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| Autori principali: | , , , , , , , , , , , , , , , , |
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| Natura: | Artículo Open Access |
| Pubblicazione: |
Wiley
2024
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| Soggetti: | |
| Accesso online: | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15297 |
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Sommario:
- Stepwise development and expansion of an abdominal normothermic regional perfusion program for donation after circulatory determination of death organ procurement Anji Wall Priya Arunachalam Eric Martinez Richard Ruiz Hoylan Fernandez Johanna Bayer Amar Gupta Gregory J McKenna Seung‐Hee Lee Bradley Adams Douglas Butler Scott Noesges Michael Duncan Murphy Rayle Kara Monday Gary Schwartz Giuliano Testa Clinical Transplantation AbstractIntroductionNormothermic regional perfusion (NRP) represents an innovative technology that improves the outcomes for liver and kidney recipients of donation after circulatory determination of death (DCD) organs but protocols for abdominal‐only NRP (A‐NRP) DCD are lacking in the US.MethodsWe describe the implementation and expansion strategies of a transplant‐center‐based A‐NRP DCD program that has grown in volume, geographical reach, and donor acceptance parameters, presented as four eras.ResultsIn the implementation era, two donors were attempted, and one liver graft was transplanted. In the local expansion era, 33% of attempted donors resulted in transplantation and 42% of liver grafts from donors who died within the functional warm ischemic time (fWIT) limit were transplanted. In the Regional Expansion era, 25% of attempted donors resulted in transplantation and 50% of liver grafts from donors who died within the fWIT limit were transplanted. In the Donor Acceptance Expansion era, 46% of attempted donors resulted in transplantation and 72% of liver grafts from donors who died within the fWIT limit were transplanted. Eight discarded grafts demonstrated a potential opportunity for utilization.ConclusionThe stepwise approach to building an A‐NRP program described here can serve as a model for other transplant centers. 10.1111/ctr.15297 http://onlinelibrary.wiley.com/termsAndConditions#vor