Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review
Fuente:
Wiley Open Access
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2024
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1867015414946463746 |
|---|---|
| author | Christian Tibor Josef Magyar Charlene Pierrine Gretener Patricia Baldi Federico Storni Corina Kim‐Fuchs Daniel Candinas Annalisa Berzigotti Matthias Knecht Guido Beldi Cédric Hirzel Daniel Sidler David Reineke Vanessa Banz |
| author_facet | Christian Tibor Josef Magyar Charlene Pierrine Gretener Patricia Baldi Federico Storni Corina Kim‐Fuchs Daniel Candinas Annalisa Berzigotti Matthias Knecht Guido Beldi Cédric Hirzel Daniel Sidler David Reineke Vanessa Banz Christian Tibor Josef Magyar Charlene Pierrine Gretener Patricia Baldi Federico Storni Corina Kim‐Fuchs Daniel Candinas Annalisa Berzigotti Matthias Knecht Guido Beldi Cédric Hirzel Daniel Sidler David Reineke Vanessa Banz |
| collection | Wiley Open Access |
| contents | Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review Christian Tibor Josef Magyar Charlene Pierrine Gretener Patricia Baldi Federico Storni Corina Kim‐Fuchs Daniel Candinas Annalisa Berzigotti Matthias Knecht Guido Beldi Cédric Hirzel Daniel Sidler David Reineke Vanessa Banz Clinical Transplantation AbstractIntroductionSolid organ transplantation (SOT) is a lifesaving treatment for end‐stage organ failure. Although many factors affect the success of organ transplantation, recipient and donor sex are important biological factors influencing transplant outcome. However, the impact of the four possible recipient and donor sex combinations (RDSC) on transplant outcome remains largely unclear.MethodsA scoping review was carried out focusing on studies examining the association between RDSC and outcomes (mortality, graft rejection, and infection) after heart, lung, liver, and kidney transplantation. All studies up to February 2023 were included.ResultsMultiple studies published between 1998 and 2022 show that RDSC is an important factor affecting the outcome after organ transplantation. Male recipients of SOT have a higher risk of mortality and graft failure than female recipients. Differences regarding the causes of death are observed. Female recipients on the other hand are more susceptible to infections after SOT.ConclusionDifferences in underlying illnesses as well as age, immunosuppressive therapy and underlying biological mechanisms among male and female SOT recipients affect the post‐transplant outcome. However, the precise mechanisms influencing the interaction between RDSC and post‐transplant outcome remain largely unclear. A better understanding of how to identify and modulate these factors may improve outcome, which is particularly important in light of the worldwide organ shortage. An analysis for differences of etiology and causes of graft loss or mortality, respectively, is warranted across the RDSC groups.Practitioner points Recipient and donor sex combinations affect outcome after solid organ transplantation. While female recipients are more susceptible to infections after solid organ transplantation, they have higher overall survival following SOT, with causes of death differing from male recipients. Sex‐differences should be taken into account in the post‐transplant management. 10.1111/ctr.15312 http://creativecommons.org/licenses/by-nc/4.0/ |
| doi_str_mv | 10.1111/ctr.15312 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15312 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review Christian Tibor Josef Magyar Charlene Pierrine Gretener Patricia Baldi Federico Storni Corina Kim‐Fuchs Daniel Candinas Annalisa Berzigotti Matthias Knecht Guido Beldi Cédric Hirzel Daniel Sidler David Reineke Vanessa Banz Clinical Transplantation Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review Christian Tibor Josef Magyar Charlene Pierrine Gretener Patricia Baldi Federico Storni Corina Kim‐Fuchs Daniel Candinas Annalisa Berzigotti Matthias Knecht Guido Beldi Cédric Hirzel Daniel Sidler David Reineke Vanessa Banz Clinical Transplantation AbstractIntroductionSolid organ transplantation (SOT) is a lifesaving treatment for end‐stage organ failure. Although many factors affect the success of organ transplantation, recipient and donor sex are important biological factors influencing transplant outcome. However, the impact of the four possible recipient and donor sex combinations (RDSC) on transplant outcome remains largely unclear.MethodsA scoping review was carried out focusing on studies examining the association between RDSC and outcomes (mortality, graft rejection, and infection) after heart, lung, liver, and kidney transplantation. All studies up to February 2023 were included.ResultsMultiple studies published between 1998 and 2022 show that RDSC is an important factor affecting the outcome after organ transplantation. Male recipients of SOT have a higher risk of mortality and graft failure than female recipients. Differences regarding the causes of death are observed. Female recipients on the other hand are more susceptible to infections after SOT.ConclusionDifferences in underlying illnesses as well as age, immunosuppressive therapy and underlying biological mechanisms among male and female SOT recipients affect the post‐transplant outcome. However, the precise mechanisms influencing the interaction between RDSC and post‐transplant outcome remain largely unclear. A better understanding of how to identify and modulate these factors may improve outcome, which is particularly important in light of the worldwide organ shortage. An analysis for differences of etiology and causes of graft loss or mortality, respectively, is warranted across the RDSC groups.Practitioner points Recipient and donor sex combinations affect outcome after solid organ transplantation. While female recipients are more susceptible to infections after solid organ transplantation, they have higher overall survival following SOT, with causes of death differing from male recipients. Sex‐differences should be taken into account in the post‐transplant management. 10.1111/ctr.15312 http://creativecommons.org/licenses/by-nc/4.0/ |
| title | Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15312 |