Oncological outcome following Hartmann's procedure compared with anterior resection and abdominoperineal resection for rectal cancer—The type of procedure does not influence local recurrence or distant metastasis: A population‐based study
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| Format: | Artículo Open Access |
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2024
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| author | Elin Mariusdottir Fredrik Jörgren Marie‐Louise Lydrup Pamela Buchwald |
| author_facet | Elin Mariusdottir Fredrik Jörgren Marie‐Louise Lydrup Pamela Buchwald Elin Mariusdottir Fredrik Jörgren Marie‐Louise Lydrup Pamela Buchwald |
| collection | Wiley Open Access |
| contents | Oncological outcome following Hartmann's procedure compared with anterior resection and abdominoperineal resection for rectal cancer—The type of procedure does not influence local recurrence or distant metastasis: A population‐based study Elin Mariusdottir Fredrik Jörgren Marie‐Louise Lydrup Pamela Buchwald Colorectal Disease AbstractAimThe type of surgical procedure used in rectal cancer treatment may affect cancer recurrence. The aim of this study was to determine whether the type of procedure influences oncological outcomes in rectal cancer surgery.MethodWe gathered data from the Swedish Colorectal Cancer Registry regarding patients with TNM Stage I–III rectal cancer who underwent R0/R1 surgery from 2013 to 2017. The outcomes after Hartmann's procedure (HP), anterior resection (AR) and abdominoperineal resection (APR) were compared, and a multivariable Cox regression analysis was performed. The primary outcome of the study was the local recurrence rate. The secondary outcomes were distant metastasis, disease‐free survival and overall survival at 5 years as well as risk factors for local recurrence.ResultsA total of 4741 patients were included in the study: 614 underwent HP, 3075 underwent AR and 1052 underwent APR. Multivariable Cox regression revealed no difference in local recurrence, distant metastasis or disease‐free survival. Overall survival was higher following AR (OR 0.62, CI 0.54–0.72). Risk factors for local recurrence were intraoperative bowel perforation (OR 2.41, CI 1.33–4.40), a pT4 tumour (OR 1.93, CI 1.11–3.4) and a positive circumferential resection margin (OR 5.62, CI 3.28–9.61).ConclusionsThis nationwide study showed that the type of procedure did not affect the local recurrence rate or distant metastasis. In patients who are unfit for restorative surgery, HP is a viable alternative with oncological outcomes similar to those of APR. 10.1111/codi.17163 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/codi.17163 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_codi_17163 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Oncological outcome following Hartmann's procedure compared with anterior resection and abdominoperineal resection for rectal cancer—The type of procedure does not influence local recurrence or distant metastasis: A population‐based study Elin Mariusdottir Fredrik Jörgren Marie‐Louise Lydrup Pamela Buchwald Colorectal Disease Oncological outcome following Hartmann's procedure compared with anterior resection and abdominoperineal resection for rectal cancer—The type of procedure does not influence local recurrence or distant metastasis: A population‐based study Elin Mariusdottir Fredrik Jörgren Marie‐Louise Lydrup Pamela Buchwald Colorectal Disease AbstractAimThe type of surgical procedure used in rectal cancer treatment may affect cancer recurrence. The aim of this study was to determine whether the type of procedure influences oncological outcomes in rectal cancer surgery.MethodWe gathered data from the Swedish Colorectal Cancer Registry regarding patients with TNM Stage I–III rectal cancer who underwent R0/R1 surgery from 2013 to 2017. The outcomes after Hartmann's procedure (HP), anterior resection (AR) and abdominoperineal resection (APR) were compared, and a multivariable Cox regression analysis was performed. The primary outcome of the study was the local recurrence rate. The secondary outcomes were distant metastasis, disease‐free survival and overall survival at 5 years as well as risk factors for local recurrence.ResultsA total of 4741 patients were included in the study: 614 underwent HP, 3075 underwent AR and 1052 underwent APR. Multivariable Cox regression revealed no difference in local recurrence, distant metastasis or disease‐free survival. Overall survival was higher following AR (OR 0.62, CI 0.54–0.72). Risk factors for local recurrence were intraoperative bowel perforation (OR 2.41, CI 1.33–4.40), a pT4 tumour (OR 1.93, CI 1.11–3.4) and a positive circumferential resection margin (OR 5.62, CI 3.28–9.61).ConclusionsThis nationwide study showed that the type of procedure did not affect the local recurrence rate or distant metastasis. In patients who are unfit for restorative surgery, HP is a viable alternative with oncological outcomes similar to those of APR. 10.1111/codi.17163 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Oncological outcome following Hartmann's procedure compared with anterior resection and abdominoperineal resection for rectal cancer—The type of procedure does not influence local recurrence or distant metastasis: A population‐based study |
| topic | Colorectal Disease |
| url | https://onlinelibrary.wiley.com/doi/10.1111/codi.17163 |