Cutaneous Infiltration of Waldenstrom's Macroglobulinaemia—A Two‐Case Series of a Diagnostically Challenging Presentation
Fuente:
Wiley Open Access
Salvato in:
| Autori principali: | , , , , , , |
|---|---|
| Natura: | Artículo Open Access |
| Pubblicazione: |
Wiley
2025
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1867015291658043392 |
|---|---|
| author | Monica Narula Patrick D. Mahar Edwin Wee Hian Tan Naveen Singh Stephen Lade Henry Miles Prince Christopher McCormack |
| author_facet | Monica Narula Patrick D. Mahar Edwin Wee Hian Tan Naveen Singh Stephen Lade Henry Miles Prince Christopher McCormack Monica Narula Patrick D. Mahar Edwin Wee Hian Tan Naveen Singh Stephen Lade Henry Miles Prince Christopher McCormack |
| collection | Wiley Open Access |
| contents | Cutaneous Infiltration of Waldenstrom's Macroglobulinaemia—A Two‐Case Series of a Diagnostically Challenging Presentation Monica Narula Patrick D. Mahar Edwin Wee Hian Tan Naveen Singh Stephen Lade Henry Miles Prince Christopher McCormack Australasian Journal of Dermatology ABSTRACT Background/Objectives Cutaneous manifestations of Waldenstrom's macroglobulinaemia (WM), a rare B‐cell lymphoproliferative disorder, present a diagnostic challenge. The intent of this article is to raise awareness to clinicians of a potentially overlooked condition, particularly in the context of patients with a monoclonal IgM paraproteinaemia, but also to describe the diagnostic complexity of the disease from a clinicopathological perspective. Methods We describe the clinical presentation and histopathological findings of two patients with cutaneous involvement of WM. Results Cutaneous presentations included erythematous and salmon pink plaques, which were either tender or non‐tender. Histopathology analysis in both cases demonstrated direct lymphocytic infiltration by malignant lymphocytes of WM, with case 1 demonstrating aberrant CD10 expression. Conclusion The broad cutaneous signs of WM are sparsely described in the literature, and these can even precede formal diagnosis. Ongoing clinical suspicion is warranted from both a clinical and histopathological perspective where patients present with a monoclonal IgM paraproteinemia. 10.1111/ajd.70021 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ajd.70021 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ajd_70021 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Cutaneous Infiltration of Waldenstrom's Macroglobulinaemia—A Two‐Case Series of a Diagnostically Challenging Presentation Monica Narula Patrick D. Mahar Edwin Wee Hian Tan Naveen Singh Stephen Lade Henry Miles Prince Christopher McCormack Australasian Journal of Dermatology Cutaneous Infiltration of Waldenstrom's Macroglobulinaemia—A Two‐Case Series of a Diagnostically Challenging Presentation Monica Narula Patrick D. Mahar Edwin Wee Hian Tan Naveen Singh Stephen Lade Henry Miles Prince Christopher McCormack Australasian Journal of Dermatology ABSTRACT Background/Objectives Cutaneous manifestations of Waldenstrom's macroglobulinaemia (WM), a rare B‐cell lymphoproliferative disorder, present a diagnostic challenge. The intent of this article is to raise awareness to clinicians of a potentially overlooked condition, particularly in the context of patients with a monoclonal IgM paraproteinaemia, but also to describe the diagnostic complexity of the disease from a clinicopathological perspective. Methods We describe the clinical presentation and histopathological findings of two patients with cutaneous involvement of WM. Results Cutaneous presentations included erythematous and salmon pink plaques, which were either tender or non‐tender. Histopathology analysis in both cases demonstrated direct lymphocytic infiltration by malignant lymphocytes of WM, with case 1 demonstrating aberrant CD10 expression. Conclusion The broad cutaneous signs of WM are sparsely described in the literature, and these can even precede formal diagnosis. Ongoing clinical suspicion is warranted from both a clinical and histopathological perspective where patients present with a monoclonal IgM paraproteinemia. 10.1111/ajd.70021 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Cutaneous Infiltration of Waldenstrom's Macroglobulinaemia—A Two‐Case Series of a Diagnostically Challenging Presentation |
| topic | Australasian Journal of Dermatology |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ajd.70021 |