Buchumschlag

Thienopyrimidine: Unveiling the Versatile Potential of a Promising Heterocyclic Scaffold in Drug Discovery

Fuente: Wiley Open Access

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Sahaya Nadar, Maheshkumar Borkar, Tabassum Khan
Format:	Artículo Open Access
Veröffentlicht:	Wiley 2025
Schlagworte:	Chemical Biology & Drug Design
Online-Zugang:	Acceder al recurso
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge

Prediction of Drug‐Induced Liver Injury: From Molecular Physicochemical Properties and Scaffold Architectures to Machine Learning Approaches
von: Yulong Zhao, et al.
Veröffentlicht: (2024)

Unveiling the Therapeutic Potential of Paclitaxel Combinations Against Breast Carcinoma and Identification of In Vivo Biomarkers
von: Aamir Mehmood, et al.
Veröffentlicht: (2024)

Exploring Thiazole‐Based Heterocycles: Synthesis, Bioactivity, and Molecular Docking for Antimicrobial Applications
von: Hana M. Abumelha, et al.
Veröffentlicht: (2025)

Identification of Potential PBP2a Inhibitors Against Methicillin‐Resistant Staphylococcus aureus via Drug Repurposing and Combination Therapy
von: Fangfang Jiao, et al.
Veröffentlicht: (2025)

Synthesis, Cytotoxic Activity, and Molecular Docking Study of New Thiazole‐Incorporated Indenopyridazine Derivatives as Potential Antiproliferative Drugs
von: Alaa M. Alqahtani, et al.
Veröffentlicht: (2025)

Correction to “Synthesis, Cytotoxic Activity, and Molecular Docking Study of New Thiazole‐Incorporated Indenopyridazine Derivatives as Potential Antiproliferative Drugs”
Veröffentlicht: (2025)

Old Drug, New Opportunity: Drug Repurposing in Cardiovascular Diseases
von: Xiuyi Ou, et al.
Veröffentlicht: (2026)

Integrative Experimental Paradigm of Oxadiazole–Schiff Base Hybrids: Pharmacophore‐Driven Docking Simulations and DFT Insights Toward Antidiabetic Therapeutic Discovery
von: Aisha Bibi, et al.
Veröffentlicht: (2026)

Synthesis, Biological Assay, and SAR of Potential Anticancer Lipophilic Fluoroquinolones ( FQs ) and Pyridoquinoxalines ( PQs ) Conjugated to Gold Nanoparticles for Synergistic and Proapoptogenic Cytotoxicity Drug Design and Targeted Delivery
von: Alaa Tabaza, et al.
Veröffentlicht: (2025)

Novel Triazole‐Linked Indole Derivatives as Potent Soluble Epoxy Hydrolase Inhibitors With Promising Anticancer Activity
von: Vijaykumar D. Nimbarte, et al.
Veröffentlicht: (2025)

From Virtual Screening to Cell Phenotype: 4‐Thiazolidone Scaffolds Targeting LOXL2 in Breast Cancer
von: Sandra Ferreira, et al.
Veröffentlicht: (2026)

Coumarin Analogues as Promising Anti‐Obesity Agents: In Silico Design, Synthesis, and In Vitro Pancreatic Lipase Inhibitory Activity
von: Nisha Yadav, et al.
Veröffentlicht: (2025)

Identification and Biological Evaluation of ( 4 H ‐Thieno[3,2‐ b ]indol‐3‐yl)methanol as a Tumoricidal Scaffold for an Antineoplastic Agent
von: Shi‐Hong Zhuang, et al.
Veröffentlicht: (2025)

Novel Silver(I) and Gold(I) N‐Heterocyclic Carbene Complexes Induce ROS ‐Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2
von: Rocchina Miglionico, et al.
Veröffentlicht: (2026)

Transformer‐Based Model for Drug Design and Therapy Response Prediction
von: Zheng Gu, et al.
Veröffentlicht: (2025)

Tyramine Derivatives as Versatile Pharmacophores With Potent Biological Properties: Sex Hormone–Binding Globulin Inhibition, Colon Cancer Antimigration, and Antimicrobial Activity
von: Jovana S. Marjanović, et al.
Veröffentlicht: (2024)

Machine Learning‐Based Discovery of a Novel Noncovalent MurA Inhibitor as an Antibacterial Agent
von: Qingxin Liu, et al.
Veröffentlicht: (2025)

Deep Learning for Drug–Target Interaction Prediction: A Comprehensive Review
von: Yingjun Chen, et al.
Veröffentlicht: (2025)

