Association Between Circulating Gremlin 2 and β‐Cell Function Among Participants With Prediabetes and Type 2 Diabetes
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2025
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| author | Mengshan Ni Yanru Chen Weiqiong Gu Yifei Zhang Min Xu Yanyun Gu Yufei Chen Yinmeng Zhu Xiao Wang Yaogan Luo Yu Xu Xu Lin Yi Arial Zeng Ruixin Liu Jiqiu Wang |
| author_facet | Mengshan Ni Yanru Chen Weiqiong Gu Yifei Zhang Min Xu Yanyun Gu Yufei Chen Yinmeng Zhu Xiao Wang Yaogan Luo Yu Xu Xu Lin Yi Arial Zeng Ruixin Liu Jiqiu Wang Mengshan Ni Yanru Chen Weiqiong Gu Yifei Zhang Min Xu Yanyun Gu Yufei Chen Yinmeng Zhu Xiao Wang Yaogan Luo Yu Xu Xu Lin Yi Arial Zeng Ruixin Liu Jiqiu Wang |
| collection | Wiley Open Access |
| contents | Association Between Circulating Gremlin 2 and β‐Cell Function Among Participants With Prediabetes and Type 2 Diabetes Mengshan Ni Yanru Chen Weiqiong Gu Yifei Zhang Min Xu Yanyun Gu Yufei Chen Yinmeng Zhu Xiao Wang Yaogan Luo Yu Xu Xu Lin Yi Arial Zeng Ruixin Liu Jiqiu Wang Journal of Diabetes ABSTRACTAimCirculating Gremlin 2 (Grem2) has recently been linked to human obesity, but its role in type 2 diabetes (T2D) remains unclear. This study aims to explore the association of circulating Grem2 with β‐cell function.MethodsA post hoc analysis was conducted using data from three clinical trials, in which all participants underwent the oral glucose tolerance test (OGTT). Circulating Grem2 levels were measured at 0, 1, and 2 h during the OGTT. In Trial 1, Grem2 levels were compared between participants with T2D (n = 59) and without T2D (n = 119). We further examined changes in Grem2 levels in response to oral antidiabetic drugs in participants with T2D in Trial 2 (n = 67) and calorie restriction in participants with prediabetes in Trial 3 (n = 231). The relationship between Grem2 levels and β‐cell function was analyzed across all trials.ResultsFasting and 1‐h Grem2 levels were lower in participants with T2D compared with those without T2D (728 ± 25 vs. 649 ± 31 pg/mL, p = 0.020; 631 ± 26 vs. 537 ± 31 pg/mL, p = 0.007). Fasting Grem2 levels were restored after antidiabetic treatment (550 ± 12 vs. 575 ± 12 pg/mL, p = 0.019), and 1‐h Grem2 levels increased following calorie restriction (1118 ± 89 vs. 1144 ± 90 vs. 1253 ± 89 pg/mL, p for trend = 0.002). The 1‐h Grem2 levels were positively associated with β‐cell function assessed by the oral disposition index and HOMA‐β.ConclusionReduced circulating Grem2 levels are associated with impaired β‐cell function in T2D, and could be restored through antidiabetic interventions.Trial Registration: ClinicalTrials.gov: NCT01959984, NCT01758471, NCT03856762 10.1111/1753-0407.70090 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/1753-0407.70090 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_1753_0407_70090 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Association Between Circulating Gremlin 2 and β‐Cell Function Among Participants With Prediabetes and Type 2 Diabetes Mengshan Ni Yanru Chen Weiqiong Gu Yifei Zhang Min Xu Yanyun Gu Yufei Chen Yinmeng Zhu Xiao Wang Yaogan Luo Yu Xu Xu Lin Yi Arial Zeng Ruixin Liu Jiqiu Wang Journal of Diabetes Association Between Circulating Gremlin 2 and β‐Cell Function Among Participants With Prediabetes and Type 2 Diabetes Mengshan Ni Yanru Chen Weiqiong Gu Yifei Zhang Min Xu Yanyun Gu Yufei Chen Yinmeng Zhu Xiao Wang Yaogan Luo Yu Xu Xu Lin Yi Arial Zeng Ruixin Liu Jiqiu Wang Journal of Diabetes ABSTRACTAimCirculating Gremlin 2 (Grem2) has recently been linked to human obesity, but its role in type 2 diabetes (T2D) remains unclear. This study aims to explore the association of circulating Grem2 with β‐cell function.MethodsA post hoc analysis was conducted using data from three clinical trials, in which all participants underwent the oral glucose tolerance test (OGTT). Circulating Grem2 levels were measured at 0, 1, and 2 h during the OGTT. In Trial 1, Grem2 levels were compared between participants with T2D (n = 59) and without T2D (n = 119). We further examined changes in Grem2 levels in response to oral antidiabetic drugs in participants with T2D in Trial 2 (n = 67) and calorie restriction in participants with prediabetes in Trial 3 (n = 231). The relationship between Grem2 levels and β‐cell function was analyzed across all trials.ResultsFasting and 1‐h Grem2 levels were lower in participants with T2D compared with those without T2D (728 ± 25 vs. 649 ± 31 pg/mL, p = 0.020; 631 ± 26 vs. 537 ± 31 pg/mL, p = 0.007). Fasting Grem2 levels were restored after antidiabetic treatment (550 ± 12 vs. 575 ± 12 pg/mL, p = 0.019), and 1‐h Grem2 levels increased following calorie restriction (1118 ± 89 vs. 1144 ± 90 vs. 1253 ± 89 pg/mL, p for trend = 0.002). The 1‐h Grem2 levels were positively associated with β‐cell function assessed by the oral disposition index and HOMA‐β.ConclusionReduced circulating Grem2 levels are associated with impaired β‐cell function in T2D, and could be restored through antidiabetic interventions.Trial Registration: ClinicalTrials.gov: NCT01959984, NCT01758471, NCT03856762 10.1111/1753-0407.70090 http://creativecommons.org/licenses/by/4.0/ |
| title | Association Between Circulating Gremlin 2 and β‐Cell Function Among Participants With Prediabetes and Type 2 Diabetes |
| topic | Journal of Diabetes |
| url | https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.70090 |