| _version_ | 1867010963670040576 |
|---|---|
| author | Liwen Chen Hui Zhang Chao Shang Yang Hong |
| author_facet | Liwen Chen Hui Zhang Chao Shang Yang Hong Liwen Chen Hui Zhang Chao Shang Yang Hong |
| collection | Wiley Open Access |
| contents | The Role and Applied Value of Mitochondria in Glioma‐Related Research Liwen Chen Hui Zhang Chao Shang Yang Hong CNS Neuroscience & Therapeutics ABSTRACTMitochondria, known as the “energy factory” of cells, are essential organelles with a double membrane structure and genetic material found in most eukaryotic cells. They play a crucial role in tumorigenesis and development, with alterations in mitochondrial structure and function in tumor cells leading to characteristics such as rapid proliferation, invasion, and drug resistance. Glioma, the most common brain tumor with a high recurrence rate and limited treatment options, has been linked to changes in mitochondrial structure and function. This review focuses on the bioenergetics, dynamics, metastasis, and autophagy of mitochondria in relation to glioma proliferation, as well as the potential use of mitochondria‐targeting drugs in glioma treatment. 10.1111/cns.70121 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/cns.70121 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cns_70121 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | The Role and Applied Value of Mitochondria in Glioma‐Related Research Liwen Chen Hui Zhang Chao Shang Yang Hong CNS Neuroscience & Therapeutics The Role and Applied Value of Mitochondria in Glioma‐Related Research Liwen Chen Hui Zhang Chao Shang Yang Hong CNS Neuroscience & Therapeutics ABSTRACTMitochondria, known as the “energy factory” of cells, are essential organelles with a double membrane structure and genetic material found in most eukaryotic cells. They play a crucial role in tumorigenesis and development, with alterations in mitochondrial structure and function in tumor cells leading to characteristics such as rapid proliferation, invasion, and drug resistance. Glioma, the most common brain tumor with a high recurrence rate and limited treatment options, has been linked to changes in mitochondrial structure and function. This review focuses on the bioenergetics, dynamics, metastasis, and autophagy of mitochondria in relation to glioma proliferation, as well as the potential use of mitochondria‐targeting drugs in glioma treatment. 10.1111/cns.70121 http://creativecommons.org/licenses/by/4.0/ |
| title | The Role and Applied Value of Mitochondria in Glioma‐Related Research |
| topic | CNS Neuroscience & Therapeutics |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cns.70121 |