An emerging epidemic of allergic contact dermatitis due to phytonadione epoxide (oxidised vitamin K1)
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2024
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| author | María E. Gatica‐Ortega María A. Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Esther Serra‐Baldrich Violeta Zaragoza‐Ninet Tatiana Sanz‐Sánchez Araceli Sánchez‐Gilo David Pesqué Fátima Tous‐Romero Francisco Javier Ortiz‐de‐Frutos Eduardo de la Rosa‐Fernández Sara Dorta‐Alom Marta Elosua‐González Ricardo González‐Pérez José Manuel Carrascosa‐Carrillo Mónica Munera‐Campos Juan Francisco Silvestre‐Salvador Javier Miquel‐Miquel Antonio de Mateo Minguez Leopoldo Borrego |
| author_facet | María E. Gatica‐Ortega María A. Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Esther Serra‐Baldrich Violeta Zaragoza‐Ninet Tatiana Sanz‐Sánchez Araceli Sánchez‐Gilo David Pesqué Fátima Tous‐Romero Francisco Javier Ortiz‐de‐Frutos Eduardo de la Rosa‐Fernández Sara Dorta‐Alom Marta Elosua‐González Ricardo González‐Pérez José Manuel Carrascosa‐Carrillo Mónica Munera‐Campos Juan Francisco Silvestre‐Salvador Javier Miquel‐Miquel Antonio de Mateo Minguez Leopoldo Borrego María E. Gatica‐Ortega María A. Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Esther Serra‐Baldrich Violeta Zaragoza‐Ninet Tatiana Sanz‐Sánchez Araceli Sánchez‐Gilo David Pesqué Fátima Tous‐Romero Francisco Javier Ortiz‐de‐Frutos Eduardo de la Rosa‐Fernández Sara Dorta‐Alom Marta Elosua‐González Ricardo González‐Pérez José Manuel Carrascosa‐Carrillo Mónica Munera‐Campos Juan Francisco Silvestre‐Salvador Javier Miquel‐Miquel Antonio de Mateo Minguez Leopoldo Borrego |
| collection | Wiley Open Access |
| contents | An emerging epidemic of allergic contact dermatitis due to phytonadione epoxide (oxidised vitamin K1) María E. Gatica‐Ortega María A. Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Esther Serra‐Baldrich Violeta Zaragoza‐Ninet Tatiana Sanz‐Sánchez Araceli Sánchez‐Gilo David Pesqué Fátima Tous‐Romero Francisco Javier Ortiz‐de‐Frutos Eduardo de la Rosa‐Fernández Sara Dorta‐Alom Marta Elosua‐González Ricardo González‐Pérez José Manuel Carrascosa‐Carrillo Mónica Munera‐Campos Juan Francisco Silvestre‐Salvador Javier Miquel‐Miquel Antonio de Mateo Minguez Leopoldo Borrego Contact Dermatitis AbstractBackgroundReports of allergic contact dermatitis (ACD) to phytonadione epoxide (PE) in cosmetics suggest that PE is as powerful a sensitiser as its parent compound phytonadione.ObjectiveTo evaluate a case series of ACD to PE in Spain.MethodsWe reviewed the records of 20 patients with ACD to cosmetics containing PE diagnosed across Spain between January 2019 and June 2023.ResultsAll 20 patients developed patch test (PT) or repeated open application test (ROAT) reactions to cosmetics containing PE. All involved women with eyelid eczema. PT or ROAT with PE preparations were positive in 17/20 (85%). PE at 1%, 5%, 10% and 20% in pet. was patch‐tested in 8/17, 14/17, 11/17 and 8/17 patients; being positive in 6/8 (75%), 13/14 (92.85%), 11/11 (100%) and 8/8 (100%), respectively.ConclusionRegulators should, not only ban the specific dangerous cosmetic ingredients, but also consider to ban or keep under close surveillance those closely related products or derivatives that might potentially cause similar harmful effects. PTs with PE are suggested to be performed at a 5% concentration in pet. Higher concentrations (10% pet.) should be tested whenever PTs with 5% pet. PE are negative. 10.1111/cod.14675 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/cod.14675 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cod_14675 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | An emerging epidemic of allergic contact dermatitis due to phytonadione epoxide (oxidised vitamin K1) María E. Gatica‐Ortega María A. Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Esther Serra‐Baldrich Violeta Zaragoza‐Ninet Tatiana Sanz‐Sánchez Araceli Sánchez‐Gilo David Pesqué Fátima Tous‐Romero Francisco Javier Ortiz‐de‐Frutos Eduardo de la Rosa‐Fernández Sara Dorta‐Alom Marta Elosua‐González Ricardo González‐Pérez José Manuel Carrascosa‐Carrillo Mónica Munera‐Campos Juan Francisco Silvestre‐Salvador Javier Miquel‐Miquel Antonio de Mateo Minguez Leopoldo Borrego Contact Dermatitis An emerging epidemic of allergic contact dermatitis due to phytonadione epoxide (oxidised vitamin K1) María E. Gatica‐Ortega María A. Pastor‐Nieto Ana María Giménez‐Arnau Pedro Mercader‐García Esther Serra‐Baldrich Violeta Zaragoza‐Ninet Tatiana Sanz‐Sánchez Araceli Sánchez‐Gilo David Pesqué Fátima Tous‐Romero Francisco Javier Ortiz‐de‐Frutos Eduardo de la Rosa‐Fernández Sara Dorta‐Alom Marta Elosua‐González Ricardo González‐Pérez José Manuel Carrascosa‐Carrillo Mónica Munera‐Campos Juan Francisco Silvestre‐Salvador Javier Miquel‐Miquel Antonio de Mateo Minguez Leopoldo Borrego Contact Dermatitis AbstractBackgroundReports of allergic contact dermatitis (ACD) to phytonadione epoxide (PE) in cosmetics suggest that PE is as powerful a sensitiser as its parent compound phytonadione.ObjectiveTo evaluate a case series of ACD to PE in Spain.MethodsWe reviewed the records of 20 patients with ACD to cosmetics containing PE diagnosed across Spain between January 2019 and June 2023.ResultsAll 20 patients developed patch test (PT) or repeated open application test (ROAT) reactions to cosmetics containing PE. All involved women with eyelid eczema. PT or ROAT with PE preparations were positive in 17/20 (85%). PE at 1%, 5%, 10% and 20% in pet. was patch‐tested in 8/17, 14/17, 11/17 and 8/17 patients; being positive in 6/8 (75%), 13/14 (92.85%), 11/11 (100%) and 8/8 (100%), respectively.ConclusionRegulators should, not only ban the specific dangerous cosmetic ingredients, but also consider to ban or keep under close surveillance those closely related products or derivatives that might potentially cause similar harmful effects. PTs with PE are suggested to be performed at a 5% concentration in pet. Higher concentrations (10% pet.) should be tested whenever PTs with 5% pet. PE are negative. 10.1111/cod.14675 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | An emerging epidemic of allergic contact dermatitis due to phytonadione epoxide (oxidised vitamin K1) |
| topic | Contact Dermatitis |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cod.14675 |