Lung transplantation in HIV seropositive recipients: An analysis of the UNOS registry
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| Formato: | Artículo Open Access |
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Wiley
2024
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| _version_ | 1867016483230449664 |
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| author | Jack K. Donohue Ernest G. Chan Sarah Clifford John P. Ryan Masashi Furukawa Ghady Haidar Alessandro Bertani Chadi A. Hage Pablo G. Sanchez |
| author_facet | Jack K. Donohue Ernest G. Chan Sarah Clifford John P. Ryan Masashi Furukawa Ghady Haidar Alessandro Bertani Chadi A. Hage Pablo G. Sanchez Jack K. Donohue Ernest G. Chan Sarah Clifford John P. Ryan Masashi Furukawa Ghady Haidar Alessandro Bertani Chadi A. Hage Pablo G. Sanchez |
| collection | Wiley Open Access |
| contents | Lung transplantation in HIV seropositive recipients: An analysis of the UNOS registry Jack K. Donohue Ernest G. Chan Sarah Clifford John P. Ryan Masashi Furukawa Ghady Haidar Alessandro Bertani Chadi A. Hage Pablo G. Sanchez Clinical Transplantation AbstractBackgroundExperience with lung transplantation (LT) in patients with human immunodeficiency virus (HIV) is limited. Many studies have demonstrated the success of kidney and liver transplantation in HIV‐seropositive (HIV+) patients. Our objective was to conduct a national registry analysis comparing LT outcomes in HIV+ to HIV‐seronegative (HIV−) recipients.MethodsThe United Network for Organ Sharing database was queried to identify LTs performed in adult HIV+ patients between 2016 and 2023. Patients with unknown HIV status, multiorgan transplants, and redo transplants were excluded. The primary endpoints were mortality and graft rejection. Survival time was analyzed using Kaplan–Meier analysis.ResultsThe study included 17 487 patients, 67 of whom were HIV+. HIV+ recipients were younger (59 vs. 62 years, p = .02), had higher pulmonary arterial pressure (28 vs. 25 mm Hg, p = .04), and higher lung allocation scores (47 vs. 41, p = .01) relative to HIV− recipients. There were no differences in graft/recipient survival time between groups. HIV+ recipients had higher rates of post‐transplant dialysis (18% vs. 8.4%, p = .01), but otherwise had similar post‐transplant outcomes to HIV‐recipients.ConclusionsThis national registry analysis suggests LT outcomes in HIV+ patients are not inferior to outcomes in HIV− patients and that well‐selected HIV+ recipients can achieve comparable patient and graft survival rates relative to HIV− recipients. 10.1111/ctr.15246 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.15246 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15246 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Lung transplantation in HIV seropositive recipients: An analysis of the UNOS registry Jack K. Donohue Ernest G. Chan Sarah Clifford John P. Ryan Masashi Furukawa Ghady Haidar Alessandro Bertani Chadi A. Hage Pablo G. Sanchez Clinical Transplantation Lung transplantation in HIV seropositive recipients: An analysis of the UNOS registry Jack K. Donohue Ernest G. Chan Sarah Clifford John P. Ryan Masashi Furukawa Ghady Haidar Alessandro Bertani Chadi A. Hage Pablo G. Sanchez Clinical Transplantation AbstractBackgroundExperience with lung transplantation (LT) in patients with human immunodeficiency virus (HIV) is limited. Many studies have demonstrated the success of kidney and liver transplantation in HIV‐seropositive (HIV+) patients. Our objective was to conduct a national registry analysis comparing LT outcomes in HIV+ to HIV‐seronegative (HIV−) recipients.MethodsThe United Network for Organ Sharing database was queried to identify LTs performed in adult HIV+ patients between 2016 and 2023. Patients with unknown HIV status, multiorgan transplants, and redo transplants were excluded. The primary endpoints were mortality and graft rejection. Survival time was analyzed using Kaplan–Meier analysis.ResultsThe study included 17 487 patients, 67 of whom were HIV+. HIV+ recipients were younger (59 vs. 62 years, p = .02), had higher pulmonary arterial pressure (28 vs. 25 mm Hg, p = .04), and higher lung allocation scores (47 vs. 41, p = .01) relative to HIV− recipients. There were no differences in graft/recipient survival time between groups. HIV+ recipients had higher rates of post‐transplant dialysis (18% vs. 8.4%, p = .01), but otherwise had similar post‐transplant outcomes to HIV‐recipients.ConclusionsThis national registry analysis suggests LT outcomes in HIV+ patients are not inferior to outcomes in HIV− patients and that well‐selected HIV+ recipients can achieve comparable patient and graft survival rates relative to HIV− recipients. 10.1111/ctr.15246 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Lung transplantation in HIV seropositive recipients: An analysis of the UNOS registry |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15246 |