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Main Authors:	Emma M. van Oers, Norbertus A. Ipenburg, Anton C. de Groot, Thomas Rustemeyer
Format:	Artículo Open Access
Published:	Wiley 2025
Subjects:	Contact Dermatitis
Online Access:	https://onlinelibrary.wiley.com/doi/10.1111/cod.70002
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author	Emma M. van Oers Norbertus A. Ipenburg Anton C. de Groot Thomas Rustemeyer
author_facet	Emma M. van Oers Norbertus A. Ipenburg Anton C. de Groot Thomas Rustemeyer Emma M. van Oers Norbertus A. Ipenburg Anton C. de Groot Thomas Rustemeyer
collection	Wiley Open Access
contents	Results of Patch Testing With a Brazilian Propolis Dilution Series Emma M. van Oers Norbertus A. Ipenburg Anton C. de Groot Thomas Rustemeyer Contact Dermatitis ABSTRACT Background Patch testing with Brazilian propolis 10% pet. has yielded very high rates of positive reactions (> 20%). For most, no clinical relevance could be found. False‐positive reactions from irritancy of the test material were suggested as a possible explanation. Objectives To assess whether positive patch test reactions to Brazilian propolis 10% pet. are allergic, irritant, or may be both. Materials and Methods In a prospective study, consecutive patients suspected of contact dermatitis were patch tested with Brazilian propolis in a dilution series of 10%, 3.3% and 1% in petrolatum. Results Of 200 consecutive patients, 56 (28%) had one or more positive Brazilian propolis patch tests. Eighteen propolis‐allergic individuals (32.1%) reacted only to the 10% concentration, 21 patients (37.5%) reacted to all 3 concentrations, 13 (23.2%) to 2 concentrations, and 4 (7.1%) to a lower concentration only. There was a strong association with fragrances, especially with the fragrance mixes 1 and 2. Conclusions Our data seem to indicate that the positive patch test reactions to Brazilian propolis 10% pet., or at least a large part thereof, are allergic in nature. Previous fragrance sensitisation may play an important role in the large number of positive patch tests to Brazilian propolis. 10.1111/cod.70002 http://creativecommons.org/licenses/by-nc-nd/4.0/
doi_str_mv	10.1111/cod.70002
format	Artículo Open Access
id	wiley_oa_10_1111_cod_70002
institution	Wiley Open Access
license_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
publishDate	2025
publisher	Wiley
record_format	wiley_oa
spellingShingle	Results of Patch Testing With a Brazilian Propolis Dilution Series Emma M. van Oers Norbertus A. Ipenburg Anton C. de Groot Thomas Rustemeyer Contact Dermatitis Results of Patch Testing With a Brazilian Propolis Dilution Series Emma M. van Oers Norbertus A. Ipenburg Anton C. de Groot Thomas Rustemeyer Contact Dermatitis ABSTRACT Background Patch testing with Brazilian propolis 10% pet. has yielded very high rates of positive reactions (> 20%). For most, no clinical relevance could be found. False‐positive reactions from irritancy of the test material were suggested as a possible explanation. Objectives To assess whether positive patch test reactions to Brazilian propolis 10% pet. are allergic, irritant, or may be both. Materials and Methods In a prospective study, consecutive patients suspected of contact dermatitis were patch tested with Brazilian propolis in a dilution series of 10%, 3.3% and 1% in petrolatum. Results Of 200 consecutive patients, 56 (28%) had one or more positive Brazilian propolis patch tests. Eighteen propolis‐allergic individuals (32.1%) reacted only to the 10% concentration, 21 patients (37.5%) reacted to all 3 concentrations, 13 (23.2%) to 2 concentrations, and 4 (7.1%) to a lower concentration only. There was a strong association with fragrances, especially with the fragrance mixes 1 and 2. Conclusions Our data seem to indicate that the positive patch test reactions to Brazilian propolis 10% pet., or at least a large part thereof, are allergic in nature. Previous fragrance sensitisation may play an important role in the large number of positive patch tests to Brazilian propolis. 10.1111/cod.70002 http://creativecommons.org/licenses/by-nc-nd/4.0/
title	Results of Patch Testing With a Brazilian Propolis Dilution Series
topic	Contact Dermatitis
url	https://onlinelibrary.wiley.com/doi/10.1111/cod.70002

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