Genetic Insights Into Allergic Contact Dermatitis: Reassessing the Role of LCE3C_LCE3B Deletion
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Wiley
2025
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| author | Zeineb Ben Lamine Amen Moussa Marwa Bouhoula Razene Gerisha Sarra Sabbagh Imen Kacem Asma Aloui Souheil Chatti Aicha Brahem Ramzi Zemni Foued Ben Hadj Slama |
| author_facet | Zeineb Ben Lamine Amen Moussa Marwa Bouhoula Razene Gerisha Sarra Sabbagh Imen Kacem Asma Aloui Souheil Chatti Aicha Brahem Ramzi Zemni Foued Ben Hadj Slama Zeineb Ben Lamine Amen Moussa Marwa Bouhoula Razene Gerisha Sarra Sabbagh Imen Kacem Asma Aloui Souheil Chatti Aicha Brahem Ramzi Zemni Foued Ben Hadj Slama |
| collection | Wiley Open Access |
| contents | Genetic Insights Into Allergic Contact Dermatitis: Reassessing the Role of LCE3C_LCE3B Deletion Zeineb Ben Lamine Amen Moussa Marwa Bouhoula Razene Gerisha Sarra Sabbagh Imen Kacem Asma Aloui Souheil Chatti Aicha Brahem Ramzi Zemni Foued Ben Hadj Slama Contact Dermatitis ABSTRACT Background Allergic contact dermatitis (ACD) is a multifactorial inflammatory skin disorder. Polysensitisation, defined as hypersensitivity to ≥ 3 unrelated allergens, reflects a more severe clinical form. The LCE3C_LCE3B deletion, implicated in skin barrier dysfunction, has a yet unclear role in the susceptibility to ACD and polysensitisation. Objective This study aims to evaluate the association between LCE3C_LCE3B deletion and susceptibility to ACD and polysensitisation in the Tunisian population. Methods A case–control study included 94 confirmed ACD patients and 125 age‐ and sex‐matched controls without immune‐related diseases. Patch testing followed the European Baseline Series. LCE3C_LCE3B genotyping was performed using conventional three‐primer PCR after DNA extraction by the salting‐out method. Results Polysensitisation was observed in 33% of ACD cases. Genotyping of the LCE3C_LCE3B deletion did not reveal statistically significant differences in allelic or genotypic frequencies between ACD cases and controls. Furthermore, no statistically significant association was found between the LCE3C_LCE3B del and polysensitisation. Similarly, no significant associations were observed between the LCE3C_LCE3B deletion and sensitisation to metals, including nickel, cobalt and chromium. Conclusion No significant association was found between the LCE3C_LCE3B deletion and either ACD or polysensitisation. Larger studies are needed to clarify the genetic contribution to these conditions. 10.1111/cod.70058 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/cod.70058 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cod_70058 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Genetic Insights Into Allergic Contact Dermatitis: Reassessing the Role of LCE3C_LCE3B Deletion Zeineb Ben Lamine Amen Moussa Marwa Bouhoula Razene Gerisha Sarra Sabbagh Imen Kacem Asma Aloui Souheil Chatti Aicha Brahem Ramzi Zemni Foued Ben Hadj Slama Contact Dermatitis Genetic Insights Into Allergic Contact Dermatitis: Reassessing the Role of LCE3C_LCE3B Deletion Zeineb Ben Lamine Amen Moussa Marwa Bouhoula Razene Gerisha Sarra Sabbagh Imen Kacem Asma Aloui Souheil Chatti Aicha Brahem Ramzi Zemni Foued Ben Hadj Slama Contact Dermatitis ABSTRACT Background Allergic contact dermatitis (ACD) is a multifactorial inflammatory skin disorder. Polysensitisation, defined as hypersensitivity to ≥ 3 unrelated allergens, reflects a more severe clinical form. The LCE3C_LCE3B deletion, implicated in skin barrier dysfunction, has a yet unclear role in the susceptibility to ACD and polysensitisation. Objective This study aims to evaluate the association between LCE3C_LCE3B deletion and susceptibility to ACD and polysensitisation in the Tunisian population. Methods A case–control study included 94 confirmed ACD patients and 125 age‐ and sex‐matched controls without immune‐related diseases. Patch testing followed the European Baseline Series. LCE3C_LCE3B genotyping was performed using conventional three‐primer PCR after DNA extraction by the salting‐out method. Results Polysensitisation was observed in 33% of ACD cases. Genotyping of the LCE3C_LCE3B deletion did not reveal statistically significant differences in allelic or genotypic frequencies between ACD cases and controls. Furthermore, no statistically significant association was found between the LCE3C_LCE3B del and polysensitisation. Similarly, no significant associations were observed between the LCE3C_LCE3B deletion and sensitisation to metals, including nickel, cobalt and chromium. Conclusion No significant association was found between the LCE3C_LCE3B deletion and either ACD or polysensitisation. Larger studies are needed to clarify the genetic contribution to these conditions. 10.1111/cod.70058 http://creativecommons.org/licenses/by/4.0/ |
| title | Genetic Insights Into Allergic Contact Dermatitis: Reassessing the Role of LCE3C_LCE3B Deletion |
| topic | Contact Dermatitis |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cod.70058 |