Contact Allergy to Preservatives and Emulsifiers in Patients With or Without Atopic Dermatitis
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| Formato: | Artículo Open Access |
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Wiley
2025
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| _version_ | 1867004924589506561 |
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| author | Mathilde Nødskov Aguirre Houlberg Line Brok Nørreslet Emma Louise Gersling Wolff Sebastian Vigand Svendsen Kristian Fredløv Mose Charlotte G. Mortz |
| author_facet | Mathilde Nødskov Aguirre Houlberg Line Brok Nørreslet Emma Louise Gersling Wolff Sebastian Vigand Svendsen Kristian Fredløv Mose Charlotte G. Mortz Mathilde Nødskov Aguirre Houlberg Line Brok Nørreslet Emma Louise Gersling Wolff Sebastian Vigand Svendsen Kristian Fredløv Mose Charlotte G. Mortz |
| collection | Wiley Open Access |
| contents | Contact Allergy to Preservatives and Emulsifiers in Patients With or Without Atopic Dermatitis Mathilde Nødskov Aguirre Houlberg Line Brok Nørreslet Emma Louise Gersling Wolff Sebastian Vigand Svendsen Kristian Fredløv Mose Charlotte G. Mortz Contact Dermatitis ABSTRACT Background Globally, 20% of children and up to 10% of adults have atopic dermatitis (AD). The impaired skin barrier function among AD patients may predispose them to a higher risk of contact allergy. Objectives This study aimed to evaluate the prevalence of contact allergy to preservatives and emulsifiers in AD patients compared with other dermatological patients (non‐AD) patch tested in the period 2006–2023, as well as assess clinical relevance. Methods A retrospective analysis of patch test data was performed among 7936 patients consecutively patch tested with preservatives and emulsifiers in the baseline series at the Department of Dermatology and Allergy Centre, Odense University Hospital, Denmark. Results Overall, no association between AD and contact allergy to preservatives was found. However, significantly more AD patients compared to non‐AD patients had contact allergy to 2‐Bromo‐2‐Nitropropane‐1,3‐Diol (1.8% versus 0.6%) and the emulsifier decyl glucoside (14.3% versus 3.1%). Non‐AD patients had significantly more contact allergy to benzisothiazolinone (15.4%) compared to AD patients (8.1%). Conclusions This study showed no overall association between AD and a higher risk of developing contact allergy to preservatives, although differences were identified for a few individual preservatives and for decyl glucoside. 10.1111/cod.70036 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/cod.70036 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cod_70036 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Contact Allergy to Preservatives and Emulsifiers in Patients With or Without Atopic Dermatitis Mathilde Nødskov Aguirre Houlberg Line Brok Nørreslet Emma Louise Gersling Wolff Sebastian Vigand Svendsen Kristian Fredløv Mose Charlotte G. Mortz Contact Dermatitis Contact Allergy to Preservatives and Emulsifiers in Patients With or Without Atopic Dermatitis Mathilde Nødskov Aguirre Houlberg Line Brok Nørreslet Emma Louise Gersling Wolff Sebastian Vigand Svendsen Kristian Fredløv Mose Charlotte G. Mortz Contact Dermatitis ABSTRACT Background Globally, 20% of children and up to 10% of adults have atopic dermatitis (AD). The impaired skin barrier function among AD patients may predispose them to a higher risk of contact allergy. Objectives This study aimed to evaluate the prevalence of contact allergy to preservatives and emulsifiers in AD patients compared with other dermatological patients (non‐AD) patch tested in the period 2006–2023, as well as assess clinical relevance. Methods A retrospective analysis of patch test data was performed among 7936 patients consecutively patch tested with preservatives and emulsifiers in the baseline series at the Department of Dermatology and Allergy Centre, Odense University Hospital, Denmark. Results Overall, no association between AD and contact allergy to preservatives was found. However, significantly more AD patients compared to non‐AD patients had contact allergy to 2‐Bromo‐2‐Nitropropane‐1,3‐Diol (1.8% versus 0.6%) and the emulsifier decyl glucoside (14.3% versus 3.1%). Non‐AD patients had significantly more contact allergy to benzisothiazolinone (15.4%) compared to AD patients (8.1%). Conclusions This study showed no overall association between AD and a higher risk of developing contact allergy to preservatives, although differences were identified for a few individual preservatives and for decyl glucoside. 10.1111/cod.70036 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Contact Allergy to Preservatives and Emulsifiers in Patients With or Without Atopic Dermatitis |
| topic | Contact Dermatitis |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cod.70036 |