Periodontal Disease: A Contributing Factor to Adverse Outcome in Diabetes
Fuente:
Wiley Open Access
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Artículo Open Access |
| Veröffentlicht: |
Wiley
2025
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1867008010846470144 |
|---|---|
| author | Edgard El Chaar |
| author_facet | Edgard El Chaar Edgard El Chaar |
| collection | Wiley Open Access |
| contents | Periodontal Disease: A Contributing Factor to Adverse Outcome in Diabetes Edgard El Chaar Journal of Diabetes ABSTRACTPeriodontal disease is a prevalent and chronic inflammatory condition increasingly recognized for its systemic implications beyond oral health. While traditionally confined to dentistry, recent evidence reveals strong associations between periodontitis and chronic systemic conditions such as cardiovascular disease, diabetes mellitus, rheumatoid arthritis, inflammatory bowel disease, Alzheimer's disease, and various cancers. Mechanistic studies have identified plausible biological pathways, including systemic dissemination of periodontal pathogens and immune mediators, which can exacerbate distant organ inflammation and dysfunction. Experimental models highlight how oral bacteria influence immune responses, disrupt gut and vascular homeostasis, and contribute to oncogenesis and autoimmunity. Notably, bidirectional relationships, such as those between periodontitis and diabetes, underscore the need for integrated care approaches. Effective periodontal therapy has demonstrated systemic benefits, including improved glycemic control and reduced inflammation. Given the mounting evidence, periodontal disease should be approached as a critical component of systemic health, necessitating interdisciplinary collaboration among healthcare providers to optimize patient outcomes and public health. 10.1111/1753-0407.70136 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/1753-0407.70136 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_1753_0407_70136 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Periodontal Disease: A Contributing Factor to Adverse Outcome in Diabetes Edgard El Chaar Journal of Diabetes Periodontal Disease: A Contributing Factor to Adverse Outcome in Diabetes Edgard El Chaar Journal of Diabetes ABSTRACTPeriodontal disease is a prevalent and chronic inflammatory condition increasingly recognized for its systemic implications beyond oral health. While traditionally confined to dentistry, recent evidence reveals strong associations between periodontitis and chronic systemic conditions such as cardiovascular disease, diabetes mellitus, rheumatoid arthritis, inflammatory bowel disease, Alzheimer's disease, and various cancers. Mechanistic studies have identified plausible biological pathways, including systemic dissemination of periodontal pathogens and immune mediators, which can exacerbate distant organ inflammation and dysfunction. Experimental models highlight how oral bacteria influence immune responses, disrupt gut and vascular homeostasis, and contribute to oncogenesis and autoimmunity. Notably, bidirectional relationships, such as those between periodontitis and diabetes, underscore the need for integrated care approaches. Effective periodontal therapy has demonstrated systemic benefits, including improved glycemic control and reduced inflammation. Given the mounting evidence, periodontal disease should be approached as a critical component of systemic health, necessitating interdisciplinary collaboration among healthcare providers to optimize patient outcomes and public health. 10.1111/1753-0407.70136 http://creativecommons.org/licenses/by/4.0/ |
| title | Periodontal Disease: A Contributing Factor to Adverse Outcome in Diabetes |
| topic | Journal of Diabetes |
| url | https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.70136 |