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| Main Authors: | , , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2024
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| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/cod.14699 |
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| _version_ | 1867019120581541888 |
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| author | Yasemin Topal Yüksel Henrik Thoning Lotte Seiding Larsen Lucine Lehmann Rob Arbuckle Laura Grant Tove Agner |
| author_facet | Yasemin Topal Yüksel Henrik Thoning Lotte Seiding Larsen Lucine Lehmann Rob Arbuckle Laura Grant Tove Agner Yasemin Topal Yüksel Henrik Thoning Lotte Seiding Larsen Lucine Lehmann Rob Arbuckle Laura Grant Tove Agner |
| collection | Wiley Open Access |
| contents | Evaluation of validity, reliability and ability to detect change for the Hand Eczema Severity Index ( HECSI ) and evaluation of HECSI ‐75 and HECSI ‐90 as within‐patient responder definitions Yasemin Topal Yüksel Henrik Thoning Lotte Seiding Larsen Lucine Lehmann Rob Arbuckle Laura Grant Tove Agner Contact Dermatitis Abstract Background The Hand Eczema Severity Index (HECSI) is a Clinician‐Reported Outcome measure of the severity of hand eczema (HE). Objectives This study aimed to evaluate the validity, reliability and ability to detect change of the HECSI, and the HECSI‐75 and HECSI‐90 as responder definitions. Methods Analyses were performed using data from a sample of n = 258 patients with Chronic Hand Eczema (CHE) from a Phase 2b, randomised, double‐blind, vehicle‐controlled trial of delgocitinib cream, pooled across treatment groups. The measurement properties of the HECSI were assessed and the adequacy of the HECSI‐75 and HECSI‐90 as responder definitions was explored through cross‐tabulation. Results Inter‐item correlations provided support for the scoring, whereby items are grouped by areas of the hand. HECSI demonstrated good test–retest reliability with intra‐class correlations >0.70. Construct validity was supported by a logical pattern of correlations with concurrent measures and significant differences in HECSI scores across severity groups ( p < 0.001). HECSI was responsive with statistically significant improvements over time and with significant differences ( p < 0.001) between improved and stable groups. Data provided support for both HECSI‐75 and HECSI‐90 as within‐patient responder definitions. Conclusions HECSI has strong validity, reliability and ability to detect change as a measure of CHE severity. HECSI‐75 and HECSI‐90 are appropriate responder definitions. 10.1111/cod.14699 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/cod.14699 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cod_14699 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Evaluation of validity, reliability and ability to detect change for the Hand Eczema Severity Index ( HECSI ) and evaluation of HECSI ‐75 and HECSI ‐90 as within‐patient responder definitions Yasemin Topal Yüksel Henrik Thoning Lotte Seiding Larsen Lucine Lehmann Rob Arbuckle Laura Grant Tove Agner Contact Dermatitis Evaluation of validity, reliability and ability to detect change for the Hand Eczema Severity Index ( HECSI ) and evaluation of HECSI ‐75 and HECSI ‐90 as within‐patient responder definitions Yasemin Topal Yüksel Henrik Thoning Lotte Seiding Larsen Lucine Lehmann Rob Arbuckle Laura Grant Tove Agner Contact Dermatitis Abstract Background The Hand Eczema Severity Index (HECSI) is a Clinician‐Reported Outcome measure of the severity of hand eczema (HE). Objectives This study aimed to evaluate the validity, reliability and ability to detect change of the HECSI, and the HECSI‐75 and HECSI‐90 as responder definitions. Methods Analyses were performed using data from a sample of n = 258 patients with Chronic Hand Eczema (CHE) from a Phase 2b, randomised, double‐blind, vehicle‐controlled trial of delgocitinib cream, pooled across treatment groups. The measurement properties of the HECSI were assessed and the adequacy of the HECSI‐75 and HECSI‐90 as responder definitions was explored through cross‐tabulation. Results Inter‐item correlations provided support for the scoring, whereby items are grouped by areas of the hand. HECSI demonstrated good test–retest reliability with intra‐class correlations >0.70. Construct validity was supported by a logical pattern of correlations with concurrent measures and significant differences in HECSI scores across severity groups ( p < 0.001). HECSI was responsive with statistically significant improvements over time and with significant differences ( p < 0.001) between improved and stable groups. Data provided support for both HECSI‐75 and HECSI‐90 as within‐patient responder definitions. Conclusions HECSI has strong validity, reliability and ability to detect change as a measure of CHE severity. HECSI‐75 and HECSI‐90 are appropriate responder definitions. 10.1111/cod.14699 http://creativecommons.org/licenses/by/4.0/ |
| title | Evaluation of validity, reliability and ability to detect change for the Hand Eczema Severity Index ( HECSI ) and evaluation of HECSI ‐75 and HECSI ‐90 as within‐patient responder definitions |
| topic | Contact Dermatitis |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cod.14699 |