Immunohistochemical differentiation of keratins and involucrin between palmar psoriasis, chronic hand eczema and hyperkeratotic hand eczema
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| Format: | Artículo Open Access |
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2024
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| _version_ | 1867019011151101952 |
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| author | Eun Joo Baek Da Yeon Jung Na Reu Seung Ye Ji Jang Eun Joo Park Kwang Ho Kim |
| author_facet | Eun Joo Baek Da Yeon Jung Na Reu Seung Ye Ji Jang Eun Joo Park Kwang Ho Kim Eun Joo Baek Da Yeon Jung Na Reu Seung Ye Ji Jang Eun Joo Park Kwang Ho Kim |
| collection | Wiley Open Access |
| contents | Immunohistochemical differentiation of keratins and involucrin between palmar psoriasis, chronic hand eczema and hyperkeratotic hand eczema Eun Joo Baek Da Yeon Jung Na Reu Seung Ye Ji Jang Eun Joo Park Kwang Ho Kim Contact Dermatitis AbstractBackgroundCommon hyperkeratotic palmar skin lesions include chronic hand eczema (CHE), hyperkeratotic hand eczema (HHE), palmar psoriasis (PP). However, clinically differentiating these disorders is often challenging.ObjectivesTo compare the expressions of keratin (K) 5, K9, K14 and involucrin in palmar hyperkeratotic lesions (HHE, CHE and PP).Materials and MethodsImmunohistochemical staining was performed on skin biopsy specimens obtained from the palms of patients clinically diagnosed with CHE, HHE and PP (n = 21, 24 and 18, respectively).ResultsK5 and K14 expression levels were higher in the spinous and granular layers of PP and HHE compared to CHE. Involucrin was expressed in the basal layer of PP and HHE but not in CHE. K9 expression was decreased in PP and HHE compared to CHE.ConclusionKeratin and involucrin expression in the epidermis are markers of keratinocyte differentiation. Expression levels of keratin and involucrin were similar between the HHE and PP groups, suggesting that HHE shares pathogenesis with PP rather than CHE. 10.1111/cod.14499 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/cod.14499 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cod_14499 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Immunohistochemical differentiation of keratins and involucrin between palmar psoriasis, chronic hand eczema and hyperkeratotic hand eczema Eun Joo Baek Da Yeon Jung Na Reu Seung Ye Ji Jang Eun Joo Park Kwang Ho Kim Contact Dermatitis Immunohistochemical differentiation of keratins and involucrin between palmar psoriasis, chronic hand eczema and hyperkeratotic hand eczema Eun Joo Baek Da Yeon Jung Na Reu Seung Ye Ji Jang Eun Joo Park Kwang Ho Kim Contact Dermatitis AbstractBackgroundCommon hyperkeratotic palmar skin lesions include chronic hand eczema (CHE), hyperkeratotic hand eczema (HHE), palmar psoriasis (PP). However, clinically differentiating these disorders is often challenging.ObjectivesTo compare the expressions of keratin (K) 5, K9, K14 and involucrin in palmar hyperkeratotic lesions (HHE, CHE and PP).Materials and MethodsImmunohistochemical staining was performed on skin biopsy specimens obtained from the palms of patients clinically diagnosed with CHE, HHE and PP (n = 21, 24 and 18, respectively).ResultsK5 and K14 expression levels were higher in the spinous and granular layers of PP and HHE compared to CHE. Involucrin was expressed in the basal layer of PP and HHE but not in CHE. K9 expression was decreased in PP and HHE compared to CHE.ConclusionKeratin and involucrin expression in the epidermis are markers of keratinocyte differentiation. Expression levels of keratin and involucrin were similar between the HHE and PP groups, suggesting that HHE shares pathogenesis with PP rather than CHE. 10.1111/cod.14499 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Immunohistochemical differentiation of keratins and involucrin between palmar psoriasis, chronic hand eczema and hyperkeratotic hand eczema |
| topic | Contact Dermatitis |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cod.14499 |