Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors
Fuente:
Wiley Open Access
Saved in:
| Main Authors: | Shivani Sachdev, Ross W. Cheloha |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2026
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation
by: Marta Lopez‐Balastegui, et al.
Published: (2024)
by: Marta Lopez‐Balastegui, et al.
Published: (2024)
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
by: Stephen P. H. Alexander, et al.
Published: (2025)
by: Stephen P. H. Alexander, et al.
Published: (2025)
Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain
by: Itziar Muneta‐Arrate, et al.
Published: (2024)
by: Itziar Muneta‐Arrate, et al.
Published: (2024)
Inhibition of TRPM8 function by prostacyclin receptor agonists requires coupling to Gq/11 proteins
by: Cosmin Trif, et al.
Published: (2024)
by: Cosmin Trif, et al.
Published: (2024)
Cholinergic G protein‐coupled bile acid receptor 1 (TGR5/GPBA) in the medial septal orchestrates adult hippocampal neurogenesis and cognition in Alzheimer's disease mice
by: Rui‐Zhe Nie, et al.
Published: (2025)
by: Rui‐Zhe Nie, et al.
Published: (2025)
Development of a generalized pharmacokinetic model to characterize clinical pharmacokinetics of monomethyl auristatin E‐based antibody–drug conjugates
by: Hsuan‐Ping Chang, et al.
Published: (2024)
by: Hsuan‐Ping Chang, et al.
Published: (2024)
Model‐informed dose selection for an investigational human epidermal growth factor receptor 2 antibody–drug conjugate FS‐1502 in patients with human epidermal growth factor receptor 2‐expressing advanced malignant solid tumours
by: Yi Sun, et al.
Published: (2024)
by: Yi Sun, et al.
Published: (2024)
A novel peptide‐fentanyl conjugate with μ‐opioid and neuropeptide FF receptor agonism produces antinociception with limited side effects in male mice
by: Ning Li, et al.
Published: (2025)
by: Ning Li, et al.
Published: (2025)
An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors
by: Kürsat Kirkgöz, et al.
Published: (2025)
by: Kürsat Kirkgöz, et al.
Published: (2025)
Transient receptor potential ankyrin 1 channel modulates the abuse‐related mechanisms of methamphetamine through interaction with dopamine transporter
by: Kwang‐Hyun Hur, et al.
Published: (2024)
by: Kwang‐Hyun Hur, et al.
Published: (2024)
Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells
by: Satoshi Asano, et al.
Published: (2025)
by: Satoshi Asano, et al.
Published: (2025)
Cathepsins: Novel opportunities for antibody therapeutics in cancer
by: Timothée David, et al.
Published: (2025)
by: Timothée David, et al.
Published: (2025)
Activation of peripheral cannabinoid receptors by CB13 attenuates burn injury–induced chronic pain through TRP channel modulation
by: Obulapathi Ummadisetty, et al.
Published: (2026)
by: Obulapathi Ummadisetty, et al.
Published: (2026)
Inhibition of peripheral CB 1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis
by: Oriane Onimus, et al.
Published: (2026)
by: Oriane Onimus, et al.
Published: (2026)
PLGA‐particle‐based vaccine induces SARS‐CoV‐2‐specific antibody and T‐cell responses
by: Dennis Horvath, et al.
Published: (2026)
by: Dennis Horvath, et al.
Published: (2026)
Correction to “Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression‐like behaviour in C57BL/6J mice”
Published: (2025)
Published: (2025)
Structural bases for stoichiometry‐selective calcium potentiation of a neuronal nicotinic receptor
by: Simone Mazzaferro, et al.
Published: (2024)
by: Simone Mazzaferro, et al.
Published: (2024)
Safety, pharmacokinetics and pharmacodynamics of NXC736, a novel sphingosine‐1‐phosphate receptor modulator
by: Woo Kyung Chung, et al.
Published: (2026)
by: Woo Kyung Chung, et al.
Published: (2026)
Pharmacology of PACAP and VIP receptors in the spinal cord highlights the importance of the PAC1 receptor
by: Zoe Tasma, et al.
Published: (2024)
by: Zoe Tasma, et al.
Published: (2024)
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential
by: Kelsey G. Guenther, et al.
Published: (2025)
by: Kelsey G. Guenther, et al.
Published: (2025)
Opioid receptors in cardiovascular function
by: Venkatesh Katari, et al.
Published: (2025)
by: Venkatesh Katari, et al.
Published: (2025)
Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats
by: Yu‐Te Lin, et al.
