Copertina

Targeting the Elongin BC – BC ‐Box Interface: Structural Insights, Peptidic Disruptors and Emerging Small‐Molecule Strategies

Fuente: Wiley Open Access

Salvato in:

Dettagli Bibliografici
Autori principali:	Emadeldin M. Kamel, Sally Mostafa Khadrawy, Ahmed A. Allam, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi
Natura:	Artículo Open Access
Pubblicazione:	Wiley 2026
Soggetti:	Chemical Biology & Drug Design
Accesso online:	Acceder al recurso
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!

Documenti analoghi

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer
di: Emadeldin M. Kamel, et al.
Pubblicazione: (2025)

Computationally Guided Structural Modification of Centaureidin: A Novel Approach for Enhancing Antioxidant and Antitumor Activities for Drug Development
di: Reem S. Alruhaimi, et al.
Pubblicazione: (2025)

Natural Product Modulators of Protein–Protein Interactions: A Comprehensive Review
di: Emadeldin M. Kamel, et al.
Pubblicazione: (2026)

Design, Synthesis and Pro‐Inflammatory Activity of Palmitoylated Derivatives of Thioglycolic Acid as New Immunomodulators
di: Samia M. Mohamed, et al.
Pubblicazione: (2024)

Small Molecule Inhibitors Targeting Cdc2‐Like Kinase 4: Advances, Challenges, and Opportunities
di: Yu Jiang, et al.
Pubblicazione: (2025)

Biochemical and Structural Studies of Protein Tyrosine Phosphatase PTP‐PEST (PTPN12) in Search of Small Molecule Inhibitors
di: Delna Johnson, et al.
Pubblicazione: (2025)

Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide
di: Isabella R. Palombi, et al.
Pubblicazione: (2025)

Design of Hybrid Bioactive Peptides Derived From Cecropin and Cathepsin for Therapeutic Application
di: Gabriele Santos Cepinho, et al.
Pubblicazione: (2025)

Anti‐Proliferative and Apoptotic Evaluation of a Novel Synthesized Acridine Hybrid With Anticipated Synergistic Effect to Paclitaxel on Breast Cancer Cells
di: Esraa A. Aidy, et al.
Pubblicazione: (2026)

Structural Insights Into Papain‐Derived Synthetic Antibacterial Peptides for Targeting Klebsiella pneumoniae
di: Marcos Antônio Ferreira, et al.
Pubblicazione: (2025)

Investigating the effect of polymerase inhibitors on cellular proliferation: Computational studies, cytotoxicity, CDK1 inhibitory potential, and LC‐MS/MS cancer cell entrapment assays
di: Faten Farouk, et al.
Pubblicazione: (2024)

In vivo anticancer study of sodium 2‐[(4‐oxidobenzylidene)amino]‐6H‐1,3,4‐thiadiazine‐5‐olate against Ehrlich ascites carcinoma via targeting PI3K/mTOR pathway
di: Youstina William Rizzk, et al.
Pubblicazione: (2024)

99mTc‐HYNIC PEGylated Peptide Probe Targeting HER2‐Expression in Breast Cancer
di: Sushree Arpitabala Yadav, et al.
Pubblicazione: (2025)

Emerging Roles of Osmium Complexes in Cancer Therapy, Their Mechanism of Action, Challenges and Future Perspectives
di: Eman M. Atiyah, et al.
Pubblicazione: (2026)

Emerging Design Principles at the Forefront of Mitochondrial Transplantation Using Engineering Methodologies: Current Achievements and Future Directions
di: Naoto Yoshinaga, et al.
Pubblicazione: (2026)

Artesunate Enhances Sensitivity of Renal Cancer Cells to Sunitnib by Mediating Tripartite Motif Containing 24‐Induced Ubiquitination of Paired Box 6
di: Zelin Cui, et al.
Pubblicazione: (2025)

New Cytotoxic α‐Aminoacylamide and bis‐1,5‐Disubstituted Tetrazole Adducts From Amino‐Diterpene Molecules by Ugi Reaction
di: Anna Smirnova, et al.
Pubblicazione: (2024)

Dexmedetomidine Inhibits Ferroptosis by Regulating the SRY‐Box Transcription Factor 9/Divalent Metal Transporter‐1 Axis to Alleviate Cerebral Ischemia/Reperfusion Injury
di: Zhen Liu, et al.
Pubblicazione: (2025)

Exploring the cytotoxic potential of biflavones of Araucaria cunninghamii: Precise identification combined by LC‐HRMS‐metabolomics and database mining, targeted isolation, network pharmacology, in vitro cytotoxicity, and docking studies
di: Bharat Sahu, et al.
Pubblicazione: (2024)

