Cannabis exposure during pregnancy and perinatal outcomes: A cohort study
Fuente:
Wiley Open Access
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Veröffentlicht: |
Wiley
2024
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1867011043396419584 |
|---|---|
| author | Maia Brik Miguel Sandonis Alina Hernández‐Fleury Judit Gil Miriam Mota Francisco José Barranco Itziar Garcia Nerea Maiz Elena Carreras |
| author_facet | Maia Brik Miguel Sandonis Alina Hernández‐Fleury Judit Gil Miriam Mota Francisco José Barranco Itziar Garcia Nerea Maiz Elena Carreras Maia Brik Miguel Sandonis Alina Hernández‐Fleury Judit Gil Miriam Mota Francisco José Barranco Itziar Garcia Nerea Maiz Elena Carreras |
| collection | Wiley Open Access |
| contents | Cannabis exposure during pregnancy and perinatal outcomes: A cohort study Maia Brik Miguel Sandonis Alina Hernández‐Fleury Judit Gil Miriam Mota Francisco José Barranco Itziar Garcia Nerea Maiz Elena Carreras Acta Obstetricia et Gynecologica Scandinavica AbstractIntroductionCannabis potency and its use during pregnancy have increased in the last decade. The aim of this study was to investigate the impact of antenatal cannabis use on fetal growth, preterm birth and other perinatal outcomes.Material and methodsA propensity score‐matched analysis was performed in women with singleton pregnancies attending a tertiary care site in Barcelona. Women in the cannabis group were selected based on the results of a detection test. Primary outcomes were small for gestational age at birth (SGA), low birthweight and preterm birth. Secondary outcomes were other biometric parameters (neonatal length and head circumference), respiratory distress, admission to the neonatal intensive care unit and breastfeeding at discharge. A second propensity score‐matched analysis excluding other confounders (use of other recreational drugs and discontinuation of cannabis use during pregnancy) was performed.ResultsAntenatal cannabis was associated with a higher odds ratio of SGA (OR 3.60, 95% CI: 1.68–7.69), low birthweight (OR 3.94, 95% CI: 2.17–7.13), preterm birth at 37 weeks (OR 2.07, 95% CI: 1.12–3.84) and 32 weeks of gestation (OR 4.13, 95% CI: 1.06–16.11), admission to the neonatal intensive care unit (OR 1.95, 95% CI: 1.03–3.71), respiratory distress (OR 2.77, 95% CI: 1.26–6.34), and lower breastfeeding rates at discharge (OR 0.10, 95% CI: 0.05–0.18). When excluding other confounders, no significant association between antenatal cannabis use and SGA was found.ConclusionsAntenatal cannabis use increases the risk of SGA, low birthweight, preterm birth and other adverse perinatal outcomes. However, when isolating the impact of cannabis use by excluding women who use other recreational drugs and those who discontinue cannabis during pregnancy, no significant association between antenatal cannabis use and SGA birth was found. 10.1111/aogs.14818 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1111/aogs.14818 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_aogs_14818 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Cannabis exposure during pregnancy and perinatal outcomes: A cohort study Maia Brik Miguel Sandonis Alina Hernández‐Fleury Judit Gil Miriam Mota Francisco José Barranco Itziar Garcia Nerea Maiz Elena Carreras Acta Obstetricia et Gynecologica Scandinavica Cannabis exposure during pregnancy and perinatal outcomes: A cohort study Maia Brik Miguel Sandonis Alina Hernández‐Fleury Judit Gil Miriam Mota Francisco José Barranco Itziar Garcia Nerea Maiz Elena Carreras Acta Obstetricia et Gynecologica Scandinavica AbstractIntroductionCannabis potency and its use during pregnancy have increased in the last decade. The aim of this study was to investigate the impact of antenatal cannabis use on fetal growth, preterm birth and other perinatal outcomes.Material and methodsA propensity score‐matched analysis was performed in women with singleton pregnancies attending a tertiary care site in Barcelona. Women in the cannabis group were selected based on the results of a detection test. Primary outcomes were small for gestational age at birth (SGA), low birthweight and preterm birth. Secondary outcomes were other biometric parameters (neonatal length and head circumference), respiratory distress, admission to the neonatal intensive care unit and breastfeeding at discharge. A second propensity score‐matched analysis excluding other confounders (use of other recreational drugs and discontinuation of cannabis use during pregnancy) was performed.ResultsAntenatal cannabis was associated with a higher odds ratio of SGA (OR 3.60, 95% CI: 1.68–7.69), low birthweight (OR 3.94, 95% CI: 2.17–7.13), preterm birth at 37 weeks (OR 2.07, 95% CI: 1.12–3.84) and 32 weeks of gestation (OR 4.13, 95% CI: 1.06–16.11), admission to the neonatal intensive care unit (OR 1.95, 95% CI: 1.03–3.71), respiratory distress (OR 2.77, 95% CI: 1.26–6.34), and lower breastfeeding rates at discharge (OR 0.10, 95% CI: 0.05–0.18). When excluding other confounders, no significant association between antenatal cannabis use and SGA was found.ConclusionsAntenatal cannabis use increases the risk of SGA, low birthweight, preterm birth and other adverse perinatal outcomes. However, when isolating the impact of cannabis use by excluding women who use other recreational drugs and those who discontinue cannabis during pregnancy, no significant association between antenatal cannabis use and SGA birth was found. 10.1111/aogs.14818 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Cannabis exposure during pregnancy and perinatal outcomes: A cohort study |
| topic | Acta Obstetricia et Gynecologica Scandinavica |
| url | https://obgyn.onlinelibrary.wiley.com/doi/10.1111/aogs.14818 |