Published: (2024)
by: Yu‐Te Lin, et al.
Published: (2024)
Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage
by: Ivana Kuntić, et al.
Published: (2026)
by: Ivana Kuntić, et al.
Published: (2026)
Sex differences in the vasoactive effect of transient receptor potential channels: TRPM3 as a new therapeutic target for (neuro)vascular disorders
by: Eduardo Rivera‐Mancilla, et al.
Published: (2025)
by: Eduardo Rivera‐Mancilla, et al.
Published: (2025)
The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors
by: Stephen P. H. Alexander, et al.
Published: (2025)
by: Stephen P. H. Alexander, et al.
Published: (2025)
Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles
by: Denise Pajonczyk, et al.
Published: (2024)
by: Denise Pajonczyk, et al.
Published: (2024)
Chemistry/structural biology of psychedelic drugs and their receptor(s)
by: Ryan H. Gumpper, et al.
Published: (2024)
by: Ryan H. Gumpper, et al.
Published: (2024)
E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin‐dependent receptor‐interacting protein kinase 3 (RIP3) degradation
by: Jiatong Chen, et al.
Published: (2025)
by: Jiatong Chen, et al.
Published: (2025)
Preclinical and translational pharmacology of afucosylated anti‐CCR8 antibody for depletion of tumour‐infiltrating regulatory T cells
by: Gautham Gampa, et al.
Published: (2024)
by: Gautham Gampa, et al.
Published: (2024)
Expression of fibroblast growth factor receptor 1 correlates inversely with the efficacy of single‐agent fibroblast growth factor receptor‐specific inhibitors in pancreatic cancer
by: Qingxiang Lin, et al.
Published: (2024)
by: Qingxiang Lin, et al.
Published: (2024)
Inhibition of sphingosine‐1‐phosphate receptor‐2 attenuates chronic gastritis via blocking nuclear translocation of S1P 2 receptors in epithelial cells
by: Ke‐Qin Li, et al.
Published: (2025)
by: Ke‐Qin Li, et al.
Published: (2025)
The first in‐human study to evaluate the antiplatelet properties of the clopidogrel conjugate DT‐678 in acute coronary syndrome patients and healthy volunteers
by: Zhihao Liu, et al.
Published: (2024)
by: Zhihao Liu, et al.
Published: (2024)
Toll‐like receptor 4 mediates lipopolysaccharide‐induced emesis
by: Luping Liu, et al.
Published: (2026)
by: Luping Liu, et al.
Published: (2026)
Anti‐amyloid antibodies in Europe: Where are we now?
by: Danica Juricic Nahal, et al.
Published: (2026)
by: Danica Juricic Nahal, et al.
Published: (2026)
Butyrate acts as a positive allosteric modulator of the 5‐HT transporter to decrease availability of 5‐HT in the ileum
by: Jieling Cai, et al.
Published: (2024)
by: Jieling Cai, et al.
Published: (2024)
Drug‐likeness evaluation and inhibitory mechanism of the emodin derivative on cardiac fibrosis based on metastasis‐associated protein 3
by: Heng Liu, et al.
Published: (2025)
by: Heng Liu, et al.
Published: (2025)
Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits
by: Davide Malfacini, et al.
Published: (2026)
by: Davide Malfacini, et al.
Published: (2026)
The potential for biased signalling in the P2Y receptor family of GPCRs
by: Claudia M. Sisk, et al.
Published: (2025)
by: Claudia M. Sisk, et al.
Published: (2025)
Bioactive ligands targeting ectopic olfactory receptors: Implications for therapeutic strategies
by: Hui Zhao, et al.
Published: (2025)
by: Hui Zhao, et al.
Published: (2025)
A subtype‐selective photoswitchable agonist for precise manipulation of GABAA receptors
by: Simon Miguel M. Lopez, et al.
Published: (2025)
by: Simon Miguel M. Lopez, et al.
Published: (2025)
Similar Items
-
Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation
by: Marta Lopez‐Balastegui, et al.
Published: (2024) -
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
by: Stephen P. H. Alexander, et al.
Published: (2025) -
Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain
by: Itziar Muneta‐Arrate, et al.
Published: (2024) -
Inhibition of TRPM8 function by prostacyclin receptor agonists requires coupling to Gq/11 proteins
by: Cosmin Trif, et al.
Published: (2024) -
Cholinergic G protein‐coupled bile acid receptor 1 (TGR5/GPBA) in the medial septal orchestrates adult hippocampal neurogenesis and cognition in Alzheimer's disease mice
by: Rui‐Zhe Nie, et al.
Published: (2025)