Long‐Term Effects of Intensive Lifestyle Intervention on Cardiometabolic Outcomes in Patients With Diabetes in Real‐World Clinical Practice: A 15‐Year Longitudinal Study
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2025
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| author | Abdelrahman Khater Marwa Al‐Badri Tareq Salah Shilton E. Dhaver Karim Kibaa Osama Hamdy |
| author_facet | Abdelrahman Khater Marwa Al‐Badri Tareq Salah Shilton E. Dhaver Karim Kibaa Osama Hamdy Abdelrahman Khater Marwa Al‐Badri Tareq Salah Shilton E. Dhaver Karim Kibaa Osama Hamdy |
| collection | Wiley Open Access |
| contents | Long‐Term Effects of Intensive Lifestyle Intervention on Cardiometabolic Outcomes in Patients With Diabetes in Real‐World Clinical Practice: A 15‐Year Longitudinal Study Abdelrahman Khater Marwa Al‐Badri Tareq Salah Shilton E. Dhaver Karim Kibaa Osama Hamdy Journal of Diabetes ABSTRACT Introduction We previously demonstrated that achieving and maintaining ≥ 7% weight loss at 1 year in patients with diabetes (DM), through multidisciplinary intensive lifestyle intervention (ILI) in real‐world clinical practice, predicts improvement in cardiometabolic outcomes at 5 and 10 years. In this prospective follow‐up, we report 15‐year results. Methods We evaluated 122 patients with DM and obesity (mean age 53.2 ± 10.0 years, 68% females, 90.2% type 2 DM, mean DM duration 9.1 ± 8.6 years, mean BMI 38.4 ± 5.2 kg/m 2 ) who completed a 12‐week ILI program. The cohort achieved an average weight loss of 10.7 ± 4.6 kg (−9.6%, p < 0.001) at 12 weeks and was divided into two groups at 1 year: group A, who maintained < 7% weight loss (47.5%) and group B, who maintained ≥ 7% weight loss (52.5%). Results At 15 years, the cohort maintained an average weight loss of 8.6 ± 11.9 kg (−7.6%, p < 0.001). Group B demonstrated superior sustained weight loss (12.9 ± 12.0 kg, −11.0%) compared to group A (3.8 ± 10.0 kg, −4.0%) with p < 0.001 between groups. A1C in group B improved from 7.3% ± 1.1% to 6.3% ± 0.8% at 12 weeks and remained at 7.3% ± 1.5% at 15 years, while group A's A1C increased from 6.7% ± 0.9% to 7.9% ± 1.8% ( p = 0.04 between groups). Both groups maintained LDL‐ and HDL‐cholesterol improvements, but group A experienced significant worsening of serum triglycerides. Conclusions ILI in real‐world clinical practice that results in ≥ 7% weight loss at 1 year in patients with DM and obesity is associated with continued improvement in cardiometabolic outcomes at 15 years. 10.1111/1753-0407.70153 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/1753-0407.70153 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_1753_0407_70153 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Long‐Term Effects of Intensive Lifestyle Intervention on Cardiometabolic Outcomes in Patients With Diabetes in Real‐World Clinical Practice: A 15‐Year Longitudinal Study Abdelrahman Khater Marwa Al‐Badri Tareq Salah Shilton E. Dhaver Karim Kibaa Osama Hamdy Journal of Diabetes Long‐Term Effects of Intensive Lifestyle Intervention on Cardiometabolic Outcomes in Patients With Diabetes in Real‐World Clinical Practice: A 15‐Year Longitudinal Study Abdelrahman Khater Marwa Al‐Badri Tareq Salah Shilton E. Dhaver Karim Kibaa Osama Hamdy Journal of Diabetes ABSTRACT Introduction We previously demonstrated that achieving and maintaining ≥ 7% weight loss at 1 year in patients with diabetes (DM), through multidisciplinary intensive lifestyle intervention (ILI) in real‐world clinical practice, predicts improvement in cardiometabolic outcomes at 5 and 10 years. In this prospective follow‐up, we report 15‐year results. Methods We evaluated 122 patients with DM and obesity (mean age 53.2 ± 10.0 years, 68% females, 90.2% type 2 DM, mean DM duration 9.1 ± 8.6 years, mean BMI 38.4 ± 5.2 kg/m 2 ) who completed a 12‐week ILI program. The cohort achieved an average weight loss of 10.7 ± 4.6 kg (−9.6%, p < 0.001) at 12 weeks and was divided into two groups at 1 year: group A, who maintained < 7% weight loss (47.5%) and group B, who maintained ≥ 7% weight loss (52.5%). Results At 15 years, the cohort maintained an average weight loss of 8.6 ± 11.9 kg (−7.6%, p < 0.001). Group B demonstrated superior sustained weight loss (12.9 ± 12.0 kg, −11.0%) compared to group A (3.8 ± 10.0 kg, −4.0%) with p < 0.001 between groups. A1C in group B improved from 7.3% ± 1.1% to 6.3% ± 0.8% at 12 weeks and remained at 7.3% ± 1.5% at 15 years, while group A's A1C increased from 6.7% ± 0.9% to 7.9% ± 1.8% ( p = 0.04 between groups). Both groups maintained LDL‐ and HDL‐cholesterol improvements, but group A experienced significant worsening of serum triglycerides. Conclusions ILI in real‐world clinical practice that results in ≥ 7% weight loss at 1 year in patients with DM and obesity is associated with continued improvement in cardiometabolic outcomes at 15 years. 10.1111/1753-0407.70153 http://creativecommons.org/licenses/by/4.0/ |
| title | Long‐Term Effects of Intensive Lifestyle Intervention on Cardiometabolic Outcomes in Patients With Diabetes in Real‐World Clinical Practice: A 15‐Year Longitudinal Study |
| topic | Journal of Diabetes |
| url | https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.70153 |