Cytoplasmic Vacuolization: A Fascinating Morphological Alteration From Cellular Stress to Cell Death
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Wiley Open Access
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| Natura: | Artículo Open Access |
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Wiley
2025
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| _version_ | 1867012831672532992 |
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| author | Xiaoxu Wen Hongru Ma |
| author_facet | Xiaoxu Wen Hongru Ma Xiaoxu Wen Hongru Ma |
| collection | Wiley Open Access |
| contents | Cytoplasmic Vacuolization: A Fascinating Morphological Alteration From Cellular Stress to Cell Death Xiaoxu Wen Hongru Ma Cancer Science ABSTRACTCytoplasmic vacuolization is a cellular morphological alteration characterized by the presence of substantial vacuole‐like structures originating from various cellular organelles. This phenomenon is often observed in various anticancer treatments, including chemotherapeutic drugs, and photodynamic therapy (PDT), and is frequently linked with cell death. Nevertheless, the precise mechanisms underlying cytoplasmic vacuolization and ensuing cell death remain ambiguous. Cytoplasmic vacuolization associated cell death (CVACD) is a complex process characterized by cellular stress, encompassing ER stress, heightened membrane permeability, ion imbalance, and mitochondrial dysfunction. The MAPK signaling pathway is closely associated with the activation of CVACD. This review provides a thorough examination of contemporary studies on cytoplasmic vacuolization in mammalian cells, elucidating its etiology, origins, and molecular pathways. Additionally, it highlights the potential of CVACD as an innovative therapeutic strategy for cancer. 10.1111/cas.70013 http://creativecommons.org/licenses/by-nc/4.0/ |
| doi_str_mv | 10.1111/cas.70013 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cas_70013 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Cytoplasmic Vacuolization: A Fascinating Morphological Alteration From Cellular Stress to Cell Death Xiaoxu Wen Hongru Ma Cancer Science Cytoplasmic Vacuolization: A Fascinating Morphological Alteration From Cellular Stress to Cell Death Xiaoxu Wen Hongru Ma Cancer Science ABSTRACTCytoplasmic vacuolization is a cellular morphological alteration characterized by the presence of substantial vacuole‐like structures originating from various cellular organelles. This phenomenon is often observed in various anticancer treatments, including chemotherapeutic drugs, and photodynamic therapy (PDT), and is frequently linked with cell death. Nevertheless, the precise mechanisms underlying cytoplasmic vacuolization and ensuing cell death remain ambiguous. Cytoplasmic vacuolization associated cell death (CVACD) is a complex process characterized by cellular stress, encompassing ER stress, heightened membrane permeability, ion imbalance, and mitochondrial dysfunction. The MAPK signaling pathway is closely associated with the activation of CVACD. This review provides a thorough examination of contemporary studies on cytoplasmic vacuolization in mammalian cells, elucidating its etiology, origins, and molecular pathways. Additionally, it highlights the potential of CVACD as an innovative therapeutic strategy for cancer. 10.1111/cas.70013 http://creativecommons.org/licenses/by-nc/4.0/ |
| title | Cytoplasmic Vacuolization: A Fascinating Morphological Alteration From Cellular Stress to Cell Death |
| topic | Cancer Science |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cas.70013 |