Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study
Fuente:
Wiley Open Access
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2024
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1867006672944234496 |
|---|---|
| author | Yahao Wang Yixuan Li Chuanfeng Liu Yangang Wang Yiming Li |
| author_facet | Yahao Wang Yixuan Li Chuanfeng Liu Yangang Wang Yiming Li Yahao Wang Yixuan Li Chuanfeng Liu Yangang Wang Yiming Li |
| collection | Wiley Open Access |
| contents | Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study Yahao Wang Yixuan Li Chuanfeng Liu Yangang Wang Yiming Li Journal of Diabetes AbstractBackgroundIt is known that the risk of ischemic heart disease increases in patients with type 2 diabetes mellitus (T2DM). For female patients, the incidence of heart disease can be even greater after menopause, accompanied by dramatic changes in sex hormones. We investigated the correlations between sex hormones and markers of ischemic heart diseases in postmenopausal females with T2DM patients.MethodsThis cross‐sectional study collected data from 324 hospitalized postmenopausal females with T2DM. Multiple linear regression analyses were conducted to determine the correlations between sex hormones and cardiac markers including high‐sensitive cardiac troponin T (hs‐cTnT) and N‐terminal prohormone of brain natriuretic peptide (NT‐proBNP) levels.ResultsMultiple linear regression analyses revealed that luteinizing hormone (LH) was positively and independently associated with hs‐cTnT concentrations in postmenopausal females with T2DM (β = 0.189, p = 0.002). Postmenopausal females with T2DM and subclinical myocardial injury had higher LH levels than those without subclinical myocardial injury (29.67 vs. 25.08 mIU/mL, p < 0.001). A multivariate logistic regression analysis confirmed an independent and significant association between elevated LH and subclinical myocardial injury in postmenopausal females with T2DM (adjusted odds ratio [OR] = 1.077, 95% confidence interval [CI], 1.033–1.124; p < 0.001). As another gonadotropin, the follicle‐stimulating hormone did not show independent correlations with hs‐cTnT or NT‐proBNP (p > 0.05). Neither estrogen nor testosterone was correlated with cardiac markers.ConclusionsElevated LH levels were positively and independently associated with increased hs‐cTnT levels in postmenopausal women with T2DM. Our findings suggest that LH could serve as a potential marker for assessing the risk of subclinical myocardial injury in postmenopausal females with T2DM.image 10.1111/1753-0407.70005 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/1753-0407.70005 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_1753_0407_70005 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study Yahao Wang Yixuan Li Chuanfeng Liu Yangang Wang Yiming Li Journal of Diabetes Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study Yahao Wang Yixuan Li Chuanfeng Liu Yangang Wang Yiming Li Journal of Diabetes AbstractBackgroundIt is known that the risk of ischemic heart disease increases in patients with type 2 diabetes mellitus (T2DM). For female patients, the incidence of heart disease can be even greater after menopause, accompanied by dramatic changes in sex hormones. We investigated the correlations between sex hormones and markers of ischemic heart diseases in postmenopausal females with T2DM patients.MethodsThis cross‐sectional study collected data from 324 hospitalized postmenopausal females with T2DM. Multiple linear regression analyses were conducted to determine the correlations between sex hormones and cardiac markers including high‐sensitive cardiac troponin T (hs‐cTnT) and N‐terminal prohormone of brain natriuretic peptide (NT‐proBNP) levels.ResultsMultiple linear regression analyses revealed that luteinizing hormone (LH) was positively and independently associated with hs‐cTnT concentrations in postmenopausal females with T2DM (β = 0.189, p = 0.002). Postmenopausal females with T2DM and subclinical myocardial injury had higher LH levels than those without subclinical myocardial injury (29.67 vs. 25.08 mIU/mL, p < 0.001). A multivariate logistic regression analysis confirmed an independent and significant association between elevated LH and subclinical myocardial injury in postmenopausal females with T2DM (adjusted odds ratio [OR] = 1.077, 95% confidence interval [CI], 1.033–1.124; p < 0.001). As another gonadotropin, the follicle‐stimulating hormone did not show independent correlations with hs‐cTnT or NT‐proBNP (p > 0.05). Neither estrogen nor testosterone was correlated with cardiac markers.ConclusionsElevated LH levels were positively and independently associated with increased hs‐cTnT levels in postmenopausal women with T2DM. Our findings suggest that LH could serve as a potential marker for assessing the risk of subclinical myocardial injury in postmenopausal females with T2DM.image 10.1111/1753-0407.70005 http://creativecommons.org/licenses/by/4.0/ |
| title | Luteinizing hormone is independently associated with high‐sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross‐sectional study |
| topic | Journal of Diabetes |
| url | https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.70005 |