Imagen de Portada

Advances in the Molecular Mechanism of Kappa Opioid Receptors Signaling and the Important Sampling Methods to Probe the Activation Landscape of GPCRs

Fuente: Wiley Open Access

Guardado en:

Detalles Bibliográficos
Autores principales:	Mingqiong Tong, Wan Sun, Pingxuan Dong, Jinghe Wang, Xiangling Gu, Zanxia Cao
Formato:	Artículo Open Access
Publicado:	Wiley 2025
Materias:	Chemical Biology & Drug Design
Acceso en línea:	Acceder al recurso
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Procyanidin Alleviates Diabetic Retinopathy by Activating the Expression of Activating Transcription Factor 1 Expression to Upregulate Synoviolin 1 and Inhibit the High Mobility Group Box 1/Toll‐Like Receptor 4 Pathway
por: Limin Zheng, et al.
Publicado: (2025)

Integrated Virtual Screening and Molecular Dynamics Simulation Study to Discover Potential Activators of γ‐Aminobutyric Acid B Receptor 1 for Therapeutic Targeting of Neurodegenerative Diseases
por: Asfiya, et al.
Publicado: (2026)

Role of PD‐1 in Skin Cancer: Molecular Mechanism, Clinical Applications, and Resistance
por: Neha Sharma, et al.
Publicado: (2024)

The Molecular Mechanism of Resveratrol in the Treatment of Chronic Rhinosinusitis Through a Combination of Network Pharmacology and In Vitro Validation
por: Xiao Cheng, et al.
Publicado: (2025)

Dl‐3‐n‐Butylphthalide Inhibits Autophagy to Alleviate the Neuronal Apoptosis After Spinal Cord Injury by Elevating YAP via Inactivating the Hippo Signaling Pathway
por: Shengsen Yang, et al.
Publicado: (2025)

Curcumin Regulates Microglia Polarization to Alleviate Ischemic Stroke by Targeting microRNA‐205‐5p/Kruppel‐Like Factor 2 (KLF2)/Activating Transcription Factor 2 (ATF2) Axis
por: Xiangyu Cao, et al.
Publicado: (2025)

Molecular Mechanism of Dexmedetomidine in Alzheimer's Disease: Machine Learning Identifies RGS7 as a Key Therapeutic Targe
por: Yangliang Yang, et al.
Publicado: (2025)

Morusin Reverses Epithelial‐Mesenchymal Transition in Gallbladder Cancer Cells by Regulating STAT3/HIF‐1α Signaling
por: Lichao Ji, et al.
Publicado: (2025)

Combination of Diosmetin With Chrysin Against Hepatocellular Carcinoma Through Inhibiting PI3K/AKT/mTOR/NF‐кB Signaling Pathway: TCGA Analysis, Molecular Docking, Molecular Dynamics, In Vitro Experiment
por: Xiang Yu, et al.
Publicado: (2024)

Molecular Mechanisms and Efficacy of Tislelizumab, a PD ‐1 Inhibitor Developed in China, in Non‐Small Cell Lung Cancer
por: Yihao Liu, et al.
Publicado: (2026)

Berberine Ameliorates Pulmonary Fibrosis via Downregulating the TGFBR2 ‐Mediated Signaling
por: Yichao Zhao, et al.
Publicado: (2026)

Network Pharmacology, Machine Learning, Molecular Docking, and Cell Experiments Reveal the Therapeutic Mechanism of Radix Rehmanniae Praeparata in Psoriasis In Vitro
por: Tingting Zhang, et al.
Publicado: (2026)

Erianin Protects Human Umbilical Vein Endothelial Cells From Oxidized Low‐Density Lipoprotein‐Induced Apoptosis and Oxidative Stress Through Activation of Nuclear Factor E2‐Related Factor 2 Signaling
por: Zhaowei Wang, et al.
Publicado: (2025)

In Silico and In Vitro Identification of New Eugenol Derivatives as Inhibitors of the Spike SARS ‐ CoV ‐2 Protein Interaction With the ACE2 Host Receptor
por: Timoteo Delgado‐Maldonado, et al.
Publicado: (2025)

An AI ‐Guided Structure‐Based Strategy for the Discovery and Biological Validation of Natural Products Targeting the Vitamin D Receptor From YSQYP in Diabetic Kidney Disease
por: Xinze Liu, et al.
Publicado: (2026)

Glutamine Attenuates Inflammation and Oxidative Stress in Ulcerative Colitis by Suppressing Wilms' Tumor 1 Associated Protein‐Mediated N6‐Methyladenosine Modification of Nuclear Receptor Coactivator 3
por: Liangxian Jiang, et al.
Publicado: (2025)

Transformer‐Based Model for Drug Design and Therapy Response Prediction
por: Zheng Gu, et al.
Publicado: (2025)

