2‐Hydroxyethyl methacrylate (2‐HEMA) sensitization, a global epidemic at its peak in Spain?
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Wiley
2024
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| author | Maria Elena Gatica‐Ortega Maria Antonia Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Tatiana Sanz‐Sánchez José Manuel Carrascosa‐Carrillo Susana Córdoba‐Guijarro Javier Sánchez‐Pérez Juan Francisco Silvestre Francisco Javier Ortiz‐de Frutos Fátima Tous‐Romero Virginia Fernández‐Redondo Esther Serra‐Baldrich Inmaculada Ruíz‐González Ricardo González Pérez Javier Miquel‐Miquel Paloma Sánchez‐Pedreño Guillén Marcos Hervella‐García Felipe Heras‐Mendaza Enrique Gómez‐de‐la‐Fuente Violeta Zaragoza‐Ninet Araceli Sánchez Gilo Mercedes Rodríguez‐Serna Gemma Melé‐Ninot Miguel Ángel Descalzo Marina de‐Vega Ignacio García‐Doval Leopoldo Borrego |
| author_facet | Maria Elena Gatica‐Ortega Maria Antonia Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Tatiana Sanz‐Sánchez José Manuel Carrascosa‐Carrillo Susana Córdoba‐Guijarro Javier Sánchez‐Pérez Juan Francisco Silvestre Francisco Javier Ortiz‐de Frutos Fátima Tous‐Romero Virginia Fernández‐Redondo Esther Serra‐Baldrich Inmaculada Ruíz‐González Ricardo González Pérez Javier Miquel‐Miquel Paloma Sánchez‐Pedreño Guillén Marcos Hervella‐García Felipe Heras‐Mendaza Enrique Gómez‐de‐la‐Fuente Violeta Zaragoza‐Ninet Araceli Sánchez Gilo Mercedes Rodríguez‐Serna Gemma Melé‐Ninot Miguel Ángel Descalzo Marina de‐Vega Ignacio García‐Doval Leopoldo Borrego Maria Elena Gatica‐Ortega Maria Antonia Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Tatiana Sanz‐Sánchez José Manuel Carrascosa‐Carrillo Susana Córdoba‐Guijarro Javier Sánchez‐Pérez Juan Francisco Silvestre Francisco Javier Ortiz‐de Frutos Fátima Tous‐Romero Virginia Fernández‐Redondo Esther Serra‐Baldrich Inmaculada Ruíz‐González Ricardo González Pérez Javier Miquel‐Miquel Paloma Sánchez‐Pedreño Guillén Marcos Hervella‐García Felipe Heras‐Mendaza Enrique Gómez‐de‐la‐Fuente Violeta Zaragoza‐Ninet Araceli Sánchez Gilo Mercedes Rodríguez‐Serna Gemma Melé‐Ninot Miguel Ángel Descalzo Marina de‐Vega Ignacio García‐Doval Leopoldo Borrego |
| collection | Wiley Open Access |
| contents | 2‐Hydroxyethyl methacrylate (2‐HEMA) sensitization, a global epidemic at its peak in Spain? Maria Elena Gatica‐Ortega Maria Antonia Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Tatiana Sanz‐Sánchez José Manuel Carrascosa‐Carrillo Susana Córdoba‐Guijarro Javier Sánchez‐Pérez Juan Francisco Silvestre Francisco Javier Ortiz‐de Frutos Fátima Tous‐Romero Virginia Fernández‐Redondo Esther Serra‐Baldrich Inmaculada Ruíz‐González Ricardo González Pérez Javier Miquel‐Miquel Paloma Sánchez‐Pedreño Guillén Marcos Hervella‐García Felipe Heras‐Mendaza Enrique Gómez‐de‐la‐Fuente Violeta Zaragoza‐Ninet Araceli Sánchez Gilo Mercedes Rodríguez‐Serna Gemma Melé‐Ninot Miguel Ángel Descalzo Marina de‐Vega Ignacio García‐Doval Leopoldo Borrego Contact Dermatitis AbstractBackgroundA global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products.ObjectivesTo evaluate the frequency of sensitization to 2‐hydroxyethyl methacrylate (2‐HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates.MethodsFrom January 2019 to December 2022, 2‐HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres.ResultsSix thousand one hundred thirty‐four patients were consecutively patch tested with 2‐HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable ‘occupational’ was found to be significantly associated with a higher risk for relevant positive reactions to 2‐HEMA (OR: 10.9; 95% CI: 8.1–14.9).Conclusion(Meth)acrylate sensitization is a prevalent health issue in Spain. 2‐HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means. 10.1111/cod.14520 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/cod.14520 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cod_14520 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | 2‐Hydroxyethyl methacrylate (2‐HEMA) sensitization, a global epidemic at its peak in Spain? Maria Elena Gatica‐Ortega Maria Antonia Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Tatiana Sanz‐Sánchez José Manuel Carrascosa‐Carrillo Susana Córdoba‐Guijarro Javier Sánchez‐Pérez Juan Francisco Silvestre Francisco Javier Ortiz‐de Frutos Fátima Tous‐Romero Virginia Fernández‐Redondo Esther Serra‐Baldrich Inmaculada Ruíz‐González Ricardo González Pérez Javier Miquel‐Miquel Paloma Sánchez‐Pedreño Guillén Marcos Hervella‐García Felipe Heras‐Mendaza Enrique Gómez‐de‐la‐Fuente Violeta Zaragoza‐Ninet Araceli Sánchez Gilo Mercedes Rodríguez‐Serna Gemma Melé‐Ninot Miguel Ángel Descalzo Marina de‐Vega Ignacio García‐Doval Leopoldo Borrego Contact Dermatitis 2‐Hydroxyethyl methacrylate (2‐HEMA) sensitization, a global epidemic at its peak in Spain? Maria Elena Gatica‐Ortega Maria Antonia Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Tatiana Sanz‐Sánchez José Manuel Carrascosa‐Carrillo Susana Córdoba‐Guijarro Javier Sánchez‐Pérez Juan Francisco Silvestre Francisco Javier Ortiz‐de Frutos Fátima Tous‐Romero Virginia Fernández‐Redondo Esther Serra‐Baldrich Inmaculada Ruíz‐González Ricardo González Pérez Javier Miquel‐Miquel Paloma Sánchez‐Pedreño Guillén Marcos Hervella‐García Felipe Heras‐Mendaza Enrique Gómez‐de‐la‐Fuente Violeta Zaragoza‐Ninet Araceli Sánchez Gilo Mercedes Rodríguez‐Serna Gemma Melé‐Ninot Miguel Ángel Descalzo Marina de‐Vega Ignacio García‐Doval Leopoldo Borrego Contact Dermatitis AbstractBackgroundA global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products.ObjectivesTo evaluate the frequency of sensitization to 2‐hydroxyethyl methacrylate (2‐HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates.MethodsFrom January 2019 to December 2022, 2‐HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres.ResultsSix thousand one hundred thirty‐four patients were consecutively patch tested with 2‐HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable ‘occupational’ was found to be significantly associated with a higher risk for relevant positive reactions to 2‐HEMA (OR: 10.9; 95% CI: 8.1–14.9).Conclusion(Meth)acrylate sensitization is a prevalent health issue in Spain. 2‐HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means. 10.1111/cod.14520 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | 2‐Hydroxyethyl methacrylate (2‐HEMA) sensitization, a global epidemic at its peak in Spain? |
| topic | Contact Dermatitis |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cod.14520 |