Low anterior resection syndrome phenotypes—Different symptom profiles for different patients
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2024
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| author | Sireesha Koneru Julie Cornish Pierre H. Chapuis Anil Keshava Matthew J. F. X. Rickard Kheng‐Seong Ng |
| author_facet | Sireesha Koneru Julie Cornish Pierre H. Chapuis Anil Keshava Matthew J. F. X. Rickard Kheng‐Seong Ng Sireesha Koneru Julie Cornish Pierre H. Chapuis Anil Keshava Matthew J. F. X. Rickard Kheng‐Seong Ng |
| collection | Wiley Open Access |
| contents | Low anterior resection syndrome phenotypes—Different symptom profiles for different patients Sireesha Koneru Julie Cornish Pierre H. Chapuis Anil Keshava Matthew J. F. X. Rickard Kheng‐Seong Ng Colorectal Disease AbstractAimAttention is increasingly being turned to functional outcomes as being central to colorectal cancer (CRC) survivorship. The current literature may underestimate the impact of evacuatory dysfunction on patient satisfaction with bowel function after anterior resection (AR) for CRC. The aim of this study was to investigate the impact of post‐AR symptoms of storage and evacuatory dysfunction on patient satisfaction and health‐related quality of life (HRQoL).MethodA cross‐sectional study was performed at an Australian hospital of patients post‐AR for CRC (2012–2021). The postoperative bowel function scores used were: low anterior resection syndrome (LARS), St Mark's incontinence, Cleveland Clinic constipation and Altomare obstructive defaecation syndrome scores. Eight ‘storage’ and ‘evacuatory’ dysfunction symptoms were derived. A seven‐point Likert scale measured patient satisfaction. The SF36v2® measured HRQoL. Linear regression assessed the association between symptoms, patient satisfaction and HRQoL.ResultsOverall, 248 patients participated (mean age 70.8 years, 57.3% male), comprising 103 with rectal cancer and 145 with sigmoid cancer. Of the symptoms that had a negative impact on patient satisfaction, six reflected evacuatory dysfunction, namely excessive straining (p < 0.001), one or more unsuccessful bowel movement attempt(s)/24 h (p < 0.001), anal/vaginal digitation (p = 0.005), regular enema use (p = 0.004), toilet revisiting (p = 0.004) and >10 min toileting (p = 0.004), and four reflected storage dysfunction, namely leaking flatus (p = 0.002), faecal urgency (p = 0.005), use of antidiarrhoeal medication (p = 0.001) and incontinence‐related lifestyle alterations (p < 0.001). A total of 130 patients (53.5%) had ‘no LARS’, 56 (23.1%) had ‘minor LARS’ and 57 (23.4%) had ‘major LARS’. Fifty‐seven (44.5%) patients classified as having ‘no LARS’ had evacuatory dysfunction.ConclusionPostoperative storage and evacuatory dysfunction symptoms have an adverse impact on patient satisfaction and HRQoL post‐AR. The importance of comprehensively documenting symptoms of evacuatory dysfunction is highlighted. Further research is required to develop a patient satisfaction‐weighted LARS‐specific HRQoL instrument. 10.1111/codi.17034 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1111/codi.17034 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_codi_17034 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Low anterior resection syndrome phenotypes—Different symptom profiles for different patients Sireesha Koneru Julie Cornish Pierre H. Chapuis Anil Keshava Matthew J. F. X. Rickard Kheng‐Seong Ng Colorectal Disease Low anterior resection syndrome phenotypes—Different symptom profiles for different patients Sireesha Koneru Julie Cornish Pierre H. Chapuis Anil Keshava Matthew J. F. X. Rickard Kheng‐Seong Ng Colorectal Disease AbstractAimAttention is increasingly being turned to functional outcomes as being central to colorectal cancer (CRC) survivorship. The current literature may underestimate the impact of evacuatory dysfunction on patient satisfaction with bowel function after anterior resection (AR) for CRC. The aim of this study was to investigate the impact of post‐AR symptoms of storage and evacuatory dysfunction on patient satisfaction and health‐related quality of life (HRQoL).MethodA cross‐sectional study was performed at an Australian hospital of patients post‐AR for CRC (2012–2021). The postoperative bowel function scores used were: low anterior resection syndrome (LARS), St Mark's incontinence, Cleveland Clinic constipation and Altomare obstructive defaecation syndrome scores. Eight ‘storage’ and ‘evacuatory’ dysfunction symptoms were derived. A seven‐point Likert scale measured patient satisfaction. The SF36v2® measured HRQoL. Linear regression assessed the association between symptoms, patient satisfaction and HRQoL.ResultsOverall, 248 patients participated (mean age 70.8 years, 57.3% male), comprising 103 with rectal cancer and 145 with sigmoid cancer. Of the symptoms that had a negative impact on patient satisfaction, six reflected evacuatory dysfunction, namely excessive straining (p < 0.001), one or more unsuccessful bowel movement attempt(s)/24 h (p < 0.001), anal/vaginal digitation (p = 0.005), regular enema use (p = 0.004), toilet revisiting (p = 0.004) and >10 min toileting (p = 0.004), and four reflected storage dysfunction, namely leaking flatus (p = 0.002), faecal urgency (p = 0.005), use of antidiarrhoeal medication (p = 0.001) and incontinence‐related lifestyle alterations (p < 0.001). A total of 130 patients (53.5%) had ‘no LARS’, 56 (23.1%) had ‘minor LARS’ and 57 (23.4%) had ‘major LARS’. Fifty‐seven (44.5%) patients classified as having ‘no LARS’ had evacuatory dysfunction.ConclusionPostoperative storage and evacuatory dysfunction symptoms have an adverse impact on patient satisfaction and HRQoL post‐AR. The importance of comprehensively documenting symptoms of evacuatory dysfunction is highlighted. Further research is required to develop a patient satisfaction‐weighted LARS‐specific HRQoL instrument. 10.1111/codi.17034 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Low anterior resection syndrome phenotypes—Different symptom profiles for different patients |
| topic | Colorectal Disease |
| url | https://onlinelibrary.wiley.com/doi/10.1111/codi.17034 |