Prevalence of iron deficiency and anemia in pediatric heart transplant recipients
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Wiley
2024
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| author | David M. Newland Kathryn L. Spencer Long D. Do Lisa R. Knorr Michelle M. Palmer Erin L. Albers Joshua M. Friedland‐Little Borah J. Hong Mariska S. Kemna Christina Hartje‐Dunn Dominique G. Mark Thomas L. Nemeth Sara Ravi‐Johnson Yuk M. Law |
| author_facet | David M. Newland Kathryn L. Spencer Long D. Do Lisa R. Knorr Michelle M. Palmer Erin L. Albers Joshua M. Friedland‐Little Borah J. Hong Mariska S. Kemna Christina Hartje‐Dunn Dominique G. Mark Thomas L. Nemeth Sara Ravi‐Johnson Yuk M. Law David M. Newland Kathryn L. Spencer Long D. Do Lisa R. Knorr Michelle M. Palmer Erin L. Albers Joshua M. Friedland‐Little Borah J. Hong Mariska S. Kemna Christina Hartje‐Dunn Dominique G. Mark Thomas L. Nemeth Sara Ravi‐Johnson Yuk M. Law |
| collection | Wiley Open Access |
| contents | Prevalence of iron deficiency and anemia in pediatric heart transplant recipients David M. Newland Kathryn L. Spencer Long D. Do Lisa R. Knorr Michelle M. Palmer Erin L. Albers Joshua M. Friedland‐Little Borah J. Hong Mariska S. Kemna Christina Hartje‐Dunn Dominique G. Mark Thomas L. Nemeth Sara Ravi‐Johnson Yuk M. Law Clinical Transplantation AbstractIntroductionThe prevalence of iron deficiency and anemia in the setting of modern‐day maintenance immunosuppression in pediatric heart transplant (HTx) recipients is unclear. The primary aim was to determine the prevalence of iron deficiency (serum ferritin < 30 ng/mL ± transferrin saturation < 20%) and anemia per World Health Organization diagnostic criteria and associated risk factors.MethodsSingle‐center, cross‐sectional analysis of 200 consecutive pediatric HTx recipients (<21 years old) from 2005 to 2021. Data were collected at 1‐year post‐HTx at the time of annual protocol biopsy.ResultsMedian age at transplant was 3 years (IQR .5–12.2). The median ferritin level was 32 ng/mL with 46% having ferritin < 30 ng/mL. Median transferrin saturation (TSAT) was 22% with 47% having TSAT < 20%. Median hemoglobin was 11 g/dL with 54% having anemia. Multivariable analysis revealed lower absolute lymphocyte count, TSAT < 20%, and estimated glomerular filtration rate <75 mL/min/1.73 m2 were independently associated with anemia. Ferritin < 30 ng/mL in isolation was not associated with anemia. Ferritin < 30 ng/mL may aid in detecting absolute iron deficiency while TSAT < 20% may be useful in identifying patients with functional iron deficiency ± anemia in pediatric HTx recipients.ConclusionIron deficiency and anemia are highly prevalent in pediatric HTx recipients. Future studies are needed to assess the impact of iron deficiency, whether with or without anemia, on clinical outcomes in pediatric HTx recipients. 10.1111/ctr.15367 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.15367 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15367 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Prevalence of iron deficiency and anemia in pediatric heart transplant recipients David M. Newland Kathryn L. Spencer Long D. Do Lisa R. Knorr Michelle M. Palmer Erin L. Albers Joshua M. Friedland‐Little Borah J. Hong Mariska S. Kemna Christina Hartje‐Dunn Dominique G. Mark Thomas L. Nemeth Sara Ravi‐Johnson Yuk M. Law Clinical Transplantation Prevalence of iron deficiency and anemia in pediatric heart transplant recipients David M. Newland Kathryn L. Spencer Long D. Do Lisa R. Knorr Michelle M. Palmer Erin L. Albers Joshua M. Friedland‐Little Borah J. Hong Mariska S. Kemna Christina Hartje‐Dunn Dominique G. Mark Thomas L. Nemeth Sara Ravi‐Johnson Yuk M. Law Clinical Transplantation AbstractIntroductionThe prevalence of iron deficiency and anemia in the setting of modern‐day maintenance immunosuppression in pediatric heart transplant (HTx) recipients is unclear. The primary aim was to determine the prevalence of iron deficiency (serum ferritin < 30 ng/mL ± transferrin saturation < 20%) and anemia per World Health Organization diagnostic criteria and associated risk factors.MethodsSingle‐center, cross‐sectional analysis of 200 consecutive pediatric HTx recipients (<21 years old) from 2005 to 2021. Data were collected at 1‐year post‐HTx at the time of annual protocol biopsy.ResultsMedian age at transplant was 3 years (IQR .5–12.2). The median ferritin level was 32 ng/mL with 46% having ferritin < 30 ng/mL. Median transferrin saturation (TSAT) was 22% with 47% having TSAT < 20%. Median hemoglobin was 11 g/dL with 54% having anemia. Multivariable analysis revealed lower absolute lymphocyte count, TSAT < 20%, and estimated glomerular filtration rate <75 mL/min/1.73 m2 were independently associated with anemia. Ferritin < 30 ng/mL in isolation was not associated with anemia. Ferritin < 30 ng/mL may aid in detecting absolute iron deficiency while TSAT < 20% may be useful in identifying patients with functional iron deficiency ± anemia in pediatric HTx recipients.ConclusionIron deficiency and anemia are highly prevalent in pediatric HTx recipients. Future studies are needed to assess the impact of iron deficiency, whether with or without anemia, on clinical outcomes in pediatric HTx recipients. 10.1111/ctr.15367 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Prevalence of iron deficiency and anemia in pediatric heart transplant recipients |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15367 |