Association between prenatal glucocorticoid exposure and adolescent neurodevelopment: An observational follow‐up study
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Florian Rakers Ekkehard Schleussner Amani Cornelius Steffen Kluckow Isabel Muth Dirk Hoyer Sven Rupprecht Torsten Schultze Karin Schiecke Carolin Ligges Matthias Schwab Heike Hoyer |
| author_facet | Florian Rakers Ekkehard Schleussner Amani Cornelius Steffen Kluckow Isabel Muth Dirk Hoyer Sven Rupprecht Torsten Schultze Karin Schiecke Carolin Ligges Matthias Schwab Heike Hoyer Florian Rakers Ekkehard Schleussner Amani Cornelius Steffen Kluckow Isabel Muth Dirk Hoyer Sven Rupprecht Torsten Schultze Karin Schiecke Carolin Ligges Matthias Schwab Heike Hoyer |
| collection | Wiley Open Access |
| contents | Association between prenatal glucocorticoid exposure and adolescent neurodevelopment: An observational follow‐up study Florian Rakers Ekkehard Schleussner Amani Cornelius Steffen Kluckow Isabel Muth Dirk Hoyer Sven Rupprecht Torsten Schultze Karin Schiecke Carolin Ligges Matthias Schwab Heike Hoyer Acta Obstetricia et Gynecologica Scandinavica AbstractIntroductionPrenatal exposure to supraphysiological glucocorticoid (GC) levels may lead to long‐lasting developmental changes in numerous biological systems. Our prior study identified an association between prenatal GC prophylaxis and reduced cognitive performance, electrocortical changes, and altered autonomic nervous system (ANS) activity in children aged 8–9 years. This follow‐up study aimed to examine whether these findings persisted into adolescence.Material and MethodsProspective observational follow‐up study involving twenty‐one 14‐ to 15‐year‐old adolescents born to mothers who received betamethasone for induction of fetal lung maturation in threatened preterm birth, but who were born with a normal weight appropriate for their gestational age (median 37+4 gestational weeks). Thirty‐five children not exposed to betamethasone served as the reference group (median 37+6 gestational weeks). The primary endpoint was cognitive performance, measured by intelligence quotient (IQ). Key secondary endpoints included symptoms of attention‐deficit/hyperactivity disorder (ADHD) and metabolic markers. Additionally, we determined electrocortical (electroencephalogram), hypothalamus–pituitary–adrenal axis (HPAA), and ANS activity in response to a standardized stress paradigm.ResultsNo statistically significant group difference was observed in global IQ (adjusted mean: betamethasone 103.9 vs references 105.9, mean difference −2.0, 95% confidence interval [CI]: −7.12 to 3.12, p = 0.44). Similarly, ADHD symptoms, metabolic markers, the overall and stress‐induced activity of the HPAA and the ANS did not differ significantly between groups. However, the betamethasone group exhibited reduced electrocortical activity in the frontal brain region (spectral edge frequency–adjusted means: 16.0 Hz vs 17.8 Hz, mean difference −1.83 Hz, 95% CI: −3.21 to −0.45, p = 0.01).ConclusionsIn 14‐ to 15‐year‐old adolescents, prenatal GC exposure was not associated with differences in IQ scores or ANS activity compared to unexposed controls. However, decelerated electrocortical activity in the frontal region potentially reflects disturbances in the maturation of cortical and/or subcortical brain structures. The clinical significance of these changes remains unknown. Given the small sample size, selective participation/loss of follow‐up and potential residual confounding, these findings should be interpreted cautiously. Further research is required to replicate these results in larger cohorts before drawing firm clinical conclusions. 10.1111/aogs.14885 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1111/aogs.14885 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_aogs_14885 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Association between prenatal glucocorticoid exposure and adolescent neurodevelopment: An observational follow‐up study Florian Rakers Ekkehard Schleussner Amani Cornelius Steffen Kluckow Isabel Muth Dirk Hoyer Sven Rupprecht Torsten Schultze Karin Schiecke Carolin Ligges Matthias Schwab Heike Hoyer Acta Obstetricia et Gynecologica Scandinavica Association between prenatal glucocorticoid exposure and adolescent neurodevelopment: An observational follow‐up study Florian Rakers Ekkehard Schleussner Amani Cornelius Steffen Kluckow Isabel Muth Dirk Hoyer Sven Rupprecht Torsten Schultze Karin Schiecke Carolin Ligges Matthias Schwab Heike Hoyer Acta Obstetricia et Gynecologica Scandinavica AbstractIntroductionPrenatal exposure to supraphysiological glucocorticoid (GC) levels may lead to long‐lasting developmental changes in numerous biological systems. Our prior study identified an association between prenatal GC prophylaxis and reduced cognitive performance, electrocortical changes, and altered autonomic nervous system (ANS) activity in children aged 8–9 years. This follow‐up study aimed to examine whether these findings persisted into adolescence.Material and MethodsProspective observational follow‐up study involving twenty‐one 14‐ to 15‐year‐old adolescents born to mothers who received betamethasone for induction of fetal lung maturation in threatened preterm birth, but who were born with a normal weight appropriate for their gestational age (median 37+4 gestational weeks). Thirty‐five children not exposed to betamethasone served as the reference group (median 37+6 gestational weeks). The primary endpoint was cognitive performance, measured by intelligence quotient (IQ). Key secondary endpoints included symptoms of attention‐deficit/hyperactivity disorder (ADHD) and metabolic markers. Additionally, we determined electrocortical (electroencephalogram), hypothalamus–pituitary–adrenal axis (HPAA), and ANS activity in response to a standardized stress paradigm.ResultsNo statistically significant group difference was observed in global IQ (adjusted mean: betamethasone 103.9 vs references 105.9, mean difference −2.0, 95% confidence interval [CI]: −7.12 to 3.12, p = 0.44). Similarly, ADHD symptoms, metabolic markers, the overall and stress‐induced activity of the HPAA and the ANS did not differ significantly between groups. However, the betamethasone group exhibited reduced electrocortical activity in the frontal brain region (spectral edge frequency–adjusted means: 16.0 Hz vs 17.8 Hz, mean difference −1.83 Hz, 95% CI: −3.21 to −0.45, p = 0.01).ConclusionsIn 14‐ to 15‐year‐old adolescents, prenatal GC exposure was not associated with differences in IQ scores or ANS activity compared to unexposed controls. However, decelerated electrocortical activity in the frontal region potentially reflects disturbances in the maturation of cortical and/or subcortical brain structures. The clinical significance of these changes remains unknown. Given the small sample size, selective participation/loss of follow‐up and potential residual confounding, these findings should be interpreted cautiously. Further research is required to replicate these results in larger cohorts before drawing firm clinical conclusions. 10.1111/aogs.14885 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Association between prenatal glucocorticoid exposure and adolescent neurodevelopment: An observational follow‐up study |
| topic | Acta Obstetricia et Gynecologica Scandinavica |
| url | https://obgyn.onlinelibrary.wiley.com/doi/10.1111/aogs.14885 |