Skin Barrier Biomarkers in Patch‐Induced and Clinical Allergic and Irritant Contact Dermatitis
Fuente:
Wiley Open Access
Salvato in:
| Autori principali: | , , , , , , , , |
|---|---|
| Natura: | Artículo Open Access |
| Pubblicazione: |
Wiley
2025
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1867013715984908288 |
|---|---|
| author | Sanja Kezic Florentine de Boer Nariman K. A. Metwally Karen Ghauharali‐van der Vlugt Femke S. Beers‐Stet Wouter Ouwerkerk Ivone Jakasa Thomas Rustemeyer Henk F. van der Molen |
| author_facet | Sanja Kezic Florentine de Boer Nariman K. A. Metwally Karen Ghauharali‐van der Vlugt Femke S. Beers‐Stet Wouter Ouwerkerk Ivone Jakasa Thomas Rustemeyer Henk F. van der Molen Sanja Kezic Florentine de Boer Nariman K. A. Metwally Karen Ghauharali‐van der Vlugt Femke S. Beers‐Stet Wouter Ouwerkerk Ivone Jakasa Thomas Rustemeyer Henk F. van der Molen |
| collection | Wiley Open Access |
| contents | Skin Barrier Biomarkers in Patch‐Induced and Clinical Allergic and Irritant Contact Dermatitis Sanja Kezic Florentine de Boer Nariman K. A. Metwally Karen Ghauharali‐van der Vlugt Femke S. Beers‐Stet Wouter Ouwerkerk Ivone Jakasa Thomas Rustemeyer Henk F. van der Molen Contact Dermatitis ABSTRACT Background Skin barrier impairment is central to irritant (ICD) and allergic contact dermatitis (ACD). Stratum corneum (SC) components cholesterol sulphate (CholSulph), glucosylcholesterol (CholGlc) and natural moisturising factor (NMF) are critical for barrier function, but their changes in ICD and ACD remain underexplored. Objectives To measure CholSulph, CholGlc, NMF and IL‐1α in patch‐induced ICD and ACD and in hand dermatitis (HD) diagnosed as ICD or ACD. Methods SC samples were collected from HD patients undergoing patch testing. Biomarkers were analysed in positive reactions to sodium lauryl sulphate (ICD, n = 44), allergens (ACD, n = 113; nickel, chromium, methylisothiazolinone [MI]), lesional HD skin ( n = 45) and control (empty chamber, n = 121). Results CholGlc was significantly elevated in patch‐induced ICD and ACD. CholSulph was increased in ICD and chromium‐ and MI‐induced ACD. NMF decreased in ICD, while IL‐1α decreased in ICD and chromium ACD. Chromium induced the strongest response, nickel the weakest. In HD, ICD and ACD showed elevated CholGlc, reduced NMF and IL‐1α, with CholSulph increased only in ACD. No biomarker differences were detected between clinical ICD and ACD. Conclusions Both induced and clinical ICD and ACD show consistent SC biomarker changes reflecting barrier dysfunction, with no differences between clinical ICD and ACD. 10.1111/cod.70070 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/cod.70070 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_cod_70070 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Skin Barrier Biomarkers in Patch‐Induced and Clinical Allergic and Irritant Contact Dermatitis Sanja Kezic Florentine de Boer Nariman K. A. Metwally Karen Ghauharali‐van der Vlugt Femke S. Beers‐Stet Wouter Ouwerkerk Ivone Jakasa Thomas Rustemeyer Henk F. van der Molen Contact Dermatitis Skin Barrier Biomarkers in Patch‐Induced and Clinical Allergic and Irritant Contact Dermatitis Sanja Kezic Florentine de Boer Nariman K. A. Metwally Karen Ghauharali‐van der Vlugt Femke S. Beers‐Stet Wouter Ouwerkerk Ivone Jakasa Thomas Rustemeyer Henk F. van der Molen Contact Dermatitis ABSTRACT Background Skin barrier impairment is central to irritant (ICD) and allergic contact dermatitis (ACD). Stratum corneum (SC) components cholesterol sulphate (CholSulph), glucosylcholesterol (CholGlc) and natural moisturising factor (NMF) are critical for barrier function, but their changes in ICD and ACD remain underexplored. Objectives To measure CholSulph, CholGlc, NMF and IL‐1α in patch‐induced ICD and ACD and in hand dermatitis (HD) diagnosed as ICD or ACD. Methods SC samples were collected from HD patients undergoing patch testing. Biomarkers were analysed in positive reactions to sodium lauryl sulphate (ICD, n = 44), allergens (ACD, n = 113; nickel, chromium, methylisothiazolinone [MI]), lesional HD skin ( n = 45) and control (empty chamber, n = 121). Results CholGlc was significantly elevated in patch‐induced ICD and ACD. CholSulph was increased in ICD and chromium‐ and MI‐induced ACD. NMF decreased in ICD, while IL‐1α decreased in ICD and chromium ACD. Chromium induced the strongest response, nickel the weakest. In HD, ICD and ACD showed elevated CholGlc, reduced NMF and IL‐1α, with CholSulph increased only in ACD. No biomarker differences were detected between clinical ICD and ACD. Conclusions Both induced and clinical ICD and ACD show consistent SC biomarker changes reflecting barrier dysfunction, with no differences between clinical ICD and ACD. 10.1111/cod.70070 http://creativecommons.org/licenses/by/4.0/ |
| title | Skin Barrier Biomarkers in Patch‐Induced and Clinical Allergic and Irritant Contact Dermatitis |
| topic | Contact Dermatitis |
| url | https://onlinelibrary.wiley.com/doi/10.1111/cod.70070 |