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| Main Authors: | , , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2026
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/codi.70399 |
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Table of Contents:
- Comparing various bowel preparation regimens in constipated patients undergoing colonoscopy: A systematic review and network meta‐analysis of randomised controlled trials Zain ul Abideen Muhammad Hassan Waseem Areeba Shoaib Noor‐ul‐Huda Ramzan Muhammad Tayyab Amer Ch Pawan Kumar Thada Prasun Kumar Jalal Colorectal Disease Abstract Background Colonoscopy effectiveness in detecting colorectal carcinoma depends on adequate bowel preparation (ABP). This network meta‐analysis assesses the efficacy and safety of various bowel preparation regimens in patients with constipation. Methods PubMed, Cochrane Central and ScienceDirect were searched till April 2025. A frequentist network meta‐analysis was performed using the ‘meta’ and ‘netmeta’ packages on R version 4.3.3. The ranking was done using P‐scores. Results Fifteen randomised controlled trials were included. Compared with 4 L polyethylene glycol (PEG), 3 L PEG + 3d‐linaclotide (Lin) (risk ratio [RR] = 1.29; 95% confidence intervals [CI]: [1.12, 1.47]), 4 L PEG + 1d‐Lin (RR = 1.25; 95% CI: [1.04, 1.51]), sodium phosphate (NaP) + bisacodyl (RR = 1.52; 95% CI: [1.09, 2.10]), probiotic 14d + NaP (RR = 3.59; 95% CI: [1.83, 7.04]) may show improvements in the rate of ABP. The probiotic 14d + NaP regimen was ranked best regarding ABP (P‐score = 0.99) and bloating (P‐score = 0.84). The 3 L PEG + 3d‐Lin showed a reduction (RR = 0.18; 95% CI: [0.04, 0.88]) in abdominal pain and was ranked best regarding abdominal pain (P‐score = 0.89) and vomiting (P‐score = 0.80). The 4 L PEG + 1d‐Lin was ranked best (P‐score = 0.77) in terms of nausea. Conclusion The 14d‐probiotics + NaP and 3 L PEG + 3d‐Lin may be among the more effective and tolerable bowel preparation regimens. While adverse events were similar, the observed reduction in abdominal pain with 3 L PEG + 3d‐Lin may suggest improved patient comfort and adherence. 10.1111/codi.70399 http://onlinelibrary.wiley.com/termsAndConditions#vor