by: Yatong Zhu, et al.
Published: (2025)
by: Yatong Zhu, et al.
Published: (2025)
Critical Method Parameters to Evaluate When Developing a Method Using a Laser Diode Thermal Desorption (LDTD) Coupled to a Mass Spectrometer
by: Jonathan Rochon, et al.
Published: (2025)
by: Jonathan Rochon, et al.
Published: (2025)
Combining the 15 N Gas Flux Method and N 2 O Isotopocule Data for the Determination of Soil Microbial N 2 O Sources
by: Gianni Micucci, et al.
Published: (2024)
by: Gianni Micucci, et al.
Published: (2024)
Surface Ionization of Carbaryl, Papaverine, Cocaine, Morphine, and Triethylamine by Heated Surface‐Oxidized Metal Filaments of W, Re, Pd, Mo, Ti, and SUS304 Under Atmospheric Pressure: Ionization Mechanism
by: Kenzo Hiraoka, et al.
Published: (2025)
by: Kenzo Hiraoka, et al.
Published: (2025)
Fully resolved high‐precision measurement of 36 S for sulfur reference materials
by: Jiayang Sun, et al.
Published: (2024)
by: Jiayang Sun, et al.
Published: (2024)
Methylclostebol Metabolism Discovery by Untargeted Analysis
by: G. Barone, et al.
Published: (2025)
by: G. Barone, et al.
Published: (2025)
MALDI versus DESI mass spectrometry imaging of lipids in atherosclerotic plaque
by: Nuria Slijkhuis, et al.
Published: (2024)
by: Nuria Slijkhuis, et al.
Published: (2024)
Lithium Isotopic Analysis of Spodumene by Secondary Ion Mass Spectrometry
by: Ryan Sharpe, et al.
Published: (2026)
by: Ryan Sharpe, et al.
Published: (2026)
Trace detection of styphnate from pre‐ and post‐blast samples by hydrophilic interaction chromatography with tandem mass spectrometry
by: Sarah N. Sipe, et al.
Published: (2024)
by: Sarah N. Sipe, et al.
Published: (2024)
Determination of Collisional Cross Section Using Microscale High‐Field Asymmetric Waveform ion Mobility Spectroscopy–Mass Spectrometry (FAIMS‐MS)
by: Kristina Krasnova, et al.
Published: (2025)
by: Kristina Krasnova, et al.
Published: (2025)
Performance of Cryogenic Adsorbents for Use in Methane Bulk and Clumped Isotope Analysis
by: Nico Kueter, et al.
Published: (2025)
by: Nico Kueter, et al.
Published: (2025)
Comparison of CID and UVPD Activation to Achieve the Structural Characterization of Some Pyrolysis Bio‐Oil Components
by: Anthony Abou Dib, et al.
Published: (2025)
by: Anthony Abou Dib, et al.
Published: (2025)
Molecular Organ Lysate Imprinting: For Precision Recognition and Analysis of Organ‐Derived Proteins
by: Jatinderpal K. Sandhu, et al.
Published: (2025)
by: Jatinderpal K. Sandhu, et al.
Published: (2025)
Decoding Sickle Cell Disorders Using Flow Injection Analysis Mass Spectrometry
by: Deepalakshmi D. Putchen, et al.
Published: (2026)
by: Deepalakshmi D. Putchen, et al.
Published: (2026)
High Spatial Resolution (< 10 μm) Zircon SIMS Zr Isotope Analysis
by: Sheng He, et al.
Published: (2025)
by: Sheng He, et al.
Published: (2025)
Correction to “Performance of Cryogenic Adsorbents for Use in Methane Bulk and Clumped Isotope Analysis”
Published: (2025)
Published: (2025)
Fluorination of Silver Phosphate in Nickel Reaction Vessels for Triple Oxygen Isotope Analysis
by: Jordan A. G. Wostbrock, et al.
Published: (2026)
by: Jordan A. G. Wostbrock, et al.
Published: (2026)
Gas Chromatography–Mass Spectrometry Analysis and Bioactive Potential of Selected Medicinal Plants
by: Waheed Khan, et al.
Published: (2025)
by: Waheed Khan, et al.
Published: (2025)
Similar Items
-
Microcolumn Liquid Chromatography—Atmospheric Pressure Chemical Ionisation Tandem Mass Spectrometric Determination of Nitrosamine Impurities From Pharmaceutical Products
by: Sanjay K. Shendage, et al.
Published: (2026) -
Analysis of Oligonucleotide Stability and Fragmentation: Impact of 2′‐Modifications, Base Composition, and Charge‐States
by: Christopher Gawlig, et al.
Published: (2026) -
Professor Jean‐Francois Muller (1940–2024) Mass Spectrometry and Laser Desorption/Ionisation
by: Lionel Vernex‐Loset, et al.
Published: (2025) -
Direct Probe Ionisation Mass Spectrometry for Rapid and Accurate Determination of Perfluoroalkyl and Polyfluoroalkyl Substance Concentrations
by: Tim P. Sidnell, et al.
Published: (2025) -
Wavelength Dependence of fs Laser Ablation Ionisation Mass Spectrometry: a Dedicated Study on NIST SRM 664
by: Valentine Grimaudo, et al.
Published: (2025)