Cerebral Metabolic Rate of Oxygen and Accelerometry‐Based Fatigability in Community‐Dwelling Older Adults
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Wiley
2025
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| author | Emma L. Gay Caterina Rosano Paul M. Coen Nicholaas Bohnen Theodore Huppert Yujia (Susanna) Qiao Nancy W. Glynn |
| author_facet | Emma L. Gay Caterina Rosano Paul M. Coen Nicholaas Bohnen Theodore Huppert Yujia (Susanna) Qiao Nancy W. Glynn Emma L. Gay Caterina Rosano Paul M. Coen Nicholaas Bohnen Theodore Huppert Yujia (Susanna) Qiao Nancy W. Glynn |
| collection | Wiley Open Access |
| contents | Cerebral Metabolic Rate of Oxygen and Accelerometry‐Based Fatigability in Community‐Dwelling Older Adults Emma L. Gay Caterina Rosano Paul M. Coen Nicholaas Bohnen Theodore Huppert Yujia (Susanna) Qiao Nancy W. Glynn Aging Cell ABSTRACT Alterations in energy metabolism may drive fatigue in older age, but prior research primarily focused on skeletal muscle energetics without assessing other systems and utilized self‐reported measures of fatigue. We tested the association between energy metabolism in the brain and an objective measure of fatigability in the Study of Muscle, Mobility and Aging ( N = 119, age 76.8 ± 4.0 years, 59.7% women). Total brain cerebral metabolic rate of oxygen (CMRO 2 ) was measured using arterial spin labeling and T 2 ‐relaxation under spin tagging MRI protocols. Accelerometry‐based fatigability status during a fast‐paced 400 m walk was determined using the Pittsburgh Performance Fatigability Index (PPFI, higher = worse). Confounders included skeletal muscle energetics, measured in vivo using spectroscopy and ex vivo using respirometry, cardiorespiratory fitness (VO 2 peak), weight, medication count, and multimorbidity. Multivariable logistic regression models were used to estimate the association (odds ratio (OR)) of CMRO 2 with PPFI > 0 compared to the referent group PPFI = 0. Models were first adjusted for age and sex and further adjusted for confounders. In this sample, 41.2% had PPFI > 0 (median 3.3% [0.4%–8.0%]). Higher CMRO 2 was associated with exhibiting performance fatigability (age‐ and sex‐adjusted OR = 1.61, 95% CI: 1.06, 2.45, p = 0.03). This association remained significant after adjusting for in vivo skeletal muscle energetics and VO 2 peak, suggesting that performance fatigability is associated with multi‐system impairments in older adults. 10.1111/acel.70121 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/acel.70121 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_acel_70121 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Cerebral Metabolic Rate of Oxygen and Accelerometry‐Based Fatigability in Community‐Dwelling Older Adults Emma L. Gay Caterina Rosano Paul M. Coen Nicholaas Bohnen Theodore Huppert Yujia (Susanna) Qiao Nancy W. Glynn Aging Cell Cerebral Metabolic Rate of Oxygen and Accelerometry‐Based Fatigability in Community‐Dwelling Older Adults Emma L. Gay Caterina Rosano Paul M. Coen Nicholaas Bohnen Theodore Huppert Yujia (Susanna) Qiao Nancy W. Glynn Aging Cell ABSTRACT Alterations in energy metabolism may drive fatigue in older age, but prior research primarily focused on skeletal muscle energetics without assessing other systems and utilized self‐reported measures of fatigue. We tested the association between energy metabolism in the brain and an objective measure of fatigability in the Study of Muscle, Mobility and Aging ( N = 119, age 76.8 ± 4.0 years, 59.7% women). Total brain cerebral metabolic rate of oxygen (CMRO 2 ) was measured using arterial spin labeling and T 2 ‐relaxation under spin tagging MRI protocols. Accelerometry‐based fatigability status during a fast‐paced 400 m walk was determined using the Pittsburgh Performance Fatigability Index (PPFI, higher = worse). Confounders included skeletal muscle energetics, measured in vivo using spectroscopy and ex vivo using respirometry, cardiorespiratory fitness (VO 2 peak), weight, medication count, and multimorbidity. Multivariable logistic regression models were used to estimate the association (odds ratio (OR)) of CMRO 2 with PPFI > 0 compared to the referent group PPFI = 0. Models were first adjusted for age and sex and further adjusted for confounders. In this sample, 41.2% had PPFI > 0 (median 3.3% [0.4%–8.0%]). Higher CMRO 2 was associated with exhibiting performance fatigability (age‐ and sex‐adjusted OR = 1.61, 95% CI: 1.06, 2.45, p = 0.03). This association remained significant after adjusting for in vivo skeletal muscle energetics and VO 2 peak, suggesting that performance fatigability is associated with multi‐system impairments in older adults. 10.1111/acel.70121 http://creativecommons.org/licenses/by/4.0/ |
| title | Cerebral Metabolic Rate of Oxygen and Accelerometry‐Based Fatigability in Community‐Dwelling Older Adults |
| topic | Aging Cell |
| url | https://onlinelibrary.wiley.com/doi/10.1111/acel.70121 |