Cover Image

Time‐varying compartmental models capture hours‐scale variation in the elimination kinetics of vancomycin in rats

Fuente: Wiley Open Access

Saved in:

Bibliographic Details
Main Authors:	Matthew H. McDonough, Julian Gerson, Tod Kippin, Wendy Meiring, Kevin W. Plaxco
Format:	Artículo Open Access
Published:	Wiley 2025
Subjects:	British Journal of Pharmacology
Online Access:	Acceder al recurso
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain
by: Julian Gerson, et al.
Published: (2024)

Multifactorial attribution for vancomycin‐associated acute kidney injury
by: Yu‐Ling Tseng, et al.
Published: (2026)

Population pharmacokinetics of vancomycin in term neonates with perinatal asphyxia treated with therapeutic hypothermia
by: Marlotte A. A. van der Veer, et al.
Published: (2024)

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers
by: Vianney Tuloup, et al.
Published: (2026)

Pharmacokinetics of vancomycin in sputum of intubated patients: Optimized intravenous delivery vs. inhaled therapy
by: Lucy B. Palmer, et al.
Published: (2024)

Model‐informed vancomycin precision dosing by population pharmacokinetics combined with machine learning algorithms
by: Lei Shi, et al.
Published: (2026)

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children
by: Zoë Vander Elst, et al.
Published: (2026)

External evaluation of intravenous vancomycin population pharmacokinetic models in adults receiving high‐flux intermittent haemodialysis
by: Cheng Ji, et al.
Published: (2024)

Role of protein kinase A and A kinase anchoring proteins in buffering and compartmentation of cAMP signalling in human airway smooth muscle cells
by: Rinzhin T. Sherpa, et al.
Published: (2024)

A simulation study to assess the influence of population pharmacokinetic model selection on initial dosing recommendations of vancomycin in neonates
by: Mehdi El Hassani, et al.
Published: (2024)

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis
by: Laura Räisänen, et al.
Published: (2025)

Practical dose ranges supporting target vancomycin exposure with AUC‐guided dosing in overweight and obese patients: A multicentre retrospective study
by: Aiju Endo, et al.
Published: (2026)

Pharmacokinetics and pharmacodynamics of intranasal insulin in a rat brain
by: Jelena Osmanovic Barilar, et al.
Published: (2025)

Advances in binding kinetics and mechanistic PK/PD modelling
by: Bharath Srinivasan
Published: (2024)

Only time will tell: Modelling the kinetics of covalent inhibitors
by: Madeeha I. Ali, et al.
Published: (2026)

Sex influence on serotonergic modulation of the vascular noradrenergic drive in rats
by: Anaïs Clara Terol‐Úbeda, et al.
Published: (2024)

Sevoflurane protects against testicular ischaemia–reperfusion injury in rats
by: Jiaxue Li, et al.
Published: (2026)

The atypical antipsychotics lurasidone and olanzapine exert contrasting effects on the gut microbiome and metabolic function of rats
by: Srinivas Kamath, et al.
Published: (2024)

β 3 ‐adrenoceptor agonism exerts lung protection in a rat model of bronchopulmonary dysplasia
by: Alessandro Pini, et al.
Published: (2026)

Synergistic‐like decreases in alcohol intake following combined pharmacotherapy with GLP‐1 and amylin in male rats
by: Cajsa Aranäs, et al.
Published: (2024)

Contribution of peripheral and central delta opioid receptors in the relief of migraine‐like headache in female and male rats
by: Manon Dussol, et al.
Published: (2025)

Myo‐inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline‐induced pulmonary hypertension in the rat
by: Marta Oknińska, et al.
Published: (2024)

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes
by: Alberto Santiago‐Balmaseda, et al.
Published: (2026)

Correction to “Contribution of intercellular adhesion molecule 1 (ICAM‐1) to the pathogenesis of splanchnic artery occlusion shock in the rat”
Published: (2024)

MCF classifier: Estimating, standardizing, and stratifying medicine carbon footprints, at scale
by: Haroon Taylor, et al.
Published: (2024)

The opioid partial agonist PPL‐138 reduces alcohol self‐administration in rats susceptible to post‐traumatic stress disorder
by: Andrea Cippitelli, et al.
Published: (2025)

Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64 Cu PET/MRI
by: Emilie Munk Lynderup, et al.
Published: (2025)

Correction to Improved survival and reversal of endothelial dysfunction by the 21‐aminosteroid, U‐74389G in splanchnic ischaemia‐reperfusion injury in the rat
Published: (2024)

PDE4B inhibition by nerandomilast: Effects on lung fibrosis and transcriptome in fibrotic rats and on biomarkers in human lung epithelial cells
by: Dennis Reininger, et al.
Published: (2024)

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity
by: Takayuki Suzuki, et al.
Published: (2026)

Vortioxetine reduces the development of pain‐related behaviour in a knee osteoarthritis model in rats: Involvement of nerve growth factor (NGF) down‐regulation
by: Maja Tomić, et al.
Published: (2024)

Antiviral dose response against CMV infection varies with the timing of treatment initiation
by: L. Sudarsono, et al.
Published: (2025)

Feedback control of excitability and high K + induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A 1 receptor agonist
by: Erine Craey, et al.
Published: (2026)

Have plastic culture models prevented the discovery of effective cancer therapeutics?
by: Kevin M. Tharp
Published: (2024)

Gβγ subunit activation of K V 7 and BK Ca channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries
by: Lucy A. Donovan, et al.
Published: (2026)

Role of sacubitril/valsartan in testicular ischaemia reperfusion injury via modulation of AngII/ASK/NF‐κB and JAK/STAT pathways in juvenile rats
by: Marwa Monier Mahmoud Refaie, et al.
Published: (2025)

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion
by: Trang Tran, et al.
Published: (2025)

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats
by: Yu‐Te Lin, et al.
Published: (2024)

RETRACTION: L6H21 protects against cognitive impairment and brain pathologies via toll‐like receptor 4–myeloid differentiation factor 2 Signalling in Prediabetic rats
Published: (2025)

Preclinical pharmacokinetics of novel long‐acting tenofovir alafenamide/bictegravir solid injectable in rats
Published: (2024)