No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study
Fuente:
Wiley Open Access
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1867005460508311553 |
|---|---|
| author | Brian T. Steffen Elizabeth R. Lusczek David R. Jacobs Chi Chen Venkatesh L. Murthy Linda Van Horn James G. Terry John Jeffrey Carr Lyn M. Steffen |
| author_facet | Brian T. Steffen Elizabeth R. Lusczek David R. Jacobs Chi Chen Venkatesh L. Murthy Linda Van Horn James G. Terry John Jeffrey Carr Lyn M. Steffen Brian T. Steffen Elizabeth R. Lusczek David R. Jacobs Chi Chen Venkatesh L. Murthy Linda Van Horn James G. Terry John Jeffrey Carr Lyn M. Steffen |
| collection | Wiley Open Access |
| contents | No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study Brian T. Steffen Elizabeth R. Lusczek David R. Jacobs Chi Chen Venkatesh L. Murthy Linda Van Horn James G. Terry John Jeffrey Carr Lyn M. Steffen Journal of Diabetes ABSTRACTBackgroundArtificial sweeteners have become ubiquitous additives in the food supply, and yet the safety of their regular consumption remains controversial. The present study examined whether intakes of aspartame or saccharin are related to aberrations in the plasma metabolome indicating disruptions in metabolism.MethodsA cohort of 2160 male and female participants, mean age 32.1 years, was included in the analysis. Liquid chromatography and mass‐spectrometry assessed 549 unique plasma metabolites. Diet was assessed using a validated questionnaire that allowed for estimation of aspartame and saccharin intakes. A generalized linear regression model evaluated associations of saccharin or aspartame intake with plasma metabolites with adjustment for potential confounders and multiple comparisons. Multiple sensitivity analyses and propensity score matching were conducted.ResultsHeavy aspartame intake (≥ 5 servings/day) was associated with plasma levels (per SD) of saccharin (β = 0.90; q = 9.0E‐36), myo‐inositol (β = 0.27; q = 3.7E‐04), caffeine (β = 0.31; q = 4.1E‐04), and five metabolites of caffeine including 1,7‐dimethyluric acid (β = 0.37; q = 7.1E‐06), 1‐methylurate (β = 0.36; q = 7.1E‐06), 5‐acetylamino‐6‐amino‐3‐methyluracil (β = 0.38; q = 3.2E‐6), theophylline (β = 0.36; q = 9.1E‐06), and 1‐methylxanthine (β = 0.32; q = 2.0E‐03). Saccharin intake was associated with plasma levels of saccharin alone (β = 0.29; q = 1.8E‐10). No associations with sugars, carbohydrates, lipids, amino acids, or other metabolites that would suggest metabolic perturbations were observed with either artificial sweetener; sensitivity analyses supported these findings.ConclusionsIn the largest metabolomics study to date, no link was found between metabolic disruptions and either aspartame or saccharin intake. We cannot exclude the possibility that more extreme intakes may be related to metabolic disruptions among consumers of artificial sweeteners. 10.1111/1753-0407.70138 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/1753-0407.70138 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_1753_0407_70138 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study Brian T. Steffen Elizabeth R. Lusczek David R. Jacobs Chi Chen Venkatesh L. Murthy Linda Van Horn James G. Terry John Jeffrey Carr Lyn M. Steffen Journal of Diabetes No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study Brian T. Steffen Elizabeth R. Lusczek David R. Jacobs Chi Chen Venkatesh L. Murthy Linda Van Horn James G. Terry John Jeffrey Carr Lyn M. Steffen Journal of Diabetes ABSTRACTBackgroundArtificial sweeteners have become ubiquitous additives in the food supply, and yet the safety of their regular consumption remains controversial. The present study examined whether intakes of aspartame or saccharin are related to aberrations in the plasma metabolome indicating disruptions in metabolism.MethodsA cohort of 2160 male and female participants, mean age 32.1 years, was included in the analysis. Liquid chromatography and mass‐spectrometry assessed 549 unique plasma metabolites. Diet was assessed using a validated questionnaire that allowed for estimation of aspartame and saccharin intakes. A generalized linear regression model evaluated associations of saccharin or aspartame intake with plasma metabolites with adjustment for potential confounders and multiple comparisons. Multiple sensitivity analyses and propensity score matching were conducted.ResultsHeavy aspartame intake (≥ 5 servings/day) was associated with plasma levels (per SD) of saccharin (β = 0.90; q = 9.0E‐36), myo‐inositol (β = 0.27; q = 3.7E‐04), caffeine (β = 0.31; q = 4.1E‐04), and five metabolites of caffeine including 1,7‐dimethyluric acid (β = 0.37; q = 7.1E‐06), 1‐methylurate (β = 0.36; q = 7.1E‐06), 5‐acetylamino‐6‐amino‐3‐methyluracil (β = 0.38; q = 3.2E‐6), theophylline (β = 0.36; q = 9.1E‐06), and 1‐methylxanthine (β = 0.32; q = 2.0E‐03). Saccharin intake was associated with plasma levels of saccharin alone (β = 0.29; q = 1.8E‐10). No associations with sugars, carbohydrates, lipids, amino acids, or other metabolites that would suggest metabolic perturbations were observed with either artificial sweetener; sensitivity analyses supported these findings.ConclusionsIn the largest metabolomics study to date, no link was found between metabolic disruptions and either aspartame or saccharin intake. We cannot exclude the possibility that more extreme intakes may be related to metabolic disruptions among consumers of artificial sweeteners. 10.1111/1753-0407.70138 http://creativecommons.org/licenses/by/4.0/ |
| title | No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study |
| topic | Journal of Diabetes |
| url | https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.70138 |