Contemporary practices in abdominoperineal resection for early‐stage rectal cancer in the United States
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Wiley
2025
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| author | Totadri Dhimal Bailey K. Hilty Chu Anthony Loria Megan Boyer Xueya Cai Yue Li Fernando Colugnati Paula Cupertino Erika E. Ramsdale Fergal J. Fleming |
| author_facet | Totadri Dhimal Bailey K. Hilty Chu Anthony Loria Megan Boyer Xueya Cai Yue Li Fernando Colugnati Paula Cupertino Erika E. Ramsdale Fergal J. Fleming Totadri Dhimal Bailey K. Hilty Chu Anthony Loria Megan Boyer Xueya Cai Yue Li Fernando Colugnati Paula Cupertino Erika E. Ramsdale Fergal J. Fleming |
| collection | Wiley Open Access |
| contents | Contemporary practices in abdominoperineal resection for early‐stage rectal cancer in the United States Totadri Dhimal Bailey K. Hilty Chu Anthony Loria Megan Boyer Xueya Cai Yue Li Fernando Colugnati Paula Cupertino Erika E. Ramsdale Fergal J. Fleming Colorectal Disease AbstractAimIn contrast to significant advances in organ preservation in locally advanced rectal cancer, the contemporary management of early‐stage rectal cancer, including the frequency of abdominoperineal resections, remains largely unexplored in the United States. Therefore, we assessed the utilization of neoadjuvant therapy and oncological resections in early‐stage rectal cancer patients.Study designThis is a retrospective cohort study of patients with cT1–T3N0 rectal cancer who underwent proctectomies between 2016 and 2022 in the National Surgical Quality Improvement Project proctectomy files. Multivariable logistic regression was used to identify factors associated with abdominoperineal resections and Kendall's tau statistics to evaluate clinical‐pathological staging agreement.ResultsIn all, 3078 patients (29.6% cT1–2N0, 70.4% cT3N0) were included with 55.3% of tumours <5 cm from the anal verge. Overall, 58.2% received neoadjuvant therapy within 3 months of surgery (30.6% for cT1–T2N0 vs. 69.8% for cT3N0, P < 0.001), and 58.6% underwent abdominoperineal resection (55.5% for cT1–T2N0 vs. 59.9% for cT3N0, P = 0.058). The adjusted odds of undergoing abdominoperineal resection were associated with increasing age (OR 1.4 per every 10‐year increase; 95% CI 1.2–1.5), cT3N0 tumours (OR 1.7; 95% CI 1.1–2.7) and tumour location <5 cm from the anal verge (OR 10.6; 95% CI 7.7–14.7). There was a weak clinical‐pathological T staging correlation (Kendal tau coefficient 0.25; 95% CI 0.20–0.29).ConclusionIn this large cohort of patients with early‐stage rectal cancer with high rates of neoadjuvant therapy, over half of patients underwent abdominoperineal resection and one in five had a pathological complete response. These findings underscore opportunities for organ preservation in early‐stage rectal cancer, suggesting that treatments typically reserved for locally advanced disease may extend to early stages with the completion of ongoing clinical trials. 10.1111/codi.17281 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/codi.17281 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_codi_17281 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Contemporary practices in abdominoperineal resection for early‐stage rectal cancer in the United States Totadri Dhimal Bailey K. Hilty Chu Anthony Loria Megan Boyer Xueya Cai Yue Li Fernando Colugnati Paula Cupertino Erika E. Ramsdale Fergal J. Fleming Colorectal Disease Contemporary practices in abdominoperineal resection for early‐stage rectal cancer in the United States Totadri Dhimal Bailey K. Hilty Chu Anthony Loria Megan Boyer Xueya Cai Yue Li Fernando Colugnati Paula Cupertino Erika E. Ramsdale Fergal J. Fleming Colorectal Disease AbstractAimIn contrast to significant advances in organ preservation in locally advanced rectal cancer, the contemporary management of early‐stage rectal cancer, including the frequency of abdominoperineal resections, remains largely unexplored in the United States. Therefore, we assessed the utilization of neoadjuvant therapy and oncological resections in early‐stage rectal cancer patients.Study designThis is a retrospective cohort study of patients with cT1–T3N0 rectal cancer who underwent proctectomies between 2016 and 2022 in the National Surgical Quality Improvement Project proctectomy files. Multivariable logistic regression was used to identify factors associated with abdominoperineal resections and Kendall's tau statistics to evaluate clinical‐pathological staging agreement.ResultsIn all, 3078 patients (29.6% cT1–2N0, 70.4% cT3N0) were included with 55.3% of tumours <5 cm from the anal verge. Overall, 58.2% received neoadjuvant therapy within 3 months of surgery (30.6% for cT1–T2N0 vs. 69.8% for cT3N0, P < 0.001), and 58.6% underwent abdominoperineal resection (55.5% for cT1–T2N0 vs. 59.9% for cT3N0, P = 0.058). The adjusted odds of undergoing abdominoperineal resection were associated with increasing age (OR 1.4 per every 10‐year increase; 95% CI 1.2–1.5), cT3N0 tumours (OR 1.7; 95% CI 1.1–2.7) and tumour location <5 cm from the anal verge (OR 10.6; 95% CI 7.7–14.7). There was a weak clinical‐pathological T staging correlation (Kendal tau coefficient 0.25; 95% CI 0.20–0.29).ConclusionIn this large cohort of patients with early‐stage rectal cancer with high rates of neoadjuvant therapy, over half of patients underwent abdominoperineal resection and one in five had a pathological complete response. These findings underscore opportunities for organ preservation in early‐stage rectal cancer, suggesting that treatments typically reserved for locally advanced disease may extend to early stages with the completion of ongoing clinical trials. 10.1111/codi.17281 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Contemporary practices in abdominoperineal resection for early‐stage rectal cancer in the United States |
| topic | Colorectal Disease |
| url | https://onlinelibrary.wiley.com/doi/10.1111/codi.17281 |