Copertina

Osthole targets doublecortin like kinase 1 (DCLK1/DCAMKL1) in macrophages to inhibit NF‐κB‐mediated inflammation and alleviate atherosclerosis

Fuente: Wiley Open Access

Salvato in:

Dettagli Bibliografici
Autori principali:	Sirui Shen, Wu Luo, Yue Guan, Yudie Yang, Pan Chen, Jiaqi Xu, Tong Zhou, Yongping Chen, Guang Liang
Natura:	Artículo Open Access
Pubblicazione:	Wiley 2026
Soggetti:	British Journal of Pharmacology
Accesso online:	Acceder al recurso
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi

Oroxylin A attenuates psoriasiform skin inflammation by direct targeting p62 (sequestosome 1) via suppressing M1 macrophage polarization
di: Yuxiang Ma, et al.
Pubblicazione: (2024)

Galangin alleviates vitiligo by targeting ANXA2 degradation in macrophages
di: Wenjing Wei, et al.
Pubblicazione: (2025)

RETRACTION: Ligand‐Induced Differentiation of Glucocorticoid Receptor (GR) Trans‐Repression and Transactivation: Preferential Targeting of NF‐κB and Lack of I‐κB Involvement
Pubblicazione: (2025)

The plant extract PNS mitigates atherosclerosis via promoting Nrf2‐mediated inhibition of ferroptosis through reducing USP2‐mediated Keap1 deubiquitination
di: Yun Zhao, et al.
Pubblicazione: (2024)

Beyond TGFβ inhibition: Chitosan oligosaccharide targets PGC‐1α‐mediated mitochondrial repair to combat pulmonary fibrosis
di: Huan He, et al.
Pubblicazione: (2025)

Ailanthone alleviates septic cardiomyopathy by attenuating MYST histone acetyltransferase 1 (MOF)‐mediated H4K16 lactylation‐driven inflammation
di: Yu Zhou, et al.
Pubblicazione: (2026)

Pharmacological targeting of large tumor suppressor kinases (LATS) 1 and 2 augments tissue repair and regeneration
di: Chen Xiao, et al.
Pubblicazione: (2025)

Enzyme‐responsive 612‐AYR nanoparticles for targeted inhibition of B4GALT3‐mediated ITGB1 glycosylation in hepatocellular carcinoma
di: Xiaohui Yu, et al.
Pubblicazione: (2026)

Anti‐chitinase‐3‐like 1 antibody attenuated atopic dermatitis‐like skin inflammation through inhibition of STAT3‐dependent CXCL8 expression
di: Ji Eun Yu, et al.
Pubblicazione: (2024)

Monocytic microRNAs—Novel targets in atherosclerosis therapy
di: Gerhild Euler, et al.
Pubblicazione: (2024)

GL‐V9 inhibits Caspase‐11 activation‐induced pyroptosis by suppressing ALOX12‐mediated lipid peroxidation to alleviate sepsis
di: Li Chen, et al.
Pubblicazione: (2025)

Monovalent glycoconjugates of sulforaphane prevent inflammation induced by lipopolysaccharide in human dendritic cells by inhibiting NF‐ĸB signalling pathway
di: Camila Leiva‐Castro, et al.
Pubblicazione: (2025)

Bruton's tyrosine kinase inhibition suppresses pathological retinal angiogenesis
di: Siyue Chen, et al.
Pubblicazione: (2024)

Berberine alleviates pre‐eclampsia by modulating M1/M2 macrophage polarization and T helper (Th1/Th2) cells cytokine balance
di: Ailan Yin, et al.
Pubblicazione: (2026)

Role of sacubitril/valsartan in testicular ischaemia reperfusion injury via modulation of AngII/ASK/NF‐κB and JAK/STAT pathways in juvenile rats
di: Marwa Monier Mahmoud Refaie, et al.
Pubblicazione: (2025)

Pharmacological inhibition of the interleukin‐1 receptor‐associated kinase prevents angiotensin II‐induced cardiac remodelling in mice
di: Shreya Jaiswal, et al.
Pubblicazione: (2026)

