Copertina

Knowledgebase‐Driven Exploration and Experimental Verification of Simvastatin's Inhibitory Impact on P2X7/NLRP3 Inflammasome Pathway

Fuente: Wiley Open Access

Salvato in:

Dettagli Bibliografici
Autori principali:	Xinhai Wu, Chen‐Xin Guo, Sheng‐Feng Wang, Ting‐Ting Gong, Jing‐Wei Yao, Lin Hu, Zu‐Yue Deng, Lan Tang, Peng Xie, Zan Zhang, Yan Chen
Natura:	Artículo Open Access
Pubblicazione:	Wiley 2025
Soggetti:	Chemical Biology & Drug Design
Accesso online:	Acceder al recurso
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi

Echinacoside Alleviates Carbon Tetrachloride‐Induced Chronic Liver Injury by Modulating the NF‐κB/NLRP3 Inflammasome Pathway
di: Ye‐jun Yang, et al.
Pubblicazione: (2024)

Prunetin Protects Against Sepsis‐Induced Acute Lung Injury by Inhibiting Inflammation and Oxidative Stress via Regulating the TLR4 / NF ‐ κB / NLRP 3 Inflammasome Pathway
di: Xuedong Zhang, et al.
Pubblicazione: (2026)

Paeoniflorin Alleviates Pulmonary Arterial Hypertension by Suppressing TRIM24 ‐Mediated SIRT1 Ubiquitination and NLRP3 Inflammasome Activation
di: Jinbo Zhang, et al.
Pubblicazione: (2026)

Quercetin Prevents Hyperuricemia Associated With Gouty Arthritis by Inactivating the NLRP3/NF‐κB Signaling Pathway
di: Qingliang Meng, et al.
Pubblicazione: (2025)

Isoliquiritigenin attenuates neuroinflammation after subarachnoid hemorrhage through inhibition of NF‐κB‐mediated NLRP3 inflammasome activation
di: Zhang Wenfei, et al.
Pubblicazione: (2024)

Network Pharmacology‐Based Analysis and In Vitro Experiments Validation Reveal Tormentic Acid Induces Apoptosis via PI3K / AKT / HSP90 Pathway in HepG2 Cells
di: Jingyang Lu, et al.
Pubblicazione: (2026)

Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases
di: Chung‐Ting Kuo, et al.
Pubblicazione: (2026)

Plumbagin Triggers STING Pathway Activation to Suppress Non‐Small Cell Lung Cancer Progression
di: Li‐Ping Kang, et al.
Pubblicazione: (2025)

Inhibition Effects of Patchouli Alcohol, Carvacrol, p ‐Cymene, Eucalyptol and Their Formulations Against Influenza Virus Pneumonia Through TLR4 / NF ‐ κB / NLRP3 Signaling Pathway
di: Ruilin Lv, et al.
Pubblicazione: (2025)

Rutaecarpine Attenuates Ovalbumin‐Induced Asthma in Mice by Regulating the NF ‐ κB Pathway
di: Kongbo Chen, et al.
Pubblicazione: (2026)

Ferulic Acid Inhibits Partial Epithelial‐Mesenchymal Transition in Renal Tubular Epithelial Cells and Mitigates Renal Interstitial Fibrosis by Regulating the HIF‐1α/Twist Signaling Pathway
di: Lin Xu, et al.
Pubblicazione: (2025)

Identification of Autophagy‐Associated Molecular Signatures in Osteoarthritis Revealed by Integrative Multi‐Omics and Experimental Validation
di: Xiaoqing Wang, et al.
Pubblicazione: (2026)

Potential Mechanism of Qiju Dihuang Pill in Treating Primary Sjogren's Syndrome Revealed by Network Pharmacology and Experimental Verification
di: Huiying Wang, et al.
Pubblicazione: (2025)

Remimazolam attenuates inflammation in bronchopneumonia through the inhibition of NLRP3 activity by PDPK1 ubiquitination
di: Min Yang, et al.
Pubblicazione: (2024)

Arctigenin Modulates Adipogenic‐Osteogenic Balance in the Bone Marrow Microenvironment of Ovariectomized Rats via the MEK1/PPARγ/Wnt/β‐Catenin Pathway
di: Hongbo Li, et al.
Pubblicazione: (2024)

Computationally Driven Exploration of Novel bis‐Thiadiazole Sulfonamides as Alzheimer's Enzyme Inhibitors: A DFT and Kinetic Perspective
di: Farman Ullah, et al.
Pubblicazione: (2025)

Investigation of the Inhibitory Effects and Underlying Mechanisms of Vitexin Derivatives Targeting CDK1 in HCT Colorectal Cancer Cells
di: Ying Zhao, et al.
Pubblicazione: (2026)

Coumarin Analogues as Promising Anti‐Obesity Agents: In Silico Design, Synthesis, and In Vitro Pancreatic Lipase Inhibitory Activity
di: Nisha Yadav, et al.
Pubblicazione: (2025)