Discovery of Voreloxin as a Dual‐Selective Stabilizer for c‐Myc/Bcl‐2 G‐Quadruplexes in Leukemia
von: Jiacheng Yin, et al.
Veröffentlicht: (2024)

Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide
von: Isabella R. Palombi, et al.
Veröffentlicht: (2025)

Repurposing of FDA ‐Approved Drugs to Disrupt Iron Uptake in Mycobacterium abscessus : Targeting Salicylate Synthase as a Novel Approach
von: Giovanni Stelitano, et al.
Veröffentlicht: (2025)

Smart Immunoliposome‐Based Targeted Drug Delivery for Cancer: A Comprehensive Systematic Review
von: Gandhali Ghaisas, et al.
Veröffentlicht: (2026)

Multi‐Omics and Molecular Dynamics Analysis for Biomarker Discovery in Chronic Rhinosinusitis With Nasal Polyps
von: Qian Guo, et al.
Veröffentlicht: (2025)

Reviewing the IDH1 Mutation‐Mediated Mechanism of Drug Resistance and Revisiting Its Overcoming Strategies
von: Yifan Wang, et al.
Veröffentlicht: (2025)

A Comprehensive Review on the Advancements of Dual COX‐2/5‐LOX Inhibitors as Anti‐Inflammatory Drugs
von: Neetu Agrawal
Veröffentlicht: (2025)

Computationally Guided Structural Modification of Centaureidin: A Novel Approach for Enhancing Antioxidant and Antitumor Activities for Drug Development
von: Reem S. Alruhaimi, et al.
Veröffentlicht: (2025)

Therapeutic Potential of 6‐Gingerol in Glioma: Mechanistic Insights and Experimental Validation
von: Shan Miao, et al.
Veröffentlicht: (2025)

Discovery of Novel Oxadiazole‐Triazole Hybrids as Lung and Cervical Cancer Agents: Synthesis, Docking, Biological Evaluation, and SAR Studies
von: Venkatraman Hegde, et al.
Veröffentlicht: (2025)

Discovery of novel chromone and acrylate‐based pancreatic lipase inhibitors: Molecular modelling, synthesis, and in vitro evaluation for the treatment of obesity
von: Prashant S. Auti, et al.
Veröffentlicht: (2024)

Potential Modulatory Effects of Hesperidin on the JAK/STAT Pathway in Mesangial Proliferative Glomerulonephritis
von: Yingchun Tang, et al.
Veröffentlicht: (2025)

Targeting the Autophagy–Apoptosis Axis in Osteosarcoma: Therapeutic Potential of Biocompounds: A Review
von: Oznur Bayraktar Ekmekcigil, et al.
Veröffentlicht: (2026)

Investigation of Potential Inhibitors of N‐Myristoyltransferase in Leishmania amazonensis: A Computational and Experimental Study
von: Mariana Sant’Anna Pereira Nicolau, et al.
Veröffentlicht: (2025)

Beyond ATP Synthase Inhibition: Chemical Diversification, Bioactivities, and Therapeutic Potential of Oligomycin A
von: Mohamed S. Nafie, et al.
Veröffentlicht: (2025)

Correction to “Targeting the Autophagy–Apoptosis Axis in Osteosarcoma: Therapeutic Potential of Biocompounds: A Review”
Veröffentlicht: (2026)

Promotion Effect of Catalpol on Angiogenesis and Potential Mechanisms: A Research Based on Network Pharmacology
von: Jin‐rong Ni, et al.
Veröffentlicht: (2024)

Assessment of Antidiarrheal Activity of Fraxin in Chick: Synergistic Effects and Molecular Docking Study
von: Wahidul Alam, et al.
Veröffentlicht: (2026)

Sulfonyl Hydrazone Derivatives Targeting Glutathione Reductase: A Potential Strategy for Redox Modulation in Cancer
von: Erbay Kalay, et al.
Veröffentlicht: (2025)

Synthesis of Novel Soritin Sulfonamide Derivatives as Potential α‐Glucosidase Inhibitor and Their Molecular Docking Studies
von: Nurul Alam Inayatsyah, et al.
Veröffentlicht: (2024)

An AI ‐Guided Structure‐Based Strategy for the Discovery and Biological Validation of Natural Products Targeting the Vitamin D Receptor From YSQYP in Diabetic Kidney Disease
von: Xinze Liu, et al.
Veröffentlicht: (2026)

Multi‐Omics and Machine Learning‐Driven Discovery of ABCC8 ( SUR1 ) for Diabetes Mellitus: Integrating Molecular Insights on Nigella sativa Bioactives and Sulfonylurea
von: Mohd Adnan, et al.
Veröffentlicht: (2026)