GI‐Y2, a novel gasdermin D inhibitor, attenuates sepsis‐induced myocardial dysfunction by inhibiting gasdermin D‐mediated pyroptosis in macrophages
di: Yiling Mei, et al.
Pubblicazione: (2025)

Tert‐butylhydroquinone promotes skin flap survival by inhibiting oxidative stress mediated by the Nrf2/HO‐1 signalling pathway
di: Kaitao Wang, et al.
Pubblicazione: (2024)

Nerandomilast, a PDE4B inhibitor, alleviates silica‐induced lung inflammation and fibrosis by inhibition of NLRP3 inflammasome and TGF‐β/Smad signalling
di: Yuanying Wang, et al.
Pubblicazione: (2025)

Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod‐induced psoriasiform inflammation via STAT1/S100A9 signalling pathway
di: Yi‐Wen Nie, et al.
Pubblicazione: (2025)

Targeting the tyrosine kinase Src in endothelium attenuates inflammation and atherogenesis induced by disturbed flow
di: Huanyu Ding, et al.
Pubblicazione: (2024)

AMG487 alleviates influenza A (H1N1) virus‐induced pulmonary inflammation through decreasing IFN‐γ‐producing lymphocytes and IFN‐γ concentrations
di: Wenbin Ding, et al.
Pubblicazione: (2024)

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice
di: Tábata Bergonci, et al.
Pubblicazione: (2026)

E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin‐dependent receptor‐interacting protein kinase 3 (RIP3) degradation
di: Jiatong Chen, et al.
Pubblicazione: (2025)

Ligustilide alleviates hepatic fibrosis by targeting the mesenchymal homeobox 1 (MEOX1)– transcriptional enhanced associate domain factor 2 (TEAD2) signalling axis
di: Qinrong Luan, et al.
Pubblicazione: (2026)

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases
di: Henning Olbrich, et al.
Pubblicazione: (2026)

Targeting noncoding RNAs to treat atherosclerosis
di: Miron Sopić, et al.
Pubblicazione: (2024)

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats
di: Yu‐Te Lin, et al.
Pubblicazione: (2024)

Off‐target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
di: Francisco Alejandro Lagunas‐Rangel, et al.
Pubblicazione: (2024)

Astragaloside II alleviates cardiac hypertrophy by targeting aminoacylase‐1: a novel mechanism via the β ‐catenin/transcription factor 4/ubiquitin C‐terminal hydrolase L1 axis
di: Yangyang Lin, et al.
Pubblicazione: (2026)

Genetic deficiency or pharmacological inhibition of cGAS–STING signalling suppresses kidney inflammation and fibrosis
di: Baihai Jiao, et al.
Pubblicazione: (2025)

IA‐0130, a novel 3‐(1,3‐diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL‐6/gp130/STAT3 signalling
di: Sun‐Ae Park, et al.
Pubblicazione: (2025)

Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis
di: Tamar Woudenberg, et al.
Pubblicazione: (2024)

Tryptophan 2,3‐dioxygenase deficiency attenuates dextran sodium sulphate –induced ulcerative colitis in mice by suppressing macrophage polarisation and reducing intestinal epithelial cell apoptosis
di: Weibo Dong, et al.
Pubblicazione: (2026)

Inhibition of the calcineurin/forkhead box O1/fatty acid binding protein 4 pathway prevents SERCA2 dysfunction‐induced foam cell formation and atherosclerosis
di: Beibei Zhu, et al.
Pubblicazione: (2025)

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy
di: Océane Pointeau, et al.
Pubblicazione: (2025)

Carvedilol inhibits neuronal hyperexcitability caused by epilepsy‐associated KCNT1 mutations
di: Chang Di, et al.
Pubblicazione: (2024)

Angiotensin‐(1‐7) alleviates intestinal barrier dysfunction and dysbiosis in mice with polymicrobial sepsis
di: Jun Wang, et al.
Pubblicazione: (2025)

A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages
di: Yue Ji, et al.
Pubblicazione: (2024)

S1P/S1PRs‐TRPV4 axis is a novel therapeutic target for persistent pain and itch in chronic dermatitis
di: Xinyu Zhang, et al.
Pubblicazione: (2024)