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| Main Authors: | , , , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2024
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| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/andr.13607 |
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| _version_ | 1867006672870834176 |
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| author | Jaya K. Sharma Mandy E. Turner Amanda S. Paynter Patrick A. Norman Christine A. White Emilie C. Ward Michael A. Adams Rachel M. Holden |
| author_facet | Jaya K. Sharma Mandy E. Turner Amanda S. Paynter Patrick A. Norman Christine A. White Emilie C. Ward Michael A. Adams Rachel M. Holden Jaya K. Sharma Mandy E. Turner Amanda S. Paynter Patrick A. Norman Christine A. White Emilie C. Ward Michael A. Adams Rachel M. Holden |
| collection | Wiley Open Access |
| contents | Serum total testosterone is associated with phosphate and calcium excretion in response to oral phosphate loading in healthy middle‐aged males Jaya K. Sharma Mandy E. Turner Amanda S. Paynter Patrick A. Norman Christine A. White Emilie C. Ward Michael A. Adams Rachel M. Holden Andrology AbstractAndrogen receptors are expressed in the kidney and serum testosterone is negatively associated with serum phosphate in males, suggesting a role of testosterone in renal phosphate handling. In this cross‐sectional study, we examined the association of serum total and free testosterone with acute phosphate and calcium excretion in males in response to an oral phosphate challenge. Thirty‐five healthy adult males with normal baseline testosterone levels consumed a 500 mg phosphorus drink and the urinary excretion of minerals, as well as levels of relevant circulating parameters, were assessed at baseline and hourly for 4 h. Serum total testosterone was positively associated with overall phosphate excretion (r = 0.35, p = 0.04) and calcium excretion (r = 0.44, p = 0.00) in response to the challenge. Serum free testosterone was positively associated with post‐challenge calcium excretion (r = 0.34, p = 0.048), but significance was not reached for phosphate excretion (r = 0.31, p = 0.07). Serum total and free testosterone were not associated with parathyroid hormone, fibroblast growth factor‐23, or vitamin D—key factors implicated in phosphate and calcium regulation. Overall, higher serum total testosterone levels in healthy middle‐aged males are associated with a greater capacity to acutely excrete phosphate and calcium after a single oral phosphate challenge, suggesting potential ramifications of testosterone deficiency related to mineral homeostasis. 10.1111/andr.13607 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1111/andr.13607 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_andr_13607 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Serum total testosterone is associated with phosphate and calcium excretion in response to oral phosphate loading in healthy middle‐aged males Jaya K. Sharma Mandy E. Turner Amanda S. Paynter Patrick A. Norman Christine A. White Emilie C. Ward Michael A. Adams Rachel M. Holden Andrology Serum total testosterone is associated with phosphate and calcium excretion in response to oral phosphate loading in healthy middle‐aged males Jaya K. Sharma Mandy E. Turner Amanda S. Paynter Patrick A. Norman Christine A. White Emilie C. Ward Michael A. Adams Rachel M. Holden Andrology AbstractAndrogen receptors are expressed in the kidney and serum testosterone is negatively associated with serum phosphate in males, suggesting a role of testosterone in renal phosphate handling. In this cross‐sectional study, we examined the association of serum total and free testosterone with acute phosphate and calcium excretion in males in response to an oral phosphate challenge. Thirty‐five healthy adult males with normal baseline testosterone levels consumed a 500 mg phosphorus drink and the urinary excretion of minerals, as well as levels of relevant circulating parameters, were assessed at baseline and hourly for 4 h. Serum total testosterone was positively associated with overall phosphate excretion (r = 0.35, p = 0.04) and calcium excretion (r = 0.44, p = 0.00) in response to the challenge. Serum free testosterone was positively associated with post‐challenge calcium excretion (r = 0.34, p = 0.048), but significance was not reached for phosphate excretion (r = 0.31, p = 0.07). Serum total and free testosterone were not associated with parathyroid hormone, fibroblast growth factor‐23, or vitamin D—key factors implicated in phosphate and calcium regulation. Overall, higher serum total testosterone levels in healthy middle‐aged males are associated with a greater capacity to acutely excrete phosphate and calcium after a single oral phosphate challenge, suggesting potential ramifications of testosterone deficiency related to mineral homeostasis. 10.1111/andr.13607 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Serum total testosterone is associated with phosphate and calcium excretion in response to oral phosphate loading in healthy middle‐aged males |
| topic | Andrology |
| url | https://onlinelibrary.wiley.com/doi/10.1111/andr.13607 |