Controlling Nutritional Status (CONUT) as a predictor of survival and complications among colorectal cancer patients: A systematic review and meta‐analysis
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| Formato: | Artículo Open Access |
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Wiley
2025
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| _version_ | 1867006664567160832 |
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| author | Akhil Deepak Vatvani Pratik Patel Dhienda Cempaka Shahannaz Theo Audi Yanto Timotius Ivan Hariyanto |
| author_facet | Akhil Deepak Vatvani Pratik Patel Dhienda Cempaka Shahannaz Theo Audi Yanto Timotius Ivan Hariyanto Akhil Deepak Vatvani Pratik Patel Dhienda Cempaka Shahannaz Theo Audi Yanto Timotius Ivan Hariyanto |
| collection | Wiley Open Access |
| contents | Controlling Nutritional Status (CONUT) as a predictor of survival and complications among colorectal cancer patients: A systematic review and meta‐analysis Akhil Deepak Vatvani Pratik Patel Dhienda Cempaka Shahannaz Theo Audi Yanto Timotius Ivan Hariyanto Colorectal Disease AbstractAimThe Controlling Nutritional Status (CONUT) scoring system integrates components of inflammation and nutrition, both of which significantly influence cancer progression. However, its utility in colorectal cancer remains ambiguous and contradictory. The aim of this study is to evaluate the efficacy of the CONUT score in forecasting the prognosis of colorectal cancer patients.MethodA thorough search was performed on the Scopus, Medline, Europe PMC and Cochrane Library databases up to 18 November 2024. This review includes evidence that investigates the correlation between the CONUT score and outcomes in colorectal cancer patients. We utilized random‐effects models to evaluate the hazard ratio (HR) for the occurrence of the outcomes.ResultsA total of 22 papers were included in the systematic review, with 20 of them included in the meta‐analysis. The pooled analysis from multivariable data revealed that a high CONUT score was an independent predictor of poor overall survival (HR 2.02, 95% CI 1.74–2.34, p < 0.00001), disease‐free survival (HR 2.96, 95% CI 1.28–6.85, p = 0.01), cancer‐specific survival (HR 3.93, 95% CI 2.16–7.15, p < 0.00001) and recurrence‐free survival (HR 1.76, 95% CI 1.42–2.19, p < 0.00001) among colorectal cancer patients. A high CONUT score was also correlated with a greater likelihood of postoperative complications than a low CONUT score in colorectal cancer patients (HR 2.04, 95% CI 1.44–2.89, p < 0.0001).ConclusionsThis study suggests the prognostic capability of the CONUT score in forecasting the short‐ and long‐term outcomes of colorectal cancer patients; it therefore can be routinely calculated to stratify the risk of patients. 10.1111/codi.70120 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/codi.70120 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_codi_70120 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Controlling Nutritional Status (CONUT) as a predictor of survival and complications among colorectal cancer patients: A systematic review and meta‐analysis Akhil Deepak Vatvani Pratik Patel Dhienda Cempaka Shahannaz Theo Audi Yanto Timotius Ivan Hariyanto Colorectal Disease Controlling Nutritional Status (CONUT) as a predictor of survival and complications among colorectal cancer patients: A systematic review and meta‐analysis Akhil Deepak Vatvani Pratik Patel Dhienda Cempaka Shahannaz Theo Audi Yanto Timotius Ivan Hariyanto Colorectal Disease AbstractAimThe Controlling Nutritional Status (CONUT) scoring system integrates components of inflammation and nutrition, both of which significantly influence cancer progression. However, its utility in colorectal cancer remains ambiguous and contradictory. The aim of this study is to evaluate the efficacy of the CONUT score in forecasting the prognosis of colorectal cancer patients.MethodA thorough search was performed on the Scopus, Medline, Europe PMC and Cochrane Library databases up to 18 November 2024. This review includes evidence that investigates the correlation between the CONUT score and outcomes in colorectal cancer patients. We utilized random‐effects models to evaluate the hazard ratio (HR) for the occurrence of the outcomes.ResultsA total of 22 papers were included in the systematic review, with 20 of them included in the meta‐analysis. The pooled analysis from multivariable data revealed that a high CONUT score was an independent predictor of poor overall survival (HR 2.02, 95% CI 1.74–2.34, p < 0.00001), disease‐free survival (HR 2.96, 95% CI 1.28–6.85, p = 0.01), cancer‐specific survival (HR 3.93, 95% CI 2.16–7.15, p < 0.00001) and recurrence‐free survival (HR 1.76, 95% CI 1.42–2.19, p < 0.00001) among colorectal cancer patients. A high CONUT score was also correlated with a greater likelihood of postoperative complications than a low CONUT score in colorectal cancer patients (HR 2.04, 95% CI 1.44–2.89, p < 0.0001).ConclusionsThis study suggests the prognostic capability of the CONUT score in forecasting the short‐ and long‐term outcomes of colorectal cancer patients; it therefore can be routinely calculated to stratify the risk of patients. 10.1111/codi.70120 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Controlling Nutritional Status (CONUT) as a predictor of survival and complications among colorectal cancer patients: A systematic review and meta‐analysis |
| topic | Colorectal Disease |
| url | https://onlinelibrary.wiley.com/doi/10.1111/codi.70120 |