Generalized Estimating Equations for Survival Data With Dependent Censoring

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Main Authors: Lili Yu, Liang Liu
Format: Artículo Open Access
Published: Wiley 2024
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author Lili Yu
Liang Liu
author_facet Lili Yu
Liang Liu
Lili Yu
Liang Liu
collection Wiley Open Access
contents Generalized Estimating Equations for Survival Data With Dependent Censoring Lili Yu Liang Liu Statistics in Medicine ABSTRACTIndependent censoring is usually assumed in survival data analysis. However, dependent censoring, where the survival time is dependent on the censoring time, is often seen in real data applications. In this project, we model the vector of survival time and censoring time marginally through semiparametric heteroscedastic accelerated failure time models and model their association by the vector of errors in the model. We show that this semiparametric model is identified, and the generalized estimating equation approach is extended to estimate the parameters in this model. It is shown that the estimators of the model parameters are consistent and asymptotically normal. Simulation studies are conducted to compare it with the estimation method under a parametric model. A real dataset from a prostate cancer study is used for illustration of the new proposed method. 10.1002/sim.10296 http://onlinelibrary.wiley.com/termsAndConditions#vor
doi_str_mv 10.1002/sim.10296
format Artículo Open Access
id wiley_oa_10_1002_sim_10296
institution Wiley Open Access
license_str_mv http://onlinelibrary.wiley.com/termsAndConditions#vor
publishDate 2024
publisher Wiley
record_format wiley_oa
spellingShingle Generalized Estimating Equations for Survival Data With Dependent Censoring
Lili Yu
Liang Liu
Statistics in Medicine
Generalized Estimating Equations for Survival Data With Dependent Censoring Lili Yu Liang Liu Statistics in Medicine ABSTRACTIndependent censoring is usually assumed in survival data analysis. However, dependent censoring, where the survival time is dependent on the censoring time, is often seen in real data applications. In this project, we model the vector of survival time and censoring time marginally through semiparametric heteroscedastic accelerated failure time models and model their association by the vector of errors in the model. We show that this semiparametric model is identified, and the generalized estimating equation approach is extended to estimate the parameters in this model. It is shown that the estimators of the model parameters are consistent and asymptotically normal. Simulation studies are conducted to compare it with the estimation method under a parametric model. A real dataset from a prostate cancer study is used for illustration of the new proposed method. 10.1002/sim.10296 http://onlinelibrary.wiley.com/termsAndConditions#vor
title Generalized Estimating Equations for Survival Data With Dependent Censoring
topic Statistics in Medicine
url https://onlinelibrary.wiley.com/doi/10.1002/sim.10296