Role of PD‐1 in Skin Cancer: Molecular Mechanism, Clinical Applications, and Resistance
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Wiley Open Access
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| Formato: | Artículo Open Access |
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Wiley
2024
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| _version_ | 1867015806772051968 |
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| author | Neha Sharma Rupa Mazumder Pallavi Rai Abhijit Debnath |
| author_facet | Neha Sharma Rupa Mazumder Pallavi Rai Abhijit Debnath Neha Sharma Rupa Mazumder Pallavi Rai Abhijit Debnath |
| collection | Wiley Open Access |
| contents | Role of PD‐1 in Skin Cancer: Molecular Mechanism, Clinical Applications, and Resistance Neha Sharma Rupa Mazumder Pallavi Rai Abhijit Debnath Chemical Biology & Drug Design ABSTRACTSkin cancer is a widespread worldwide health concern, manifesting in many subtypes such as squamous cell carcinoma, basal cell carcinoma, and melanoma. Although all these types occur frequently, they generally lack the possibility of being cured, emphasizing the importance of early discovery and treatment. This comprehensive study explores the role of programmed cell death protein 1 (PD‐1) in skin cancer, focusing on its molecular mechanisms in immune regulation and its critical role in tumor immune evasion, while also clarifying the complexities of immune checkpoints in cancer pathogenesis. It critically evaluates the clinical applications of PD‐1 inhibitors, spotlighting their therapeutic potential in treating skin cancer, while also addressing the significant challenge of resistance. This work further discusses the evolution of resistance mechanisms against PD‐1 inhibitors and suggests potential approaches to mitigate these issues, thereby enhancing the effectiveness of these therapies. The study further highlights the current state of PD‐1 targeted therapies and sets the stage for future research aimed at optimizing these treatments for better clinical outcomes in skin cancer. 10.1111/cbdd.14613 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/cbdd.14613 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cbdd_14613 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Role of PD‐1 in Skin Cancer: Molecular Mechanism, Clinical Applications, and Resistance Neha Sharma Rupa Mazumder Pallavi Rai Abhijit Debnath Chemical Biology & Drug Design Role of PD‐1 in Skin Cancer: Molecular Mechanism, Clinical Applications, and Resistance Neha Sharma Rupa Mazumder Pallavi Rai Abhijit Debnath Chemical Biology & Drug Design ABSTRACTSkin cancer is a widespread worldwide health concern, manifesting in many subtypes such as squamous cell carcinoma, basal cell carcinoma, and melanoma. Although all these types occur frequently, they generally lack the possibility of being cured, emphasizing the importance of early discovery and treatment. This comprehensive study explores the role of programmed cell death protein 1 (PD‐1) in skin cancer, focusing on its molecular mechanisms in immune regulation and its critical role in tumor immune evasion, while also clarifying the complexities of immune checkpoints in cancer pathogenesis. It critically evaluates the clinical applications of PD‐1 inhibitors, spotlighting their therapeutic potential in treating skin cancer, while also addressing the significant challenge of resistance. This work further discusses the evolution of resistance mechanisms against PD‐1 inhibitors and suggests potential approaches to mitigate these issues, thereby enhancing the effectiveness of these therapies. The study further highlights the current state of PD‐1 targeted therapies and sets the stage for future research aimed at optimizing these treatments for better clinical outcomes in skin cancer. 10.1111/cbdd.14613 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Role of PD‐1 in Skin Cancer: Molecular Mechanism, Clinical Applications, and Resistance |
| topic | Chemical Biology & Drug Design |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cbdd.14613 |