| _version_ | 1867021688121589760 |
|---|---|
| author | Thomas Burnett Franz König Thomas Jaki |
| author_facet | Thomas Burnett Franz König Thomas Jaki Thomas Burnett Franz König Thomas Jaki |
| collection | Wiley Open Access |
| contents | Adding experimental treatment arms to multi‐arm multi‐stage platform trials in progress Thomas Burnett Franz König Thomas Jaki Statistics in Medicine Multi‐arm multi‐stage (MAMS) platform trials efficiently compare several treatments with a common control arm. Crucially MAMS designs allow for adjustment for multiplicity if required. If for example, the active treatment arms in a clinical trial relate to different dose levels or different routes of administration of a drug, the strict control of the family‐wise error rate (FWER) is paramount. Suppose a further treatment becomes available, it is desirable to add this to the trial already in progress; to access both the practical and statistical benefits of the MAMS design. In any setting where control of the error rate is required, we must add corresponding hypotheses without compromising the validity of the testing procedure.To strongly control the FWER, MAMS designs use pre‐planned decision rules that determine the recruitment of the next stage of the trial based on the available data. The addition of a treatment arm presents an unplanned change to the design that we must account for in the testing procedure. We demonstrate the use of the conditional error approach to add hypotheses to any testing procedure that strongly controls the FWER. We use this framework to add treatments to a MAMS trial in progress. Simulations illustrate the possible characteristics of such procedures. 10.1002/sim.10090 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1002/sim.10090 |
| format | Artículo Open Access |
| id | wiley_oa_10_1002_sim_10090 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Adding experimental treatment arms to multi‐arm multi‐stage platform trials in progress Thomas Burnett Franz König Thomas Jaki Statistics in Medicine Adding experimental treatment arms to multi‐arm multi‐stage platform trials in progress Thomas Burnett Franz König Thomas Jaki Statistics in Medicine Multi‐arm multi‐stage (MAMS) platform trials efficiently compare several treatments with a common control arm. Crucially MAMS designs allow for adjustment for multiplicity if required. If for example, the active treatment arms in a clinical trial relate to different dose levels or different routes of administration of a drug, the strict control of the family‐wise error rate (FWER) is paramount. Suppose a further treatment becomes available, it is desirable to add this to the trial already in progress; to access both the practical and statistical benefits of the MAMS design. In any setting where control of the error rate is required, we must add corresponding hypotheses without compromising the validity of the testing procedure.To strongly control the FWER, MAMS designs use pre‐planned decision rules that determine the recruitment of the next stage of the trial based on the available data. The addition of a treatment arm presents an unplanned change to the design that we must account for in the testing procedure. We demonstrate the use of the conditional error approach to add hypotheses to any testing procedure that strongly controls the FWER. We use this framework to add treatments to a MAMS trial in progress. Simulations illustrate the possible characteristics of such procedures. 10.1002/sim.10090 http://creativecommons.org/licenses/by/4.0/ |
| title | Adding experimental treatment arms to multi‐arm multi‐stage platform trials in progress |
| topic | Statistics in Medicine |
| url | https://onlinelibrary.wiley.com/doi/10.1002/sim.10090 |