Mortality and morbidity after combined heart and liver transplantation in the failing Fontan: An updated dual center retrospective study
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| Natura: | Artículo Open Access |
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Wiley
2024
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| author | Sumeet S. Vaikunth Juan M. Ortega‐Legaspi Desiree R. Conrad Sharon Chen Tami Daugherty Christiane L. Haeffele Jeffrey Teuteberg Rhondalynn Mclean John W. MacArthur Y. Joseph Woo Katsuhide Maeda Michael Ma Teimour Nasirov Marrouf Hoteit Moira B. Hilscher Joyce Wald Tal Mandelbaum Kim M. Olthoff Peter L. Abt Pavan Atluri Marisa Cevasco Constantine D. Mavroudis Stephanie Fuller George K. Lui Yuli Y. Kim |
| author_facet | Sumeet S. Vaikunth Juan M. Ortega‐Legaspi Desiree R. Conrad Sharon Chen Tami Daugherty Christiane L. Haeffele Jeffrey Teuteberg Rhondalynn Mclean John W. MacArthur Y. Joseph Woo Katsuhide Maeda Michael Ma Teimour Nasirov Marrouf Hoteit Moira B. Hilscher Joyce Wald Tal Mandelbaum Kim M. Olthoff Peter L. Abt Pavan Atluri Marisa Cevasco Constantine D. Mavroudis Stephanie Fuller George K. Lui Yuli Y. Kim Sumeet S. Vaikunth Juan M. Ortega‐Legaspi Desiree R. Conrad Sharon Chen Tami Daugherty Christiane L. Haeffele Jeffrey Teuteberg Rhondalynn Mclean John W. MacArthur Y. Joseph Woo Katsuhide Maeda Michael Ma Teimour Nasirov Marrouf Hoteit Moira B. Hilscher Joyce Wald Tal Mandelbaum Kim M. Olthoff Peter L. Abt Pavan Atluri Marisa Cevasco Constantine D. Mavroudis Stephanie Fuller George K. Lui Yuli Y. Kim |
| collection | Wiley Open Access |
| contents | Mortality and morbidity after combined heart and liver transplantation in the failing Fontan: An updated dual center retrospective study Sumeet S. Vaikunth Juan M. Ortega‐Legaspi Desiree R. Conrad Sharon Chen Tami Daugherty Christiane L. Haeffele Jeffrey Teuteberg Rhondalynn Mclean John W. MacArthur Y. Joseph Woo Katsuhide Maeda Michael Ma Teimour Nasirov Marrouf Hoteit Moira B. Hilscher Joyce Wald Tal Mandelbaum Kim M. Olthoff Peter L. Abt Pavan Atluri Marisa Cevasco Constantine D. Mavroudis Stephanie Fuller George K. Lui Yuli Y. Kim Clinical Transplantation AbstractIntroductionAs the adult Fontan population with Fontan associated liver disease continues to increase, more patients are being referred for transplantation, including combined heart and liver transplantation.MethodsWe report updated mortality and morbidity outcomes after combined heart and liver transplant in a retrospective cohort series of 40 patients (age 14 to 49 years) with Fontan circulation across two centers from 2006–2022.ResultsThe 30‐day, 1‐year, 5‐year and 10‐year survival rate was 90%, 80%, 73% and 73% respectively. Sixty percent of patients met a composite comorbidity of needing either post‐transplant mechanical circulatory support, renal replacement therapy or tracheostomy. Cardiopulmonary bypass time > 283 min (4.7 h) and meeting the composite comorbidity were associated with mortality by Kaplan Meier analysis.ConclusionFurther study to mitigate early mortality and the above comorbidities as well as the high risk of bleeding and vasoplegia in this patient population is warranted. 10.1111/ctr.15302 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.15302 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15302 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Mortality and morbidity after combined heart and liver transplantation in the failing Fontan: An updated dual center retrospective study Sumeet S. Vaikunth Juan M. Ortega‐Legaspi Desiree R. Conrad Sharon Chen Tami Daugherty Christiane L. Haeffele Jeffrey Teuteberg Rhondalynn Mclean John W. MacArthur Y. Joseph Woo Katsuhide Maeda Michael Ma Teimour Nasirov Marrouf Hoteit Moira B. Hilscher Joyce Wald Tal Mandelbaum Kim M. Olthoff Peter L. Abt Pavan Atluri Marisa Cevasco Constantine D. Mavroudis Stephanie Fuller George K. Lui Yuli Y. Kim Clinical Transplantation Mortality and morbidity after combined heart and liver transplantation in the failing Fontan: An updated dual center retrospective study Sumeet S. Vaikunth Juan M. Ortega‐Legaspi Desiree R. Conrad Sharon Chen Tami Daugherty Christiane L. Haeffele Jeffrey Teuteberg Rhondalynn Mclean John W. MacArthur Y. Joseph Woo Katsuhide Maeda Michael Ma Teimour Nasirov Marrouf Hoteit Moira B. Hilscher Joyce Wald Tal Mandelbaum Kim M. Olthoff Peter L. Abt Pavan Atluri Marisa Cevasco Constantine D. Mavroudis Stephanie Fuller George K. Lui Yuli Y. Kim Clinical Transplantation AbstractIntroductionAs the adult Fontan population with Fontan associated liver disease continues to increase, more patients are being referred for transplantation, including combined heart and liver transplantation.MethodsWe report updated mortality and morbidity outcomes after combined heart and liver transplant in a retrospective cohort series of 40 patients (age 14 to 49 years) with Fontan circulation across two centers from 2006–2022.ResultsThe 30‐day, 1‐year, 5‐year and 10‐year survival rate was 90%, 80%, 73% and 73% respectively. Sixty percent of patients met a composite comorbidity of needing either post‐transplant mechanical circulatory support, renal replacement therapy or tracheostomy. Cardiopulmonary bypass time > 283 min (4.7 h) and meeting the composite comorbidity were associated with mortality by Kaplan Meier analysis.ConclusionFurther study to mitigate early mortality and the above comorbidities as well as the high risk of bleeding and vasoplegia in this patient population is warranted. 10.1111/ctr.15302 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Mortality and morbidity after combined heart and liver transplantation in the failing Fontan: An updated dual center retrospective study |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15302 |