Tixagevimab/cilgavimab for the prevention of COVID‐19 in solid organ transplant recipients
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| Formato: | Artículo Open Access |
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Wiley
2024
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| _version_ | 1867005357481525248 |
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| author | Emily Eribes Cassandra Votruba Tyler Tinkham Angela Huang Dan Ilges Katie Kunze Madeline Hudson |
| author_facet | Emily Eribes Cassandra Votruba Tyler Tinkham Angela Huang Dan Ilges Katie Kunze Madeline Hudson Emily Eribes Cassandra Votruba Tyler Tinkham Angela Huang Dan Ilges Katie Kunze Madeline Hudson |
| collection | Wiley Open Access |
| contents | Tixagevimab/cilgavimab for the prevention of COVID‐19 in solid organ transplant recipients Emily Eribes Cassandra Votruba Tyler Tinkham Angela Huang Dan Ilges Katie Kunze Madeline Hudson Clinical Transplantation AbstractTixagevimab/cilgavimab (tix/cil) received emergency use authorization in December 2021 for pre‐exposure prophylaxis against COVID‐19 in moderately to severely immunocompromised patients. Our study aimed to describe the incidence of COVID‐19 infection and assess the immunologic risks associated with tix/cil in kidney, pancreas, liver, and heart transplant recipients. Retrospective chart review was completed to provide descriptive analysis. Outcomes data included COVID‐19 infection, severity of COVID‐19 infection, graft function, and rejection. Safety outcomes included cardiovascular (CV) and hypersensitivity events post tix/cil administration. A total of 410 transplant patients were included in the analysis: 20 heart, 92 liver, 243 kidney, 25 simultaneous pancreas/kidney, 23 simultaneous liver/kidney, and seven simultaneous heart/kidney. Twenty‐seven (6.5%) patients tested positive for COVID‐19 via PCR or antigen test post tix/cil. No apparent difference was observed in patients testing positive for COVID‐19 by type of organ transplant (p = .122). Twenty‐five of the 27 patients testing positive for COVID‐19 reported symptomatic infection, only nine of whom were hospitalized. No patients were mechanically ventilated and no deaths due to COVID‐19 occurred. No significant changes in graft function were observed. Clinically significant rejection was diagnosed and treated in four patients. COVID‐19 breakthrough infection rates remained low in immunocompromised solid organ transplant recipients who received tix/cil. No significant immunologic risks were observed. 10.1111/ctr.15261 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.15261 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15261 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Tixagevimab/cilgavimab for the prevention of COVID‐19 in solid organ transplant recipients Emily Eribes Cassandra Votruba Tyler Tinkham Angela Huang Dan Ilges Katie Kunze Madeline Hudson Clinical Transplantation Tixagevimab/cilgavimab for the prevention of COVID‐19 in solid organ transplant recipients Emily Eribes Cassandra Votruba Tyler Tinkham Angela Huang Dan Ilges Katie Kunze Madeline Hudson Clinical Transplantation AbstractTixagevimab/cilgavimab (tix/cil) received emergency use authorization in December 2021 for pre‐exposure prophylaxis against COVID‐19 in moderately to severely immunocompromised patients. Our study aimed to describe the incidence of COVID‐19 infection and assess the immunologic risks associated with tix/cil in kidney, pancreas, liver, and heart transplant recipients. Retrospective chart review was completed to provide descriptive analysis. Outcomes data included COVID‐19 infection, severity of COVID‐19 infection, graft function, and rejection. Safety outcomes included cardiovascular (CV) and hypersensitivity events post tix/cil administration. A total of 410 transplant patients were included in the analysis: 20 heart, 92 liver, 243 kidney, 25 simultaneous pancreas/kidney, 23 simultaneous liver/kidney, and seven simultaneous heart/kidney. Twenty‐seven (6.5%) patients tested positive for COVID‐19 via PCR or antigen test post tix/cil. No apparent difference was observed in patients testing positive for COVID‐19 by type of organ transplant (p = .122). Twenty‐five of the 27 patients testing positive for COVID‐19 reported symptomatic infection, only nine of whom were hospitalized. No patients were mechanically ventilated and no deaths due to COVID‐19 occurred. No significant changes in graft function were observed. Clinically significant rejection was diagnosed and treated in four patients. COVID‐19 breakthrough infection rates remained low in immunocompromised solid organ transplant recipients who received tix/cil. No significant immunologic risks were observed. 10.1111/ctr.15261 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Tixagevimab/cilgavimab for the prevention of COVID‐19 in solid organ transplant recipients |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15261 |