Plumbagin Triggers STING Pathway Activation to Suppress Non‐Small Cell Lung Cancer Progression
di: Li‐Ping Kang, et al.
Pubblicazione: (2025)

Procyanidin Alleviates Diabetic Retinopathy by Activating the Expression of Activating Transcription Factor 1 Expression to Upregulate Synoviolin 1 and Inhibit the High Mobility Group Box 1/Toll‐Like Receptor 4 Pathway
di: Limin Zheng, et al.
Pubblicazione: (2025)

Integrative Experimental Paradigm of Oxadiazole–Schiff Base Hybrids: Pharmacophore‐Driven Docking Simulations and DFT Insights Toward Antidiabetic Therapeutic Discovery
di: Aisha Bibi, et al.
Pubblicazione: (2026)

Molecular Mechanisms and Efficacy of Tislelizumab, a PD ‐1 Inhibitor Developed in China, in Non‐Small Cell Lung Cancer
di: Yihao Liu, et al.
Pubblicazione: (2026)

Rutecarpine Suppresses Non‐Small Cell Lung Cancer Progression Through Activating the STING Pathway and Elevating CD8+ T Cells
di: Ze‐Bo Jiang, et al.
Pubblicazione: (2025)

Exploring the Effect of Gomisin A on Non‐Small Cell Lung Cancer With Network Pharmacology, Molecular Docking, In Vitro and In Vivo Assays
di: Mei Liu, et al.
Pubblicazione: (2024)

Melatonin and its bioisosteres as potential therapeutic agents for the treatment of retinopathy of prematurity
di: N. A. Osipova, et al.
Pubblicazione: (2024)

Assessment of Antidiarrheal Activity of Fraxin in Chick: Synergistic Effects and Molecular Docking Study
di: Wahidul Alam, et al.
Pubblicazione: (2026)

Curculigoside Induces Ferroptosis in Non‐Small Cell Lung Cancer Cells Through a Mechanism Involving Wilms' Tumor 1‐Associating Protein‐Mediated m6A Modification of GTP Cyclohydrolase 1
di: Lizheng Lv, et al.
Pubblicazione: (2026)

Coumarin‐Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents
di: Islam K. Matar, et al.
Pubblicazione: (2026)

Beyond ATP Synthase Inhibition: Chemical Diversification, Bioactivities, and Therapeutic Potential of Oligomycin A
di: Mohamed S. Nafie, et al.
Pubblicazione: (2025)

Synthesis and Molecular Modeling Studies of New Thiadiazole‐Thiophene Compounds as Potent Antimicrobial Agents
di: Nuha M. Halawani, et al.
Pubblicazione: (2025)

Directed Design, Screening and Antiglycation Activity for 3‐Substituted Thiazolium Derivatives, New Analogs of Alagebrium
di: Olga N. Zhukovskaya, et al.
Pubblicazione: (2024)

Spacered With Tetrazole Oleanolic and Ursolic Indolo‐Acids Are Strong Inhibitors of α‐Glucosidase
di: Anastasiya V. Petrova, et al.
Pubblicazione: (2025)

New Benzothiazole‐Thiadiazole‐Based Ketones as Potential Antiviral and Anticancer Agents: Synthesis, DFT, and Molecular Docking Studies
di: Khadra B. Alomari, et al.
Pubblicazione: (2025)

Synthesis of New Thiazole‐Pyrazole Analogues: Molecular Modelling, Antiproliferative/Antiviral Activities, and ADME Studies
di: Hind A. Siddiq, et al.
Pubblicazione: (2025)

Attempts to Achieve Targeted Covalent Inhibition of Hsp90 β
di: Terin D'Amico, et al.
Pubblicazione: (2026)

N‐Substituted‐5‐ [(2,5‐Dihydroxybenzyl)amino]salicylamides as Lavendustin Analogs: Antiproliferative Activity, COMPARE Analyses, Mechanistic, Docking, ADMET and Toxicity Studies
di: Hajjaj H. M. Abdu‐Allah, et al.
Pubblicazione: (2025)

Novel Triazole‐Linked Indole Derivatives as Potent Soluble Epoxy Hydrolase Inhibitors With Promising Anticancer Activity
di: Vijaykumar D. Nimbarte, et al.
Pubblicazione: (2025)

Tyramine Derivatives as Versatile Pharmacophores With Potent Biological Properties: Sex Hormone–Binding Globulin Inhibition, Colon Cancer Antimigration, and Antimicrobial Activity
di: Jovana S. Marjanović, et al.
Pubblicazione: (2024)

Inhibitory Mechanisms of β ‐Glucuronidase by Hibiscus syriacus Phenolics: Integrating Computational and Experimental Approaches
di: Haifa A. Alqhtani, et al.
Pubblicazione: (2025)