Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2025
|
| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/cod.70052 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Results of GC – MS Analyses of 40 Extracts of Diabetes Devices Emma M. van Oers Anton C. de Groot Patrick Verolme Norbertus A. Ipenburg Thomas Rustemeyer Contact Dermatitis ABSTRACT Background Diagnostic patch testing in patients with suspected allergic Contact Dermatitis from glucose sensors, insulin pumps, and infusion sets is seriously hampered by a lack of information on the chemical composition of these diabetes devices. Objectives To identify the chemicals present in diabetes devices. Materials and Methods Forty acetone extracts of 27 devices (10 sensors, 3 patch pumps, 12 infusion sets and 2 single adhesives) were investigated by gas chromatography—mass spectrometry. Results Two hundred eighty four individual chemicals were identified. All 40 extracts contained one or more chemicals that were previously identified as allergens in diabetes devices causing allergic Contact Dermatitis. Fourteen of 27 devices (52%) contained one or more acrylates, 8 (30%) colophonium derivatives, all 27 (100%) one or two phenolic allergens (2,4‐di‐ tert ‐butylphenol, p ‐ tert‐ butylphenol, butylated hydroxytoluene), and 9 (33%) 1‐hydroxycyclohexyl phenyl ketone. None of the other chemicals were well‐known haptens, with the exception of bisphenol A, which was present in half of the extracts, in some cases in very high concentrations. Conclusions All products investigated contained chemicals already known to be sensitizers in diabetes devices. The data can help determine the relevance of positive patch tests, facilitate targeted patch testing with potential allergens and aid in advising safer alternatives for sensitized patients. 10.1111/cod.70052 http://creativecommons.org/licenses/by-nc-nd/4.0/