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| Formato: | Artículo Open Access |
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Wiley
2024
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| Acceso en línea: | https://onlinelibrary.wiley.com/doi/10.1111/cod.14641 |
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| author | Jakob F. B. Schwensen Wolfgang Uter Olivier Aerts Tove Agner Richard Brans Magnus Bruze Caterina Foti Ana Maria Giménez‐Arnau Margarida Gonçalo Cecilia Svedman Luca Stingeni Mark Wilkinson Jeanne Duus Johansen |
| author_facet | Jakob F. B. Schwensen Wolfgang Uter Olivier Aerts Tove Agner Richard Brans Magnus Bruze Caterina Foti Ana Maria Giménez‐Arnau Margarida Gonçalo Cecilia Svedman Luca Stingeni Mark Wilkinson Jeanne Duus Johansen Jakob F. B. Schwensen Wolfgang Uter Olivier Aerts Tove Agner Richard Brans Magnus Bruze Caterina Foti Ana Maria Giménez‐Arnau Margarida Gonçalo Cecilia Svedman Luca Stingeni Mark Wilkinson Jeanne Duus Johansen |
| collection | Wiley Open Access |
| contents | Current frequency of contact allergy to isothiazolinones (methyl‐, benz‐ and octylisothiazolinone) across Europe Jakob F. B. Schwensen Wolfgang Uter Olivier Aerts Tove Agner Richard Brans Magnus Bruze Caterina Foti Ana Maria Giménez‐Arnau Margarida Gonçalo Cecilia Svedman Luca Stingeni Mark Wilkinson Jeanne Duus Johansen Contact Dermatitis AbstractBackgroundThe use of methylisothiazolinone (MI) as a preservative in cosmetic products caused an alarming increase in MI contact allergy across Europe in the 2010s. This was followed by regulations of use with a total ban on leave‐on (implemented in 2017) and reduced use concentrations in rinse‐off cosmetics (2018).ObjectiveTo follow‐up on the prevalence of contact allergy to MI and the related benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in consecutively patch‐tested patients in Europe.MethodsA cross‐sectional audit following the design of two previous audits on MI contact allergy from 1 May 2022 to 31 October 2022 included all patients patch tested with the European baseline series, including or supplemented with MI, BIT and OIT across 10 departments in eight European countries.ResultsA total of 2554 patients were consecutively patch tested with the three isothiazolinones during the study period. The prevalence of MI and BIT contact allergy was 2.9% (95% confidence interval [CI]: 2.3%–3.7%; range 1.1%–5.8%) and 3.1% (95% CI: 2.4%–3.9%; range 0.0%–6.6%), respectively; that of OIT was 0.7% (95% CI: 0.4%–1.1%; range 0%–3.2%). Rinse‐off cosmetic (73.3%) and leave‐on cosmetic products (13.3%) were still associated with eliciting allergic contact dermatitis to MI.ConclusionWe confirmed a positive impact of regulatory measures on the prevalence of MI contact allergy in Europe, which halved compared to 2015. However, our data suggest that consumers may still be exposed to older cosmetic products containing MI. BIT has superseded MI in causing contact allergy, despite not being allowed for use in cosmetic products. 10.1111/cod.14641 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/cod.14641 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cod_14641 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Current frequency of contact allergy to isothiazolinones (methyl‐, benz‐ and octylisothiazolinone) across Europe Jakob F. B. Schwensen Wolfgang Uter Olivier Aerts Tove Agner Richard Brans Magnus Bruze Caterina Foti Ana Maria Giménez‐Arnau Margarida Gonçalo Cecilia Svedman Luca Stingeni Mark Wilkinson Jeanne Duus Johansen Contact Dermatitis Current frequency of contact allergy to isothiazolinones (methyl‐, benz‐ and octylisothiazolinone) across Europe Jakob F. B. Schwensen Wolfgang Uter Olivier Aerts Tove Agner Richard Brans Magnus Bruze Caterina Foti Ana Maria Giménez‐Arnau Margarida Gonçalo Cecilia Svedman Luca Stingeni Mark Wilkinson Jeanne Duus Johansen Contact Dermatitis AbstractBackgroundThe use of methylisothiazolinone (MI) as a preservative in cosmetic products caused an alarming increase in MI contact allergy across Europe in the 2010s. This was followed by regulations of use with a total ban on leave‐on (implemented in 2017) and reduced use concentrations in rinse‐off cosmetics (2018).ObjectiveTo follow‐up on the prevalence of contact allergy to MI and the related benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in consecutively patch‐tested patients in Europe.MethodsA cross‐sectional audit following the design of two previous audits on MI contact allergy from 1 May 2022 to 31 October 2022 included all patients patch tested with the European baseline series, including or supplemented with MI, BIT and OIT across 10 departments in eight European countries.ResultsA total of 2554 patients were consecutively patch tested with the three isothiazolinones during the study period. The prevalence of MI and BIT contact allergy was 2.9% (95% confidence interval [CI]: 2.3%–3.7%; range 1.1%–5.8%) and 3.1% (95% CI: 2.4%–3.9%; range 0.0%–6.6%), respectively; that of OIT was 0.7% (95% CI: 0.4%–1.1%; range 0%–3.2%). Rinse‐off cosmetic (73.3%) and leave‐on cosmetic products (13.3%) were still associated with eliciting allergic contact dermatitis to MI.ConclusionWe confirmed a positive impact of regulatory measures on the prevalence of MI contact allergy in Europe, which halved compared to 2015. However, our data suggest that consumers may still be exposed to older cosmetic products containing MI. BIT has superseded MI in causing contact allergy, despite not being allowed for use in cosmetic products. 10.1111/cod.14641 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Current frequency of contact allergy to isothiazolinones (methyl‐, benz‐ and octylisothiazolinone) across Europe |
| topic | Contact Dermatitis |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cod.14641 |