1,6‐Hexanediol Diacrylate, Isocyanates and Other Skin Sensitizers Are Emerging Contact Allergens in Guardian Glucose Sensors
Fuente:
Wiley Open Access
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1867013592309563392 |
|---|---|
| author | Ella Dendooven Fleur Haentjens Silada Kanokrungsee Tania Naessens Emmy Tuenter Kenn Foubert Nina Hermans Eveline Dirinck Christophe De Block Olivier Aerts |
| author_facet | Ella Dendooven Fleur Haentjens Silada Kanokrungsee Tania Naessens Emmy Tuenter Kenn Foubert Nina Hermans Eveline Dirinck Christophe De Block Olivier Aerts Ella Dendooven Fleur Haentjens Silada Kanokrungsee Tania Naessens Emmy Tuenter Kenn Foubert Nina Hermans Eveline Dirinck Christophe De Block Olivier Aerts |
| collection | Wiley Open Access |
| contents | 1,6‐Hexanediol Diacrylate, Isocyanates and Other Skin Sensitizers Are Emerging Contact Allergens in Guardian Glucose Sensors Ella Dendooven Fleur Haentjens Silada Kanokrungsee Tania Naessens Emmy Tuenter Kenn Foubert Nina Hermans Eveline Dirinck Christophe De Block Olivier Aerts Contact Dermatitis ABSTRACT Background Allergic contact dermatitis (ACD) from diabetes devices remains a significant concern. Objective To report ACD from Guardian 3 and 4 glucose sensors (G3/4 sensors) due to multiple skin sensitizers, that is, isobornyl acrylate (IBOA), N,N ‐dimethylacrylamide (DMAA) and also 1,6‐hexanediol diacrylate (HDDA), isocyanates, colophonium derivatives, tert‐butylphenols (TBPs) and salicylates. Methods Twenty‐seven patients with ACD from G3/4 sensors, evaluated between January 2020 and December 2024, were patch‐tested to a baseline, acrylate, isocyanate and plastics and glue series. The sensors and their overtape (Oval Tape) were analysed with gas chromatography–mass spectrometry (GC‐MS). Results Most patients (44%) reacted to colophonium (derivatives), followed by IBOA (31%) and isocyanates (29%). Fewer, yet remarkable reactions were observed to HDDA (20%), TBPs (12.5%) and DMAA (8%). All IBOA and DMAA‐allergic patients had been previously sensitised by the FreeStyle I sensor, whereas patients using G3/4 sensors as their first diabetes device were not sensitised to these two allergens. Chemical analyses confirmed the presence of colophonium derivatives, IBOA, DMAA, HDDA, isocyanates, TBPs and, interestingly, also salicylates, as skin sensitizers in these sensors. Conclusions The newer glucose sensors Guardian 3 and 4 contain, besides IBOA and DMAA, also HDDA, together with a multitude of other skin sensitizers that put patients at risk of developing ACD. 10.1111/cod.70010 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/cod.70010 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cod_70010 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | 1,6‐Hexanediol Diacrylate, Isocyanates and Other Skin Sensitizers Are Emerging Contact Allergens in Guardian Glucose Sensors Ella Dendooven Fleur Haentjens Silada Kanokrungsee Tania Naessens Emmy Tuenter Kenn Foubert Nina Hermans Eveline Dirinck Christophe De Block Olivier Aerts Contact Dermatitis 1,6‐Hexanediol Diacrylate, Isocyanates and Other Skin Sensitizers Are Emerging Contact Allergens in Guardian Glucose Sensors Ella Dendooven Fleur Haentjens Silada Kanokrungsee Tania Naessens Emmy Tuenter Kenn Foubert Nina Hermans Eveline Dirinck Christophe De Block Olivier Aerts Contact Dermatitis ABSTRACT Background Allergic contact dermatitis (ACD) from diabetes devices remains a significant concern. Objective To report ACD from Guardian 3 and 4 glucose sensors (G3/4 sensors) due to multiple skin sensitizers, that is, isobornyl acrylate (IBOA), N,N ‐dimethylacrylamide (DMAA) and also 1,6‐hexanediol diacrylate (HDDA), isocyanates, colophonium derivatives, tert‐butylphenols (TBPs) and salicylates. Methods Twenty‐seven patients with ACD from G3/4 sensors, evaluated between January 2020 and December 2024, were patch‐tested to a baseline, acrylate, isocyanate and plastics and glue series. The sensors and their overtape (Oval Tape) were analysed with gas chromatography–mass spectrometry (GC‐MS). Results Most patients (44%) reacted to colophonium (derivatives), followed by IBOA (31%) and isocyanates (29%). Fewer, yet remarkable reactions were observed to HDDA (20%), TBPs (12.5%) and DMAA (8%). All IBOA and DMAA‐allergic patients had been previously sensitised by the FreeStyle I sensor, whereas patients using G3/4 sensors as their first diabetes device were not sensitised to these two allergens. Chemical analyses confirmed the presence of colophonium derivatives, IBOA, DMAA, HDDA, isocyanates, TBPs and, interestingly, also salicylates, as skin sensitizers in these sensors. Conclusions The newer glucose sensors Guardian 3 and 4 contain, besides IBOA and DMAA, also HDDA, together with a multitude of other skin sensitizers that put patients at risk of developing ACD. 10.1111/cod.70010 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | 1,6‐Hexanediol Diacrylate, Isocyanates and Other Skin Sensitizers Are Emerging Contact Allergens in Guardian Glucose Sensors |
| topic | Contact Dermatitis |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cod.70010 |