Identification of Mitophagy‐Related Genes With Diagnostic Value in Atherosclerosis Using Bioinformatics Analysis and Experiment Validation
di: Zhe Chen, et al.
Pubblicazione: (2026)

Antioxidant and Amylase, Glucosidase, and Tyrosinase Enzymes Inhibitory Potential of Genistein and 11‐α‐Hydroxyerysotrine Supported by In Silico and Network Pharmacology Approaches
di: Nouran M. Fahmy, et al.
Pubblicazione: (2025)

Apelin‐13's Actions in Controlling Hypertension‐Related Cardiac Hypertrophy and the Expressions of Inflammatory Cytokines
di: Xiaoliang Wei, et al.
Pubblicazione: (2024)

Berberine Ameliorates Pulmonary Fibrosis by Inactivating the Thrombospondin 2/Smad Homolog 2/3 Pathway
di: Liwen Zhang, et al.
Pubblicazione: (2025)

Role of Qufeng Tongqiao Prescription in the protection of cerebral ischemia and associated molecular network mechanism
di: Xue Bai, et al.
Pubblicazione: (2024)

Tetramethylpyrazine Targets HDAC6 ‐Mediated PINK1 Degradation to Alleviate Chronic Intermittent Hypoxia‐Induced Injury in Human Bronchial Epithelial Cells ( 16HBE )
di: Yanjie Chen, et al.
Pubblicazione: (2026)

Kisspeptin‐10 Improves Gestational Diabetes Mellitus Symptoms in Rats by Suppressing Insulin Resistance in Placental Trophoblast Cells by Activating the Cyclic AMP/Protein Kinase A Pathway
di: Jianhua Li, et al.
Pubblicazione: (2025)

Acacetin Attenuates Heatstroke‐Induced Acute Liver Injury by Targeting the c‐Jun/ PTGS2 Pathway
di: Xiaolong Shu, et al.
Pubblicazione: (2026)

Exploring the Mechanism of Myrrh in the Treatment of Breast Cancer Based on Network Pharmacology and Cell Experiments
di: Wu Tao, et al.
Pubblicazione: (2024)

Integrative Experimental Paradigm of Oxadiazole–Schiff Base Hybrids: Pharmacophore‐Driven Docking Simulations and DFT Insights Toward Antidiabetic Therapeutic Discovery
di: Aisha Bibi, et al.
Pubblicazione: (2026)

Prostaglandin E2 may clinically alleviate dry eye disease by inducing Th17 cell differentiation
di: Jingyao Chen, et al.
Pubblicazione: (2024)

Synthesis and Activity Study of Gefitinib Derivatives Inducing Mitochondrial Apoptosis in Hela Cells
di: Yue Li, et al.
Pubblicazione: (2024)

EGFR degraders in non‐small‐cell lung cancer: Breakthrough and unresolved issue
di: Jiayi Shen, et al.
Pubblicazione: (2024)

WGX ‐50 Promotes Healthy Ageing in Caenorhabditis elegans : A Combined Computational and Experimental Study
di: Guihua Jia, et al.
Pubblicazione: (2025)

Network Pharmacology Integrated Experimental Validation Uncover Quercetin as the Key Ingredient of Hedyotis diffusa Anti‐BRCA
di: Queting Chen, et al.
Pubblicazione: (2025)

Combination of Diosmetin With Chrysin Against Hepatocellular Carcinoma Through Inhibiting PI3K/AKT/mTOR/NF‐кB Signaling Pathway: TCGA Analysis, Molecular Docking, Molecular Dynamics, In Vitro Experiment
di: Xiang Yu, et al.
Pubblicazione: (2024)

Identification and Biological Evaluation of ( 4 H ‐Thieno[3,2‐ b ]indol‐3‐yl)methanol as a Tumoricidal Scaffold for an Antineoplastic Agent
di: Shi‐Hong Zhuang, et al.
Pubblicazione: (2025)

Structure‐Based Design of 2‐Aminopyrazolpyrimidopyridone Derivatives as New Rearranged During Transfection (RET) Kinase Inhibitors
di: Jiayi Shen, et al.
Pubblicazione: (2024)

Protective effect of naringin against radiation‐induced heart disease in rats via Sirt1/NF‐κB signaling pathway and endoplasmic reticulum stress
di: Shu‐Ting Liu, et al.
Pubblicazione: (2024)

Potential Modulatory Effects of Hesperidin on the JAK/STAT Pathway in Mesangial Proliferative Glomerulonephritis
di: Yingchun Tang, et al.
Pubblicazione: (2025)

Synthesis of Salidroside Derivatives at C4 Position of Benzene Ring and Its Effect on Hep3B Cell Viability
di: Juntao Wang, et al.
Pubblicazione: (2025)

Skullcapflavone II Suppresses Colorectal Cancer by Inhibiting the HIF ‐1α‐Glycolysis Pathway
di: Shiwei Yang, et al.
Pubblicazione: (2025)