Prevalence of nonalcoholic fatty liver disease and liver cirrhosis in Chinese adults with type 2 diabetes mellitus
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| Format: | Artículo Open Access |
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2024
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| _version_ | 1867003391060738048 |
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| author | Xinyu Han Xin Zhang Zhenqiu Liu Hong Fan Chengnan Guo Haili Wang Yu Gu Tiejun Zhang |
| author_facet | Xinyu Han Xin Zhang Zhenqiu Liu Hong Fan Chengnan Guo Haili Wang Yu Gu Tiejun Zhang Xinyu Han Xin Zhang Zhenqiu Liu Hong Fan Chengnan Guo Haili Wang Yu Gu Tiejun Zhang |
| collection | Wiley Open Access |
| contents | Prevalence of nonalcoholic fatty liver disease and liver cirrhosis in Chinese adults with type 2 diabetes mellitus Xinyu Han Xin Zhang Zhenqiu Liu Hong Fan Chengnan Guo Haili Wang Yu Gu Tiejun Zhang Journal of Diabetes AbstractBackgroundNonalcoholic fatty liver disease (NAFLD) and liver cirrhosis are significant clinical concerns, especially among individuals with type 2 diabetes mellitus (T2DM). However, in China, there is a paucity of reliable evidence detailing the characteristics of NAFLD and liver cirrhosis in T2DM. Furthermore, the relationship between blood glucose levels and NAFLD prevalence remains unclear.MethodsData from the Shanghai Suburban Adult Cohort and Biobank were analyzed, including 6621 participants with T2DM. NAFLD was diagnosed by ultrasonography and liver cirrhosis was performed according to the health information systems. Logistic regression and restricted cubic spline analysis were used to explore the potential risk factors for NAFLD and liver cirrhosis.ResultsThe prevalence of NAFLD was 59.36%, and liver cirrhosis was 1.43% among T2DM patients. In these patients, factors like age, being female, marital status, and obesity significantly increased the risk of NAFLD. Specifically, obesity had a strong positive association with NAFLD (odds ratio [OR] = 4.70, 95% confidence interval [CI]: 4.13–5.34). The higher glycated hemoglobin (HbA1c) quartile was associated with a heightened NAFLD risk compared to the lowest quartile (all p < .001). The HbA1c‐NAFLD relationship displayed a linear that mimicked an inverted L‐shaped pattern. A significant positive association existed between HbA1c levels and NAFLD for HbA1c <8.00% (OR = 1.59, 95% CI: 1.44–1.75), but this was not observed for HbA1c >8.00% (OR = 1.03, 95% CI: 0.92–1.15).ConclusionSystematic screening for NAFLD is essential in T2DM patients, especially with poor glucose control and obesity in female.image 10.1111/1753-0407.13564 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/1753-0407.13564 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_1753_0407_13564 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Prevalence of nonalcoholic fatty liver disease and liver cirrhosis in Chinese adults with type 2 diabetes mellitus Xinyu Han Xin Zhang Zhenqiu Liu Hong Fan Chengnan Guo Haili Wang Yu Gu Tiejun Zhang Journal of Diabetes Prevalence of nonalcoholic fatty liver disease and liver cirrhosis in Chinese adults with type 2 diabetes mellitus Xinyu Han Xin Zhang Zhenqiu Liu Hong Fan Chengnan Guo Haili Wang Yu Gu Tiejun Zhang Journal of Diabetes AbstractBackgroundNonalcoholic fatty liver disease (NAFLD) and liver cirrhosis are significant clinical concerns, especially among individuals with type 2 diabetes mellitus (T2DM). However, in China, there is a paucity of reliable evidence detailing the characteristics of NAFLD and liver cirrhosis in T2DM. Furthermore, the relationship between blood glucose levels and NAFLD prevalence remains unclear.MethodsData from the Shanghai Suburban Adult Cohort and Biobank were analyzed, including 6621 participants with T2DM. NAFLD was diagnosed by ultrasonography and liver cirrhosis was performed according to the health information systems. Logistic regression and restricted cubic spline analysis were used to explore the potential risk factors for NAFLD and liver cirrhosis.ResultsThe prevalence of NAFLD was 59.36%, and liver cirrhosis was 1.43% among T2DM patients. In these patients, factors like age, being female, marital status, and obesity significantly increased the risk of NAFLD. Specifically, obesity had a strong positive association with NAFLD (odds ratio [OR] = 4.70, 95% confidence interval [CI]: 4.13–5.34). The higher glycated hemoglobin (HbA1c) quartile was associated with a heightened NAFLD risk compared to the lowest quartile (all p < .001). The HbA1c‐NAFLD relationship displayed a linear that mimicked an inverted L‐shaped pattern. A significant positive association existed between HbA1c levels and NAFLD for HbA1c <8.00% (OR = 1.59, 95% CI: 1.44–1.75), but this was not observed for HbA1c >8.00% (OR = 1.03, 95% CI: 0.92–1.15).ConclusionSystematic screening for NAFLD is essential in T2DM patients, especially with poor glucose control and obesity in female.image 10.1111/1753-0407.13564 http://creativecommons.org/licenses/by/4.0/ |
| title | Prevalence of nonalcoholic fatty liver disease and liver cirrhosis in Chinese adults with type 2 diabetes mellitus |
| topic | Journal of Diabetes |
| url | https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.13564 |