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Main Authors:	Fieke M. Rosenberg, Peter J. van der Most, Laura Loman, Zoha Kamali, Daan Dittmar, Harold Snieder, Marie L. A. Schuttelaar
Format:	Artículo Open Access
Published:	Wiley 2024
Subjects:	Contact Dermatitis
Online Access:	https://onlinelibrary.wiley.com/doi/10.1111/cod.14619
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author	Fieke M. Rosenberg Peter J. van der Most Laura Loman Zoha Kamali Daan Dittmar Harold Snieder Marie L. A. Schuttelaar
author_facet	Fieke M. Rosenberg Peter J. van der Most Laura Loman Zoha Kamali Daan Dittmar Harold Snieder Marie L. A. Schuttelaar Fieke M. Rosenberg Peter J. van der Most Laura Loman Zoha Kamali Daan Dittmar Harold Snieder Marie L. A. Schuttelaar
collection	Wiley Open Access
contents	A genome‐wide association study of hand eczema identifies locus 20q13.33 and reveals genetic overlap with atopic dermatitis Fieke M. Rosenberg Peter J. van der Most Laura Loman Zoha Kamali Daan Dittmar Harold Snieder Marie L. A. Schuttelaar Contact Dermatitis AbstractBackgroundTwin studies revealed that genetic effects play a role in hand eczema (HE), but the responsible genetic factors are unknown.ObjectivesTo identify and characterise genetic loci associated with HE and to provide insight into the genetic overlap between HE and atopic dermatitis (AD).MethodsWe used questionnaire‐derived and genotype data from the European population‐based Lifelines cohort and biobank. We performed a discovery genome‐wide association study (GWAS) of HE (2879 cases and 16 249 controls) and of AD (1706 cases and 17 190 controls). We replicated our findings in an independent Lifelines sample for HE (1188 cases and 6431 controls) and AD (757 cases and 6747 controls). We conducted several post‐GWAS analyses and performed genetic correlation analyses between our HE results and independent AD data.ResultsThe two‐step GWAS of HE, regardless of adjusting for AD, identified one independent locus 20q13.33, likely driven by a number of causal single‐nucleotide polymorphisms. For the AD GWAS, we replicated a known stop‐gained rs61816761 at locus 1q21.3 (FLG, FLGAS1). We found a strong genetic correlation (p < 0.01) between HE and AD (rg = 0.65), regardless of adjusting for AD (rg = 0.63).ConclusionsLocus 20q13.33 is associated with HE, and there is a large genetic overlap between HE and AD. 10.1111/cod.14619 http://creativecommons.org/licenses/by-nc-nd/4.0/
doi_str_mv	10.1111/cod.14619
format	Artículo Open Access
id	wiley_oa_10_1111_cod_14619
institution	Wiley Open Access
license_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
publishDate	2024
publisher	Wiley
record_format	wiley_oa
spellingShingle	A genome‐wide association study of hand eczema identifies locus 20q13.33 and reveals genetic overlap with atopic dermatitis Fieke M. Rosenberg Peter J. van der Most Laura Loman Zoha Kamali Daan Dittmar Harold Snieder Marie L. A. Schuttelaar Contact Dermatitis A genome‐wide association study of hand eczema identifies locus 20q13.33 and reveals genetic overlap with atopic dermatitis Fieke M. Rosenberg Peter J. van der Most Laura Loman Zoha Kamali Daan Dittmar Harold Snieder Marie L. A. Schuttelaar Contact Dermatitis AbstractBackgroundTwin studies revealed that genetic effects play a role in hand eczema (HE), but the responsible genetic factors are unknown.ObjectivesTo identify and characterise genetic loci associated with HE and to provide insight into the genetic overlap between HE and atopic dermatitis (AD).MethodsWe used questionnaire‐derived and genotype data from the European population‐based Lifelines cohort and biobank. We performed a discovery genome‐wide association study (GWAS) of HE (2879 cases and 16 249 controls) and of AD (1706 cases and 17 190 controls). We replicated our findings in an independent Lifelines sample for HE (1188 cases and 6431 controls) and AD (757 cases and 6747 controls). We conducted several post‐GWAS analyses and performed genetic correlation analyses between our HE results and independent AD data.ResultsThe two‐step GWAS of HE, regardless of adjusting for AD, identified one independent locus 20q13.33, likely driven by a number of causal single‐nucleotide polymorphisms. For the AD GWAS, we replicated a known stop‐gained rs61816761 at locus 1q21.3 (FLG, FLGAS1). We found a strong genetic correlation (p < 0.01) between HE and AD (rg = 0.65), regardless of adjusting for AD (rg = 0.63).ConclusionsLocus 20q13.33 is associated with HE, and there is a large genetic overlap between HE and AD. 10.1111/cod.14619 http://creativecommons.org/licenses/by-nc-nd/4.0/
title	A genome‐wide association study of hand eczema identifies locus 20q13.33 and reveals genetic overlap with atopic dermatitis
topic	Contact Dermatitis
url	https://onlinelibrary.wiley.com/doi/10.1111/cod.14619

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