99mTc‐HYNIC PEGylated Peptide Probe Targeting HER2‐Expression in Breast Cancer
por: Sushree Arpitabala Yadav, et al.
Publicado: (2025)

Plumbagin Triggers STING Pathway Activation to Suppress Non‐Small Cell Lung Cancer Progression
por: Li‐Ping Kang, et al.
Publicado: (2025)

Discovery of 1‐(Cyclopropylmethyl)‐2‐(Dibenzo[b,d]Thiophen‐2‐yl)‐1H‐Benzo[d]Imidazole‐5‐Carboxylic Acid as Orally Bioavailable EP4 Receptor Antagonist
por: Sanjay Kumar, et al.
Publicado: (2025)

Systematic profiling of Taxol resistance and sensitivity to tubulin missence mutations at molecular and cellular levels
por: Lihua Zhou, et al.
Publicado: (2024)

Paeoniflorin Ameliorates Osteoarthritis via Ring Finger Protein 216/Optineurin‐Mediated Autophagy Activation in Chondrocytes
por: Cheng Peng, et al.
Publicado: (2026)

Exploring Thiazole‐Based Heterocycles: Synthesis, Bioactivity, and Molecular Docking for Antimicrobial Applications
por: Hana M. Abumelha, et al.
Publicado: (2025)

Assessment of Antidiarrheal Activity of Fraxin in Chick: Synergistic Effects and Molecular Docking Study
por: Wahidul Alam, et al.
Publicado: (2026)

Oridonin Alleviates Doxorubicin‐Induced Cardiotoxicity by Inhibiting p38 MAPK/MMP3 Signaling Pathway
por: Xingyuan Hou, et al.
Publicado: (2025)

Quercetin Prevents Hyperuricemia Associated With Gouty Arthritis by Inactivating the NLRP3/NF‐κB Signaling Pathway
por: Qingliang Meng, et al.
Publicado: (2025)

Multi‐Omics and Molecular Dynamics Analysis for Biomarker Discovery in Chronic Rhinosinusitis With Nasal Polyps
por: Qian Guo, et al.
Publicado: (2025)

Synthesis and Molecular Modeling Studies of New Thiadiazole‐Thiophene Compounds as Potent Antimicrobial Agents
por: Nuha M. Halawani, et al.
Publicado: (2025)

Protein Kinase Inhibitors: Synthesis and Molecular Repurposing in Three‐Dimensional Cancer Models PKI
por: Vladislav Lobanov, et al.
Publicado: (2025)

Paeoniflorin Alleviates Pulmonary Arterial Hypertension by Suppressing TRIM24 ‐Mediated SIRT1 Ubiquitination and NLRP3 Inflammasome Activation
por: Jinbo Zhang, et al.
Publicado: (2026)

Rutecarpine Suppresses Non‐Small Cell Lung Cancer Progression Through Activating the STING Pathway and Elevating CD8+ T Cells
por: Ze‐Bo Jiang, et al.
Publicado: (2025)

Forsythiaside A Ameliorates Oxidative Damage Caused by Cerebral Ischemia Through the Nrf2/HO‐1 Signaling Pathway
por: Wei Li, et al.
Publicado: (2025)

Synthesis of Novel Soritin Sulfonamide Derivatives as Potential α‐Glucosidase Inhibitor and Their Molecular Docking Studies
por: Nurul Alam Inayatsyah, et al.
Publicado: (2024)

Synthesis of New Thiazole‐Pyrazole Analogues: Molecular Modelling, Antiproliferative/Antiviral Activities, and ADME Studies
por: Hind A. Siddiq, et al.
Publicado: (2025)

Identification of Autophagy‐Associated Molecular Signatures in Osteoarthritis Revealed by Integrative Multi‐Omics and Experimental Validation
por: Xiaoqing Wang, et al.
Publicado: (2026)

Embelin Elevates Endoplasmic Reticulum Calcium Levels and Blocks the Sterol Regulatory Element‐Binding Protein 2 Mediated Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Improves the Low‐Density Lipoprotein Receptor Mediated Lipid Clearance on Hepatocytes
por: Mahesh Chandran, et al.
Publicado: (2025)

The Therapeutic Effect and Mechanism of Vismodegib on COPD : Focusing on NETs and Macrophage Polarization
por: Ming Wu, et al.
Publicado: (2026)

Madecassoside Induces Apoptosis and Inhibits Migration by Regulating ROS ‐Mediated Signaling Pathways in MDA ‐ MB ‐231 Breast Cancer Cells
por: Wen‐Shuang Hou, et al.
Publicado: (2025)

Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases
por: Chung‐Ting Kuo, et al.
Publicado: (2026)

Small Molecule Inhibitors Targeting Cdc2‐Like Kinase 4: Advances, Challenges, and Opportunities
por: Yu Jiang, et al.
Publicado: (2025)