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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2025
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| Accès en ligne: | https://obgyn.onlinelibrary.wiley.com/doi/10.1111/aogs.70000 |
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- Metabolic associations of human placental lactogen in pregnancies at high metabolic risk: An observational cohort study Kate Rassie Simon Alesi Adriana C. H. Neven Taitum Mason Eveline Jona Stacey J. Ellery Joanne Enticott Aya Mousa Anju E. Joham David Simmons Helena Teede Acta Obstetricia et Gynecologica Scandinavica AbstractIntroductionHuman placental lactogen (hPL) is a placental hormone which, according to preclinical research, appears to have key metabolic roles in pregnancy. We aimed to examine pregnancy hPL levels in relation to maternal metabolic parameters and fetal outcomes within an ethnically diverse cohort at high metabolic risk. Design was an observational cohort study, nested within a randomized controlled trial.Material and MethodsPregnant women (n = 130), recruited for high metabolic risk, underwent measurement of hPL, plus clinical and metabolic parameters, in early pregnancy (15.8 ± 2.5 weeks of gestation). Univariable and multivariable simple linear regression models were used to examine relationships between early pregnancy hPL and key maternal anthropometric and biochemical variables. Fifty‐four women progressed to serial measurement of hPL and metabolic parameters across pregnancy. Univariable and multivariable mixed effects regression models were used to explore relationships between hPL and maternal variables across pregnancy, with repeated measures adjusted for using random effects.ResultsIn early pregnancy, lower hPL levels were independently associated with higher maternal fasting glucose (β = −1.03, p < 0.01). Early pregnancy hPL was not significantly related to maternal obesity, gestational diabetes mellitus (GDM), or polycystic ovary syndrome status. In women with GDM, sampled serially across pregnancy, maternal hPL and leptin levels were inversely associated (adjusted β = −0.098, p ≤ 0.001). There was a significant relationship between higher late pregnancy hPL and increased infant birthweight in the serially sampled GDM cohort, both before (β = 50.81, p = 0.01) and after (β = 41.78, p = 0.02) adjustment for gestational age at birth.ConclusionsMaternal hPL may play a role in maternal metabolic adaptation to pregnancy, particularly in relation to glucose and leptin dynamics. hPL in late pregnancy is positively associated with infant birthweight in women with GDM. Future studies of hPL in well‐defined contemporary populations are warranted, both to understand mechanistic interactions in pregnancy and potentially as a biomarker for infant birthweight. 10.1111/aogs.70000 http://creativecommons.org/licenses/by/4.0/